Biology & Life Sciences
Modeling Cell Proliferation and the Cell Microenvironment
Cells use elaborate mechanisms to sense a variety of mechanical and biochemical cues in their environment, to integrate this information, and to generate coherent adaptive responses. A more complete understanding of these interactions will provide new opportunities for tissue and biomaterials engineering, as well as immunology and cancer research.
This collection compiles a range of research that improves the field by building on existing methods and algorithms to better model phenomena such as fibrotic remodeling, cancer metastasis, wound healing and development and much more.
Image Credit: Ricardo Murga and Rodney Donlan, Public domain, via Wikimedia Commons
From the Blog
Guest Editors
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Guest Editor, PLOS ONE Aurélie Carlier
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Guest Editor, PLOS ONE Ravi Iyengar
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Guest Editor, PLOS ONE Vivek Shenoy
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Guest Editor, PLOS ONE Padmini Rangamani
PLOS ONE Collection
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PLOS ONE A mathematical modelling framework for the regulation of intra-cellular OCT4 in human pluripotent stem cells
Human pluripotent stem cells (hPSCs) have the potential to differentiate into all cell types, a property known as pluripotency. A deeper…
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PLOS ONE An experimental-mathematical approach to predict tumor cell growth as a function of glucose availability in breast cancer cell lines
We present the development and validation of a mathematical model that predicts how glucose dynamics influence metabolism and therefore…
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PLOS ONE Mechanics of biofilms formed of bacteria with fimbriae appendages
Gram-negative bacteria, as well as some Gram-positive bacteria, possess hair-like appendages known as fimbriae, which play an important…
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PLOS ONE Targeting oncogenic mutations in colorectal cancer using cryptotanshinone
Colorectal cancer (CRC) is one of the most prevalent types of cancer in the world and ranks second in cancer deaths in the US. Despite the…
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PLOS ONE A new 3D finite element-based approach for computing cell surface tractions assuming nonlinear conditions
Advances in methods for determining the forces exerted by cells while they migrate are essential for attempting to understand important…
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PLOS ONE High blood flow shear stress values are associated with circulating tumor cells cluster disaggregation in a multi-channel microfluidic device
Metastasis represents a dynamic succession of events involving tumor cells which disseminate through the organism via the bloodstream.…
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PLOS ONE On the influence of cell shape on dynamic reaction-diffusion polarization patterns
The distribution of signaling molecules following mechanical or chemical stimulation of a cell defines cell polarization, with regions of…