The Signaling Pathways Project is a multi-omics knowledgebase based upon public, manually curated transcriptomic and cistromic (ChIP-Seq) datasets involving genetic and small molecule manipulations of…
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Medicine & Health Cardiovascular DiseasesView Collection
Cardiovascular disease (CVD) is the number one cause of death and disability globally, with an estimated 17.7 million deaths from CVD in 2015. More than three-quarters of CVD deaths occur in low- and…
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Medicine & Health Dementia: Across the Lifespan & Around the GlobeView Collection
Alzheimer’s Disease International (ADI) estimates there will be over 131.5 million people living with dementia by 2050, as well as a shift in burden from the richest to poorest…
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Medicine & Health Traumatic InjuryView Collection
Traumatic injury has long been recognized as a neglected disease of extremely high burden. With this Special Issue, PLOS Medicine and guest editors Professor Karim Brohi and Dr Martin Schreiber…
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Medicine & Health Voluntary Medical Male Circumcision for HIV Prevention: Improving Quality, Efficiency, Cost Effectiveness, & Demand for Services during an Accelerated Scale-upView Collection
With new HIV infections in Sub-Saharan Africa occurring at a rate of 2.3 million each year, this new collection presents interim results from a large public health intervention of voluntary medical…
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Medicine & Health Editor’s Picks: Co-Infection in Tropical MedicineView Collection
Co-infection with more than one pathogen is a continuing challenge in global health, particularly in regions with multiple endemic infectious diseases. Direct and indirect interactions between…
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Medicine & Health Burden of Infectious Diseases in EuropeView Collection
The Burden of Communicable Diseases in Europe (BCoDE) aimed to estimate the burden of communicable diseases applying a pathogen and incidence based approach to estimating DALYs (Disability Adjusted…
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Medicine & Health Cardiovascular ScienceView Collection
The complexity of the cardiovascular system has sparked increasing interest in characterizing the interplay between different components of the heart and blood vessels. In this collection of articles…
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Biology & Life Sciences Advances in HIV Mucosal Immunology: Challenges and OpportunitiesView Collection
Without reliable methods to evaluate how the mucosal immune system responds to an experimental HIV vaccine, important information about how well that vaccine worked is missed. The HIV Mucosal…
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Medicine & Health The Prevention, Diagnosis and Treatment of Sexually Transmitted InfectionsView Collection
Globally, the World Health Organization (WHO) estimates that more than one million new sexually transmitted infections (STIs) occur each day, incurring a very substantial burden of morbidity…
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Medicine & Health Minimally invasive autopsy for cause of death determination in high burden settingsView Collection
In most middle and low-income countries, mortality data are crucial information to prioritize health policies but are inferred through highly inaccurate methods. Minimally invasive autopsy, a newly…