Psilocybin, a substance mainly found in mushrooms of the genus psilocybe, has been historically used for ritualistic, recreational and,…
Medicine & Health
Emerging therapies in mental health
In this PLOS ONE curated collection we highlight a range of novel evidence-based approaches to mental health by bringing together diverse perspectives from pharmacology, psychology, psychiatry, and neuroscience to: (1) explore novel pharmacological treatment modalities; (2) investigate methods to interact with the brain invasively and non-invasively; (3) highlight novel technological approaches to the treatment and management of mental illness.
Using methods and tools at the forefront of physiology, pharmacology, cognitive sciences, psychiatry, engineering, and neuroscience, the papers in this collection propose potential solutions to therapeutic challenges often labeled intractable.
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PLOS ONE Collection
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PLOS ONE Self-reported negative outcomes of psilocybin users: A quantitative textual analysis
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PLOS ONE The short-term impact of 3 smoked cannabis preparations versus placebo on PTSD symptoms: A randomized cross-over clinical trial
Importance: There is a pressing need for development of novel pharmacology for the treatment of Posttraumatic Stress Disorder (PTSD). Given…
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PLOS ONE The cost-effectiveness of MDMA-assisted psychotherapy for the treatment of chronic, treatment-resistant PTSD
Background: Chronic posttraumatic stress disorder (PTSD) is a disabling condition that generates considerable morbidity, mortality, and…
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PLOS ONE The female side of pharmacotherapy for ADHD—A systematic literature review
Objective: This comprehensive review examined sex differences in prescription rates and efficacy or effectiveness of pharmacotherapy…
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PLOS ONE Impulsivity in Parkinson’s disease patients treated with subthalamic nucleus deep brain stimulation—An exploratory study
Background: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a recognized treatment in Parkinson’s disease (PD). Knowledge is…
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PLOS ONE Understanding importance of clinical biomarkers for diagnosis of anxiety disorders using machine learning models
Anxiety disorders are a group of mental illnesses that cause constant and overwhelming feelings of anxiety and fear. Excessive anxiety can…
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PLOS ONE A preliminary study of resting brain metabolism in treatment-resistant depression before and after treatment with olanzapine-fluoxetine combination
Treatment-resistant depression (TRD) occurs in many patients and causes high morbidity and mortality. Because TRD subjects are…
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PLOS ONE Feasibility of remotely supervised transcranial direct current stimulation and cognitive remediation: A systematic review
With technological advancements and an aging population, there is growing interest in delivering interventions at home. Transcranial…
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PLOS ONE Oxolipidomics profile in major depressive disorder: Comparing remitters and non-remitters to repetitive transcranial magnetic stimulation treatment
Background: Repetitive Transcranial Magnetic Stimulation [rTMS] is increasingly being used to treat Major Depressive Disorder [MDD]. Given…