Purpose: To evaluate the diagnostic value of symptoms used by daycares and schools to screen children and adolescents for SARS-CoV-2…
COVID-19 pandemic (2019-21)
This Collection of articles highlights all content published across the PLOS journals relating to the COVID-19 pandemic in 2019-21.
PLOS is committed to disseminating research as quickly as possible, particularly in public health emergencies.
All articles published in any PLOS journal are Open Access free of charge to all readers.
Image Credit: US NIH/Public domain (CC-0) and Senado Federal/Flickr (CC-BY)
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PLOS ONE Diagnostic value of symptoms for pediatric SARS-CoV-2 infection in a primary care setting
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Image creditSARS-CoV-2 text with marker by Jernej Furman, CC BY 2.0PLOS ONE Evaluation of SARS-CoV-2 in semen, seminal plasma, and spermatozoa pellet of COVID-19 patients in the acute stage of infection
To date, there is limited information about the presence of SARS-CoV-2 in semen especially in the acute phase of the infection. While…
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PLOS ONE ECG pathology and its association with death in critically ill COVID-19 patients, a cohort study
Background: We investigated the prevalence of ECG abnormalities and their association with mortality, organ dysfunction and cardiac…
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Image creditCovid19 radio by Mike Finn, CC BY 2.0PLOS ONE Understanding the social drivers of antibiotic use during COVID-19 in Bangladesh: Implications for reduction of antimicrobial resistance
Antimicrobial resistance (AMR) is a global public health crisis that is now impacted by the COVID-19 pandemic. Little is known how…
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PLOS ONE Association of ABO blood group with COVID-19 severity, acute phase reactants and mortality
Introduction: Coronavirus disease 2019 (COVID-19) is the ongoing pandemic with multitude of manifestations and association of ABO blood…
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Image creditShroff Eye Hospital by RubyGoes, CC BY 2.0PLOS ONE National Early Warning Score 2 (NEWS2) to predict poor outcome in hospitalised COVID-19 patients in India
Background: While several parameters have emerged as predictors of prognosis of COVID-19, a simple clinical score at baseline might help…
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Image creditHand drawing a chart with COVID-19 text by Jernej Furman, CC BY 2.0PLOS ONE ‘It felt like a black hole, great uncertainty, but we have to take care for our patients’–Qualitative findings on the effects of the COVID-19 pandemic on specialist palliative home care
Background: The COVID-19 pandemic has affected health care systems worldwide. Multidisciplinary teams provide specialist palliative home…
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Image creditCovid-19 word cloud by EpicTop10.com, CC BY 2.0PLOS ONE Clinical features of 375 COVID-19 cases imported from Russia through the Suifenhe port and countermeasures
Background and objectives: At present, the focus of the fighting against COVID-19 in China is shifting to strictly prevent the entrance of…
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PLOS ONE Impact of the early COVID-19 pandemic on outcomes in a rural Ugandan neonatal unit: A retrospective cohort study
Background: During the early COVID-19 pandemic travel in Uganda was tightly restricted which affected demand for and access to care for…
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PLOS Computational Biology Modeling the onset of symptoms of COVID-19: Effects of SARS-CoV-2 variant
Identifying order of symptom onset of infectious diseases might aid in differentiating symptomatic infections earlier in a population…
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PLOS ONE Potential SARS-CoV-2 infectiousness among asymptomatic healthcare workers
A majority of SARS-CoV-2 infections are transmitted from a minority of infected subjects, some of which may be symptomatic or…
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PLOS ONE Factors of parental COVID-19 vaccine hesitancy: A cross sectional study in Japan
The eligibility of COVID-19 vaccines has been expanded to children aged 12 and above in several countries including Japan, and there is a…
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PLOS Medicine Vaccine effectiveness against SARS-CoV-2 infection, hospitalization, and death when combining a first dose ChAdOx1 vaccine with a subsequent mRNA vaccine in Denmark: A nationwide population-based cohort study
Background: The recommendations in several countries to stop using the ChAdOx1 vaccine has led to vaccine programs combining different…
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PLOS ONE Innovations, contestations and fragilities of the health system response to COVID-19 in the Gauteng Province of South Africa
Background: Gauteng province, with 26.3% of South Africa’s population, is the commercial and industrial powerhouse of the country. During…
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PLOS ONE Modelling RT-qPCR cycle-threshold using digital PCR data for implementing SARS-CoV-2 viral load studies
Objectives: To exploit the features of digital PCR for implementing SARS-CoV-2 observational studies by reliably including the viral load…
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PLOS Pathogens The pigtail macaque (Macaca nemestrina) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease
The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 disease, has killed over five million people worldwide as of December…
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PLOS Pathogens SARS-CoV-2 receptor binding domain fusion protein efficiently neutralizes virus infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Currently, as dangerous mutations…
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PLOS Neglected Tropical Diseases The impact of COVID-19 on clinical research for Neglected Tropical Diseases (NTDs): A case study of bubonic plague
Background: Among the many collaterals of the COVID-19 pandemic is the disruption of health services and vital clinical research. COVID-19…
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PLOS ONE Eculizumab in patients with severe coronavirus disease 2019 (COVID-19) requiring continuous positive airway pressure ventilator support: Retrospective cohort study
Background: Complement activation contributes to lung dysfunction in coronavirus disease 2019 (COVID-19). We assessed whether C5 blockade…
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PLOS Biology Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of IFN-mediated innate immune defenses
The pandemic spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent of Coronavirus Disease 2019…
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PLOS Computational Biology SWIFT: A deep learning approach to prediction of hypoxemic events in critically-Ill patients using SpO2 waveform prediction
Hypoxemia is a significant driver of mortality and poor clinical outcomes in conditions such as brain injury and cardiac arrest in…
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PLOS ONE Adverse events following the first dose of Covishield (ChAdOx1 nCoV-19) vaccination among health workers in selected districts of central and western Nepal: A cross-sectional study
Introduction: The study aimed at exploring the adverse events following immunization (AEFI) and their incidences among health workers in…
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PLOS ONE Tracheostomy in COVID-19 acute respiratory distress syndrome patients and follow-up: A parisian bicentric retrospective cohort
Background: Tracheostomy has been proposed as an option to help organize the healthcare system to face the unprecedented number of patients…
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PLOS ONE Awareness and preparedness of healthcare workers against the first wave of the COVID-19 pandemic: A cross-sectional survey across 57 countries
Background: Since the COVID-19 pandemic began, there have been concerns related to the preparedness of healthcare workers (HCWs). This…
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PLOS ONE Mortality predictors of hospitalized patients with COVID-19: Retrospective cohort study from Nur-Sultan, Kazakhstan
Background: First reported case of Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) in Kazakhstan was identified in…
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PLOS ONE Clinical evaluation of the SD Biosensor SARS-CoV-2 saliva antigen rapid test with symptomatic and asymptomatic, non-hospitalized patients
Background: Performance of the SD Biosensor saliva antigen rapid test was evaluated at a large designated testing site in non-hospitalized…
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PLOS ONE Seroprevalence of antibodies against SARS-Cov-2 in the high impacted sub-district in Jakarta, Indonesia
Background: Understanding the actual prevalence of COVID-19 transmission in the community is vital for strategic responses to the pandemic.…
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PLOS ONE Epidemiological characteristics of COVID-19 travel-associated cases in Vojvodina, Serbia, during 2020
Coronavirus disease 2019 (COVID-19) is currently the biggest public health problem worldwide. Intensive international travel and tourism…
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PLOS ONE Low incidence of COVID-19 in a prospective cohort of patients with liver cirrhosis and hepatocellular carcinoma treated at a tertiary medical center during the 2020 pandemic
Background and aims: Patients with liver cirrhosis (LC) are considered to be at increased risk for mortality when acquiring SARS-CoV-2…
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PLOS ONE Diagnosis of tuberculosis among COVID-19 suspected cases in Ghana
Background: Tuberculosis (TB) and COVID-19 pandemics are both diseases of public health threat globally. Both diseases are caused by…
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PLOS ONE Colchicine use in patients with COVID-19: A systematic review and meta-analysis
Introduction: Colchicine may inhibit inflammasome signaling and reduce proinflammatory cytokines, a purported mechanism of COVID-19…
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PLOS ONE Real-world treatment patterns and clinical outcomes for inpatients with COVID-19 in the US from September 2020 to February 2021
The objective of this retrospective cohort study was to describe pre-treatment characteristics, treatment patterns, health resource use,…
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Image credit161013 Hospitalisation by Randalfino, CC BY 2.0PLOS ONE Determinants of severity among hospitalised COVID-19 patients: Hospital-based case-control study, India, 2020
Background: Risk factors for the development of severe COVID-19 disease and death have been widely reported across several studies.…
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Image creditPhaplu Hospital, Nepal by Peter Dalsgaard, CC BY 2.0PLOS ONE Experiences of COVID-19 patients admitted in a government infectious disease hospital in Nepal and its implications for health system strengthening: A qualitative study
Introduction: The COVID-19 pandemic has affected the health systems in many ways. It has put unprecedented strain on health systems…
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Image creditHospital Bed by Jeff Adair, CC BY 2.0PLOS ONE COVID-19 associated hospitalization in 571 patients with fibromyalgia—A population-based study
Objective: To identify predicators of patients with fibromyalgia (FM) that are associated with a severe COVID-19 disease course. Methods:…
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PLOS ONE COVID-positive ankle fracture patients are at increased odds of perioperative surgical complications following open reduction internal fixation surgery
Introduction: Ankle fractures have continued to occur through the COVID pandemic and, regardless of patient COVID status, often need…
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PLOS ONE Incidence of COVID-19 reinfection among Midwestern healthcare employees
Given the overwhelming worldwide rate of infection and the disappointing pace of vaccination, addressing reinfection is critical.…
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PLOS Neglected Tropical Diseases Disease characteristics and serological responses in patients with differing severity of COVID-19 infection: A longitudinal cohort study in Dhaka, Bangladesh
Background: COVID-19 caused by SARS-CoV-2 ranges from asymptomatic to severe disease and can cause fatal and devastating outcome in many…
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PLOS ONE Analytical performances of the AMPLIQUICK® Respiratory Triplex assay for simultaneous detection and differentiation of SARS-CoV-2, influenza A/B and respiratory syncytial viruses in respiratory specimens
Although patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A, influenza B and respiratory…
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PLOS ONE Clotting events among hospitalized patients infected with COVID-19 in a large multisite cohort in the United States
Introduction: COVID-19 infection has been hypothesized to precipitate venous and arterial clotting events more frequently than other…
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PLOS ONE Baseline clinical features of COVID-19 patients, delay of hospital admission and clinical outcome: A complex relationship
Introduction: Delay between symptom onset and access to care is essential to prevent clinical worsening for different infectious diseases.…
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PLOS ONE Angiotensin II receptor blocker intake associates with reduced markers of inflammatory activation and decreased mortality in patients with cardiovascular comorbidities and COVID-19 disease
Aims: Patients with cardiovascular comorbidities have a significantly increased risk for a critical course of COVID-19. As the SARS-CoV2…
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PLOS ONE Evaluation of clinical outcomes of patients with mild symptoms of coronavirus disease 2019 (COVID-19) discharged from the emergency department
Introduction: This study was performed to determine the clinical outcomes of patients with mild symptoms of COVID-19 discharged from the…
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PLOS ONE Clinical characteristics and viral load dynamics of COVID-19 in a mildly or moderately symptomatic outpatient sample
Background: Studies of outpatients with mild or moderate COVID-19 are uncommon. We studied: 1) association of symptoms with reverse…
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PLOS ONE SARS-CoV-2 infection and cardiovascular or pulmonary complications in ambulatory care: A risk assessment based on routine data
Background: Risk factors of severe COVID-19 have mainly been investigated in the hospital setting. We investigated pre-defined risk factors…
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PLOS ONE Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis
Objective: The proportion of COVID-19 patients having active pulmonary tuberculosis, and its impact on COVID-19 related patient outcomes,…
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PLOS ONE Mortality in association with antipsychotic medication use and clinical outcomes among geriatric psychiatry outpatients with COVID-19
Objectives: Older adults are particularly vulnerable to the negative consequences of antipsychotic exposure and are disproportionally…
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PLOS ONE High association of COVID-19 severity with poor gut health score in Lebanese patients
Background: Coronavirus disease 2019 (COVID-19) has affected millions of lives globally. However, the disease has presented more extreme…
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PLOS ONE Characteristics and outcome of critically ill patients with coronavirus disease-2019 (COVID-19) pneumonia admitted to a tertiary care center in the United Arab Emirates during the first wave of the SARS-CoV-2 pandemic. A retrospective analysis
Background: The aim of this study was to describe the clinical characteristics and outcome of patients with coronavirus disease-2019…
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PLOS Pathogens Induction of trained immunity by influenza vaccination – impact on COVID-19
Non-specific protective effects of certain vaccines have been reported, and long-term boosting of innate immunity, termed trained…
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PLOS ONE Early administration of remdesivir to COVID-19 patients associates with higher recovery rate and lower need for ICU admission: A retrospective cohort study
Objectives: Remdesivir is one of the most widely recommended and used medications for COVID-19 treatment. However, different outcomes have…
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PLOS ONE Clinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohort
The objective was to describe the clinical characteristics and outcomes of hospitalized COVID-19 patients during the two different…
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PLOS ONE Disulfiram use is associated with lower risk of COVID-19: A retrospective cohort study
Effective, low-cost therapeutics are needed to prevent and treat COVID-19. Severe COVID-19 disease is linked to excessive inflammation.…
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PLOS ONE Impact of persistent D-dimer elevation following recovery from COVID-19
Background: Elevated D-dimer is known as predictor for severity of SARS-CoV2-infection. Increased D-dimer is associated with thromboembolic…
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PLOS ONE Heart-rate-variability (HRV), predicts outcomes in COVID-19
Background: Patients with COVID-19 present with a variety of clinical manifestations, ranging from mild or asymptomatic disease to severe…
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PLOS ONE Impact of Covid-19 on health-related quality of life of patients: A structured review
Introduction: Coronavirus disease (Covid-19) has led to a global pandemic since its emergence in December 2019. The majority of research…
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PLOS ONE Self-medication practices to prevent or manage COVID-19: A systematic review
Background: Previous studies have assessed the prevalence and characteristics of self-medication in COVID-19. However, no systematic review…
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PLOS ONE Neoadjuvant chemotherapy with dose dense MVAC is associated with improved survival after radical cystectomy compared to other cytotoxic regimens: A tertiary center experience
Introduction: Neoadjuvant chemotherapy has become standard of care for cisplatin-eligible patients with muscle-invasive bladder cancer…
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PLOS ONE Effect of famotidine on hospitalized patients with COVID-19: A systematic review and meta-analysis
Introduction: Famotidine is a competitive histamine H2-receptor antagonist most commonly used for gastric acid suppression but thought to…
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PLOS ONE Mortality and evolution between community and hospital-acquired COVID-AKI
Background: Acute kidney injury (AKI) is associated with poor outcomes in COVID patients. Differences between hospital-acquired (HA-AKI)…
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PLOS ONE Is the BNT162b2 COVID-19 vaccine effective in elderly populations? Results from population data from Bavaria, Germany
Background: The efficacy of the BioNTech-Pfizer BNT162b2 vaccination in the elderly (≥80 years) could not be fully assessed in the…
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PLOS ONE Factors influencing nurses’ behavioral intention toward caring for COVID-19 patients on mechanical ventilation: A cross-sectional study
Objectives: To investigate nurses’ behavioral intention toward caring for COVID-19 patients on mechanical ventilation, as well as the…
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PLOS ONE Regular testing of asymptomatic healthcare workers identifies cost-efficient SARS-CoV-2 preventive measures
Protecting healthcare professionals is crucial in maintaining a functioning healthcare system. The risk of infection and optimal…
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PLOS ONE Transmission dynamics, clinical characteristics and sero-surveillance in the COVID-19 outbreak in a population dense area of Colombo, Sri Lanka April- May 2020
Background: The transmission dynamics of SARS-CoV-2 varies depending on social distancing measures, circulating SARS-CoV-2 variants, host…
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PLOS ONE Humoral responses to SARS-CoV-2 mRNA vaccines: Role of past infection
Two mRNA vaccines (BNT162b2 and mRNA-1273) against severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) are globally authorized as…
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PLOS ONE Olfactory recovery following infection with COVID-19: A systematic review
Olfactory loss has been identified as one of the common symptoms related to COVID-19 infection. Although olfactory loss is recognized, our…
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PLOS ONE A mixed-methods systematic review of post-viral fatigue interventions: Are there lessons for long Covid?
Objectives: Fatigue syndromes have been widely observed following post-viral infection and are being recognised because of Covid19.…
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PLOS ONE Characteristics and outcome profile of hospitalized African patients with COVID-19: The Ethiopian context
Background: The COVID-19 pandemic seems to have a different picture in Africa; the first case was identified in the continent after it had…
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PLOS ONE Exploring the awareness, attitudes, and actions (AAA) of UK adults at high risk of severe illness from COVID-19
Background: People at high risk of severe illness from COVID-19 have experienced greater restrictions during the pandemic, yet there is a…
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PLOS ONE Evaluation of the SARS-CoV-2 positivity ratio and upper respiratory tract viral load among asymptomatic individuals screened before hospitalization or surgery in Flanders, Belgium
Introduction: The incidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections in the Belgian community is mainly…
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PLOS ONE Atypical lymphocytes in the peripheral blood of COVID-19 patients: A prognostic factor for the clinical course of COVID-19
Background: Clinical observations have shown that there is a relationship between coronavirus disease 2019 (COVID-19) and atypical…
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PLOS ONE Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study
Background: Clinical outcomes among COVID-19 patients vary greatly with age and underlying comorbidities. We aimed to determine the…
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Image credittake your victories where you can by susan myrland, CC BY 2.0PLOS ONE A qualitative assessment of factors affecting nursing home caregiving staff experiences during the COVID-19 pandemic
Background: A large portion of COVID-19 cases and deaths in the United States have occurred in nursing homes; however, current literature…
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PLOS ONE COVID-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women
Objective: To compare hospitalized reproductive age women with COVID-19 who were pregnant, puerperal, or neither one nor the other in terms…
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PLOS Neglected Tropical Diseases COVID-19–associated mucormycosis: Evidence-based critical review of an emerging infection burden during the pandemic’s second wave in India
Coronavirus Disease 2019 (COVID-19), during the second wave in early 2021, has caused devastating chaos in India. As daily infection rates…
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PLOS ONE The clinical course of hospitalized moderately ill COVID-19 patients is mirrored by routine hematologic tests and influenced by renal transplantation
Several studies of patients with COVID-19 have evaluated biological markers for predicting outcomes, most of them retrospectively and with…
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PLOS ONE COVID-19 preventive practices during intrapartum care- adherence and barriers in Ethiopia; a multicenter cross- sectional study
Background: Coronavirus disease 19 (COVID-19) is a newly emerging pandemic affecting more than 120 million people globally. Compliance with…
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PLOS ONE Immunosuppression and COVID-19 infection in British Columbia: Protocol for a linkage study of population-based administrative and self-reported survey data
Introduction: Cases of the novel coronavirus disease (COVID-19) continue to spread around the world even one year after the declaration of…
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PLOS ONE Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia
Introduction: Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide, and several sociodemographic variables,…
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PLOS ONE The burden of SARS-CoV-2 among healthcare workers across 16 hospitals of Kashmir, India—A seroepidemiological study
SARS-CoV-2 pandemic has greatly affected healthcare workers because of the high risk of getting infected. The present cross-sectional…
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PLOS ONE Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture
Last year observed a global pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome-coronavirus 2) infection affecting millions…
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PLOS ONE Physical restraint of dementia patients in acute care hospitals during the COVID-19 pandemic: A cohort analysis in Japan
Introduction: The coronavirus disease (COVID-19) pandemic has caused unprecedented challenges for the medical staff worldwide, especially…
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PLOS ONE Drivers and social implications of Artificial Intelligence adoption in healthcare during the COVID-19 pandemic
The COVID-19 pandemic continues to impact people worldwide–steadily depleting scarce resources in healthcare. Medical Artificial…
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PLOS ONE Changes to telehealth practices in primary care in New Brunswick (Canada): A comparative study pre and during the COVID-19 pandemic
Background: During the COVID-19 pandemic, telehealth technologies were used in the primary health care setting in New Brunswick as a means…
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Image creditBlood pressure monitoring by rawpixel.com, CC 0PLOS ONE Knowledge of and preparedness for COVID-19 among Somali healthcare professionals: A cross-sectional study
Background: Somalia is considered severely underprepared to contain an outbreak of COVID-19, with critical shortages in healthcare…
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PLOS ONE COVID-19 pandemic and health worker stress: The mediating effect of emotional regulation
Background/Introduction: Psychological and physical well-being of health personnel has been significantly affected by COVID-19. Work…
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Image creditCOVID-19 testing training by SC National Guard, CC BY 2.0
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PLOS ONE Association between voriconazole exposure and Sequential Organ Failure Assessment (SOFA) score in critically ill patients
Therapeutic drug monitoring (TDM) is essential for voriconazole to ensure optimal drug exposure, mainly in critically ill patients for…
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Image credit2017_04_29_AMISOM constructs sanitation facility for community near AMISOM base-6 by AMISOM Public Information, CC 0PLOS ONE Factors affecting duration of SARS-Cov-2 viral shedding in mildly symptomatic patients isolated in a community facility
Introduction: Mildly symptomatic cases of Covid-19 in previously-well individuals form the majority of infections and also serve as potent…
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PLOS ONE Drug repurposing for COVID-19 based on an integrative meta-analysis of SARS-CoV-2 induced gene signature in human airway epithelium
Drug repurposing has the potential to bring existing de-risked drugs for effective intervention in an ongoing pandemic—COVID-19 that has…
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PLOS Medicine Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19
Background: Long-COVID refers to a variety of symptoms affecting different organs reported by people following Coronavirus Disease 2019…
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Image credit6VSB spike protein SARS-CoV-2 homotrimer by 5-HT2AR, CC BY 0PLOS ONE Risk for SARS-CoV-2 infection in healthcare workers outside hospitals: A real-life immuno-virological study during the first wave of the COVID-19 epidemic
Objectives: Most COVID-19 related infections and deaths may occur in healthcare outside hospitals. Here we explored SARS-CoV-2 infections…
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PLOS ONE Hydroxychloroquine for the treatment of severe respiratory infection by COVID-19: A randomized controlled trial
Introduction: The novel coronavirus pandemic (COVID–19) represents a major public health problem and it is key to find a treatment that…
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PLOS ONE Risk factors, predictions, and progression of acute kidney injury in hospitalized COVID-19 patients: An observational retrospective cohort study
Objectives: Studies have shown that acute kidney injury (AKI) occurrence post SARS-CoV-2 infection is complex and has a poor prognosis.…
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PLOS ONE A scoping review of patient engagement activities during COVID-19: More consultation, less partnership
Background: The COVID-19 pandemic has had a devastating impact on healthcare systems and care delivery, changing the context for patient…
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PLOS ONE Telehealth at scale can improve chronic disease management in the community during a pandemic: An experience at the time of COVID-19
Background: During the COVID-19 pandemic, telehealth became a vital resource to contain the virus’s spread and ensure continuity of care of…
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PLOS ONE Lower blood pH as a strong prognostic factor for fatal outcomes in critically ill COVID-19 patients at an intensive care unit: A multivariable analysis
Background: Data of critically ill COVID-19 patients are being evaluated worldwide, not only to understand the various aspects of the…
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PLOS ONE Geographical variation in demand, utilization, and outcomes of hospital services for COVID-19 in Brazil: A descriptive serial cross-sectional study
Objective: To analyze the geographical variation in the provision of health services, namely in demand, patterns of utilization, and…
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PLOS ONE Prevalence and risk factors for SARS-CoV-2 infection and seroprevalence among clinical and non-clinical staff in a national healthcare system
Background: While many studies have reported the rate and risk of SARS-CoV-2 infection among healthcare workers (HCWs), there are scant…
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PLOS ONE Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is not detected in the vagina: A prospective study
Objective: To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is present in the vagina of women diagnosed…
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PLOS ONE Aerosol SARS-CoV-2 in hospitals and long-term care homes during the COVID-19 pandemic
Background: Few studies have quantified aerosol concentrations of SARS-CoV-2 in hospitals and long-term care homes, and fewer still have…
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PLOS ONE Implementation of vascular surgery teleconsultation during the COVID-19 pandemic: Insights from the outpatient vascular clinics in a tertiary care hospital in Qatar
Background: The COVID-19 pandemic has sparked a surge in the use of virtual communication tools for delivering clinical services for many…
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PLOS ONE The impact of COVID-19 pandemic on AMI and stroke mortality in Lombardy: Evidence from the epicenter of the pandemic
Background: The first Covid-19 epidemic outbreak has enormously impacted the delivery of clinical healthcare and hospital management…
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PLOS ONE Effect of a hospital-wide campaign on COVID-19 vaccination uptake among healthcare workers in the context of raised concerns for life-threatening side effects
Background: All healthcare workers (HCWs) in Yongin Severance Hospital were allocated to receive the ChAdOx1 nCov-19 vaccine according to…
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PLOS ONE COVID-19-related outcomes in immunocompromised patients: A nationwide study in Korea
Background: Given the rapid increased in confirmed coronavirus disease 2019 (COVID-19) and related mortality, it is important to identify…
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Image creditHepatitis B and hand hold syringe by Marco Verch, CC BY 2.0PLOS ONE Association between chronic hepatitis B infection and COVID-19 outcomes: A Korean nationwide cohort study
Background/Aims: We measured the association between underlying chronic hepatitis B (CHB) and antiviral use with infection rates among…
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PLOS ONE Altered mental status is a predictor of poor outcomes in COVID-19 patients: A cohort study
Introduction: Several studies have described typical clinical manifestations, including fever, cough, diarrhea, and fatigue with COVID-19…
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Image creditHealthcare worker donning the final article of personal protective equipment (PPE), a plastic apron, which would complete his protective uniform by Centers for Disease Control and Prevention, CC 0PLOS ONE Assessment of knowledge, attitude and practice toward COVID-19 and associated factors among health care workers in Silte Zone, Southern Ethiopia
Introduction: COVID-19 is a pandemic respiratory disease caused by the highly contagious novel coronavirus (SARS-CoV 2). The disease is now…
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Image creditSymptoms of coronavirus disease 2019 (cropped) by Mikael Häggström, M.D., CC 0PLOS ONE Severe COVID-19 in inflammatory bowel disease patients in a population-based setting
Objective: Data on the course of severe COVID-19 in inflammatory bowel disease (IBD) patients remains limited. We aimed to determine the…
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PLOS ONE COVID-19 in lung transplant recipients—Risk prediction and outcomes
Patients after lung transplantation are at risk for life-threatening infections. Recently, several publications on COVID-19 outcomes in…
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PLOS ONE Comprehensive evaluation of COVID-19 patient short- and long-term outcomes: Disparities in healthcare utilization and post-hospitalization outcomes
Background: Understanding risk factors for short- and long-term COVID-19 outcomes have implications for current guidelines and practice. We…
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PLOS ONE Disease progression of 213 patients hospitalized with Covid-19 in the Czech Republic in March–October 2020: An exploratory analysis
We collected a multi-centric retrospective dataset of patients (N = 213) who were admitted to ten hospitals in Czech Republic and tested…
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PLOS ONE Reduced turnaround times through multi-sectoral community collaboration during the first surge of SARS-CoV-2 and associated effect on patient care and hospital operations
Background: In March 2020, an influx of admissions in COVID-19 positive patients threatened to overwhelm healthcare facilities in East…
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PLOS ONE Clinical characteristics and outcomes of hospitalized patients with SARS-CoV-2 infection in a Latin American country: Results from the ECCOVID multicenter prospective study
Background: Clinical features and outcomes of SARS-CoV-2 infections diverge in different countries. The aim of this study was to describe…
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PLOS ONE Disparities in telemedicine utilization among surgical patients during COVID-19
Background: Telemedicine has been rapidly adopted in the wake of the COVID-19 pandemic. There is limited work surrounding demographic and…
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PLOS ONE Impacts of mild COVID-19 on elevated use of primary and specialist health care services: A nationwide register study from Norway
Aim: To explore the temporal impact of mild COVID-19 on need for primary and specialist health care services. Methods: In all adults (≥20…
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PLOS ONE Prevalence of SARS-CoV-2 antibodies in the Palestinian population: A primary health center-based cross-sectional study
This study aimed to assess the prevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) total antibodies in the north,…
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PLOS ONE Comprehensive infection control measures prevent hospital-acquired severe acute respiratory syndrome coronavirus 2 infection: A single-center prospective cohort study and seroprevalence survey
Background: Coronavirus disease (COVID-19) is associated with a high mortality rate in older adults; therefore, it is important for medical…
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PLOS ONE Increased risk of hospitalisation and intensive care admission associated with reported cases of SARS-CoV-2 variants B.1.1.7 and B.1.351 in Norway, December 2020 –May 2021
Introduction: Since their emergence, SARS-CoV-2 variants of concern (VOC) B.1.1.7 and B.1.351 have spread worldwide. We estimated the risk…
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PLOS Medicine Transmission of community- and hospital-acquired SARS-CoV-2 in hospital settings in the UK: A cohort study
Background: Nosocomial spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been widely reported, but the…
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Image creditChicago Lakeshore View Aerial by Carol M Highsmith, CC 0PLOS ONE COVID-19 health inequities and association with mechanical ventilation and prolonged length of stay at an urban safety-net health system in Chicago
Millions of Americans have been infected with COVID-19 and communities of color have been disproportionately burdened. We investigated the…
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PLOS ONE Patient attendance at a pediatric emergency referral hospital in an area with low COVID-19 incidence
The purpose of this study was to clarify the effects of individual infection control measures and physical distancing on pediatric medical…
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PLOS ONE J-waves in acute COVID-19: A novel disease characteristic and predictor of mortality?
Background: J-waves represent a common finding in routine ECGs (5–6%) and are closely linked to ventricular tachycardias. While arrhythmias…
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PLOS ONE Clinical and epidemiological characteristics of patients seeking COVID-19 testing in a private centre in Malaysia: Is there a role for private healthcare in battling the outbreak?
Objective: This cross-sectional observational study summarized the baseline characteristics of subjects who underwent COVID-19 molecular…
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PLOS Medicine HMG-CoA reductase inhibitors and COVID-19 mortality in Stockholm, Sweden: A registry-based cohort study
Background: The relationship between statin treatment and Coronavirus Disease 2019 (COVID-19) mortality has been discussed due to the…
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PLOS ONE Association of abnormal pulmonary vasculature on CT scan for COVID-19 infection with decreased diffusion capacity in follow up: A retrospective cohort study
Background: Coronavirus Disease 2019 (COVID-19) is a respiratory viral illness causing pneumonia and systemic disease. Abnormalities in…
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Image credit6VSB spike protein SARS-CoV-2 monomer by 5-HT2AR, CC 0PLOS ONE Risk factors for breakthrough SARS-CoV-2 infection in vaccinated healthcare workers
Background and objective: The risk factors for breakthrough infections among healthcare workers (HCW) after completion of a full course of…
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PLOS ONE Feasibility of CPAP application and variables related to worsening of respiratory failure in pregnant women with SARS-CoV-2 pneumonia: Experience of a tertiary care centre
Continuous positive airway pressure (CPAP) has been successfully applied to patients with COVID-19 to prevent endotracheal intubation.…
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PLOS ONE Understanding an evolving pandemic: An analysis of the clinical time delay distributions of COVID-19 in the United Kingdom
Understanding and monitoring the epidemiological time delay dynamics of SARS-CoV-2 infection provides insights that are key to discerning…
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PLOS ONE Altered smell and taste: Anosmia, parosmia and the impact of long Covid-19
Background: Qualitative olfactory (smell) dysfunctions are a common side effect of post-viral illness and known to impact quality of life…
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PLOS ONE Predictors of severity and development of critical illness of Egyptian COVID-19 patients: A multicenter study
Objectives: We conducted the present multicenter, retrospective study to assess the epidemiological, clinical, laboratory, and radiological…
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PLOS ONE Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence: Navigating the absence of a gold standard
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence studies bridge the gap left from case detection, to…
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PLOS ONE SARS-CoV-2 pneumonia follow-up and long COVID in primary care: A retrospective observational study in Madrid city
Background: Patients with COVID-19 are follow-up in primary care and long COVID is scarcely defined. The study aim was to describe…
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PLOS ONE Use of medicinal plants for COVID-19 prevention and respiratory symptom treatment during the pandemic in Cusco, Peru: A cross-sectional survey
Background: The burden of the COVID-19 pandemic in Peru has led to people seeking alternative treatments as preventives and treatment…
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PLOS ONE A national survey of hospital readiness during the COVID-19 pandemic in Nigeria
Introduction: The COVID-19 pandemic continues to overwhelm health systems across the globe. We aimed to assess the readiness of hospitals…
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PLOS ONE Immunological assessment of SARS-CoV-2 infection in pregnancy from diagnosis to delivery: A multicentre prospective study
Background: Background Population-based data on SARS-CoV-2 infection in pregnancy and assessment of passive immunity to the neonate, is…
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Image creditFig 1. The Sani nudge hygiene system in a hospital patient room by Hüttel et al., CC BY 4.0PLOS ONE Analysis of social interactions and risk factors relevant to the spread of infectious diseases at hospitals and nursing homes
Ensuring the safety of healthcare workers is vital to overcome the ongoing COVID-19 pandemic. We here present an analysis of the social…
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PLOS ONE Cancer care disruption and reorganisation during the COVID-19 pandemic in Australia: A patient, carer and healthcare worker perspective
The COVID-19 pandemic has dramatically impacted cancer care worldwide. Disruptions have been seen across all facets of care. While the…
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Image creditHome Heart Rate Monitor - Finger Pulse Checker and a Stethoscope by www.doctor-4-u.co.uk, CC BY 2.0PLOS ONE Study protocol of the PEruvian Registry of ST-segment Elevation Myocardial Infarction II (PERSTEMI-II) study
Background: Myocardial infarction (MI) is the most prevalent cardiovascular disease globally and is considered a public health problem. In…
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PLOS ONE Performance of COVID-19 associated symptoms and temperature checking as a screening tool for SARS-CoV-2 infection
Introduction: Coronavirus disease-19 (COVID-19), which started in late December, 2019, has spread to affect 216 countries and territories…
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PLOS ONE Blood cancer care in a resource limited setting during the Covid-19 outbreak; a single center experience from Sri Lanka
Background: The Covid-19 pandemic has caused significant morbidity and mortality among patients with cancer. Most countries employed…
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Image creditInauguración del Hospital Municipal de Chiconcuac by Presidencia de la Repúblic, CC BY 2.0PLOS ONE The potential impact of triage protocols on racial disparities in clinical outcomes among COVID-positive patients in a large academic healthcare system
Background: The COVID-19 pandemic has had a devastating impact in the United States, particularly for Black populations, and has heavily…
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PLOS Pathogens Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients
Prior studies have demonstrated that immunologic dysfunction underpins severe illness in COVID-19 patients, but have lacked an in-depth…
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PLOS ONE Influence of coronavirus disease 2019 on myopic progression in children treated with low-concentration atropine
Purpose: The outbreak of coronavirus disease 2019 (COVID-19) has caused many children to stay indoors. Increased near work and insufficient…
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PLOS ONE Lack of effect on in-hospital mortality of drugs used during COVID-19 pandemic: Findings of the retrospective multicenter COVOCA study
Introduction: During COVID-19 pandemic, the use of several drugs has represented the worldwide clinical practice. However, though the…
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Image creditA doctor holding a magnifying glass. by Nenad Stojkovic, CC BY 2.0PLOS ONE Examining and investigating the impact of demographic characteristics and chronic diseases on mortality of COVID-19: Retrospective study
Background: Epidemiological features characterization of COVID-19 is highly important for developing and implementing effective control…
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Image creditStethoscope and heartbeats on red by Marco Verch, CC BY 2.0PLOS ONE Estrogen and COVID-19 symptoms: Associations in women from the COVID Symptom Study
It has been widely observed that adult men of all ages are at higher risk of developing serious complications from COVID-19 when compared…
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Image creditFig 2. Gross pathology of macroscopic hemorrhages by Santana et al., CC BY 4.0PLOS ONE Hemorrhagic and thrombotic manifestations in the central nervous system in COVID-19: A large observational study in the Brazilian Amazon with a complete autopsy series
SARS-CoV-2 affects mainly the lungs, however, other manifestations, including neurological manifestations, have also been described during…
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Image creditDoctor explains cardiogram data, consultation by Marco Verch, CC BY 2.0PLOS ONE Real-life use of tocilizumab with or without corticosteroid in hospitalized patients with moderate-to-severe COVID-19 pneumonia: A retrospective cohort study
Objective: To evaluate the effectiveness of Tocilizumab (with or without corticosteroids) in a real-life context among moderate-to-severe…
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Image creditFig 1. Emergency departments in the Netherlands (June 2020) by O’Connor et al., CC BY 4.0PLOS ONE Preparations of Dutch emergency departments for the COVID-19 pandemic: A questionnaire-based study
Background: The onset of the COVID-19 pandemic was characterized by rapid increases in Emergency department (ED) patient visits. EDs…
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Image creditMedical consultation by sergio santos, CC BY 2.0PLOS ONE Enabling teleophthalmology during the COVID-19 pandemic in the Province of Trento, Italy: Design and implementation of a mHealth solution
Background: Due to the many restrictions imposed during the COVID-19 emergency, the normal clinical activities have been stopped abruptly…
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Image creditWorking place of a coronavirus vaccination center worker by Marco Verch, CC BY 2.0PLOS ONE Statins use and COVID-19 outcomes in hospitalized patients
Background: There is an urgent need for novel therapeutic strategies for reversing COVID-19-related lung inflammation. Recent evidence has…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain 1.0PLOS ONE Elevated C-reactive protein in early COVID-19 predicts worse survival among hospitalized geriatric patients
Background: The objective of this cohort study was to determine whether elevated CRP in early COVID-19 was associated with 14-day mortality…
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Image creditGloves and disposable medical mask on a white background by Marco Verch, CC BY 2.0PLOS ONE Health knowledge, health behaviors and attitudes during pandemic emergencies: A systematic review
Background: People with good health knowledge present a conceptual and objective appropriation of general and specific health topics,…
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Image creditDoctor chest with stethoscope in pocket by www.authoritydental.org., CC BY 2.0PLOS ONE Nurses’ perspectives of taking care of patients with Coronavirus disease 2019: A phenomenological study
The pandemic of Coronavirus disease 2019 (COVID-19) has brought significant pressure on nurses globally as they are the frontline of care.…
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PLOS ONE Risk factors for hospitalization among persons with COVID-19—Colorado
Background: Most current evidence on risk factors for hospitalization because of coronavirus disease 2019 (COVID-19) comes from studies…
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PLOS ONE Pulmonary function and six-minute-walk test in patients after recovery from COVID-19: A prospective cohort study
Objectives: To study abnormality of spirometry, six-minute walk distance, and chest radiograph among patients recovered from Coronavirus…
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PLOS ONE Physiological respiratory parameters in pre-hospital patients with suspected COVID-19: A prospective cohort study
Background: The COVID-19 pandemic has presented emergency medical services (EMS) worldwide with the difficult task of identifying patients…
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PLOS ONE Possibility of deterioration of respiratory status when steroids precede antiviral drugs in patients with COVID-19 pneumonia: A retrospective study
Introduction: Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2. Although most patients with…
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PLOS ONE Impacts of COVID-19 on essential health services in Tigray, Northern Ethiopia: A pre-post study
Background: COVID-19 has proved to have an indirect impact on essential health services in several parts of the world which could lead to…
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Image creditFig 2. Assessment of methodological quality by Du et al., CC BY 4.0PLOS ONE Add-on effect of Chinese herbal medicine in the treatment of mild to moderate COVID-19: A systematic review and meta-analysis
Introduction: Coronavirus disease 2019 (COVID-19) has emerged as a global pandemic since its outbreak in Wuhan, China. It is an urgent task…
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Image creditWorking place of a coronavirus vaccination center worker by Marco Verch, CC BY 2.0PLOS ONE COVID-19 pandemic: Impact on the management of patients with hepatocellular carcinoma at a tertiary care hospital
Background: Patients with hepatocellular carcinoma (HCC) represent a vulnerable population potentially negatively affected by…
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PLOS ONE D-dimer as a biomarker for assessment of COVID-19 prognosis: D-dimer levels on admission and its role in predicting disease outcome in hospitalized patients with COVID-19
Introduction: Coronavirus Disease 2019 is a primarily respiratory illness that can cause thrombotic disorders. Elevation of D-dimer is a…
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PLOS ONE Dysregulated plasma lipid mediator profiles in critically ill COVID-19 patients
Coronavirus disease (COVID)-19, as a result of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, has been the direct…
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PLOS ONE Persisting symptoms three to eight months after non-hospitalized COVID-19, a prospective cohort study
Long-COVID-19 is a proposed syndrome negatively affecting the health of COVID-19 patients. We present data on self-rated health three to…
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Image creditWorking place of a coronavirus vaccination center worker by Marco Verch, CC BY 2.0PLOS ONE Health emergencies and interoceptive sensibility modulate the perception of non-evidence-based drug use: Findings from the COVID-19 outbreak
Scientific evidence plays an important role in the therapeutic decision-making process. What happens when physicians are forced to make…
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PLOS ONE Don’t close the book on tocilizumab for the treatment of severe COVID-19 pneumonia–the jury is still out: The Kuwait experience
Purpose: This cross-sectional observational study aims to report preliminary data from the first experience using tocilizumab for patients…
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Image creditFig 1. VA distribution of the patients by Li et al., CC BY 4.0PLOS ONE The impact of the COVID-19 pandemic lockdown on rhegmatogenous retinal detachment services—Experiences from the Tongren eye center in Beijing
Purpose: To investigate the impact on services for rhegmatogenous retinal detachment (RRD) patients during the COVID-19 (2019coronal virus…
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PLOS ONE COVID19-associated cardiomyocyte dysfunction, arrhythmias and the effect of Canakinumab
Background: Cardiac injury associated with cytokine release frequently occurs in SARS-CoV-2 mediated coronavirus disease (COVID19) and…
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PLOS ONE The impact of the Covid-19 pandemic on quality of life in skin cancer patients
With more than 82 million cases worldwide and almost two million deaths, the Covid-19 global pandemic shows little sign of abating.…
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PLOS ONE The impact of the COVID-19 pandemic on microbial keratitis presentation patterns
Background: Microbial keratitis (MK) is the most common non-surgical ophthalmic emergency, and can rapidly progress, causing irreversible…
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Image creditFig 1. Relative importance of predictors of cardiovascular involvement by Beck-Friis et al., CC BY 4.0PLOS ONE No difference in biomarkers of ischemic heart injury and heart failure in patients with COVID-19 who received treatment with chloroquine phosphate and those who did not
Background: Chloroquine was promoted as a COVID-19 therapeutic early in the pandemic. Most countries have since discontinued the use of…
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Image creditMedical consultation by nursingschoolsnearme.com, CC BY 2.0PLOS ONE Obesity is independently associated with septic shock, renal complications, and mortality in a multiracial patient cohort hospitalized with COVID-19
Background: Obesity has emerged as a risk factor for severe coronavirus disease 2019 (COVID-19) infection. To inform treatment…
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PLOS ONE Efficacy of a four-tier infection response system in the emergency department during the coronavirus disease-2019 outbreak
Introduction: The coronavirus disease (COVID-19) pandemic has delayed the management of other serious medical conditions. This study…
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Image creditDoctor chest with stethoscope in pocket by Authority Dental, CC BY 2.0PLOS ONE Serological prevalence of SARS-CoV-2 infection and associated factors in healthcare workers in a “non-COVID” hospital in Mexico City
Background: Mexico is one of the countries with the highest number of deaths from the COVID-19 pandemic. In spite of this high mortality,…
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PLOS ONE Evaluation of the epidemiological behavior of mortality due to COVID-19 in Brazil: A time series study
The World Health Organization declared, at the end of 2019, a pandemic caused by SARS-CoV-2, a virus that causes Coronavirus…
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Image creditStethoscope, pills, and syringe on white table by Authority Dental, CC BY 2.0PLOS ONE Changes in the top 25 reasons for primary care visits during the COVID-19 pandemic in a high-COVID region of Canada
Purpose: We aimed to determine the degree to which reasons for primary care visits changed during the COVID-19 pandemic. Methods: We used…
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PLOS ONE Combining IL-6 and SARS-CoV-2 RNAaemia-based risk stratification for fatal outcomes of COVID-19
Background: The coronavirus disease 2019 (COVID-19) pandemic rapidly increases the use of mechanical ventilation (MV). Such cases further…
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Image creditFig 1. Description of the cohort by Shoaib et al., CC BY 4.0PLOS ONE COVID-19 severity: Studying the clinical and demographic risk factors for adverse outcomes
Background: The primary goal of the presented cross-sectional observational study was to determine the clinical and demographic risk…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public DomainPLOS ONE COVID-19 and cause of pregnancy loss during the pandemic: A systematic review
Introduction: The association between Coronavirus Disease 2019 (COVID-19) and abortion has been debated since the beginning of the COVID-19…
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Image creditIntravenous therapy (IV) drip by Robert Geiger, CC BY 2.0PLOS ONE The tumor patient in the COVID-19 pandemic–an interview-based study of 30 patients undergoing systemic antiproliferative therapy
Introduction: Five months after COVID-19 first occurred and protective regulations were introduced, patients at three outpatient…
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PLOS ONE Characteristics and outcomes of acute kidney injury in hospitalized COVID-19 patients: A multicenter study by the Turkish society of nephrology
Background: Acute kidney injury (AKI) is common in coronavirus disease-2019 (COVID-19) and the severity of AKI is linked to adverse…
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PLOS Pathogens Intranasal type I interferon treatment is beneficial only when administered before clinical signs onset in the SARS-CoV-2 hamster model
Impaired type I interferons (IFNs) production or signaling have been associated with severe COVID-19, further promoting the evaluation of…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain Mark 1.0PLOS Biology Challenges in interpreting cytokine data in COVID-19 affect patient care and management
Challenges in using cytokine data are limiting Coronavirus Disease 2019 (COVID-19) patient management and comparison among different…
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PLOS ONE A new haematocytometric index: Predicting severity and mortality risk value in COVID-19 patients
Introduction: Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 virus, is a major public health concern spanning from healthy…
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PLOS ONE 6-month mortality and readmissions of hospitalized COVID-19 patients: A nationwide cohort study of 8,679 patients in Germany
Background: COVID-19 frequently necessitates in-patient treatment and in-patient mortality is high. Less is known about the long-term…
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PLOS ONE Preterm birth is not associated with asymptomatic/mild SARS-CoV-2 infection per se: Pre-pregnancy state is what matters
Evidence for the real impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on preterm birth is unclear, as…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain Mark 1.0PLOS ONE Anxious temperament and cyberchondria as mediated by fear of COVID-19 infection: A cross-sectional study
This study’s main goal was to evaluate the association between anxious temperament and the fear of COVID-19-related self-infection and…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain Mark 1.0PLOS Neglected Tropical Diseases Use of minimally invasive autopsy during the COVID-19 pandemic and its possibilities in the context of developing countries
…
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Image creditNew Monitor/New Desk by Dave Fayram, CC BY 2.0PLOS ONE Application of telemedicine in the COVID-19 epidemic: An analysis of Gansu Province in China
This paper analyzes the application of various telemedicine services in Gansu Province, China during the COVID-19 epidemic, and summarizes…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain
Background: Whether immunosuppressed (IS) patients have a worse prognosis of COVID-19 compared to non-IS patients is not known. The aim of…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE Examining the potential benefits of the influenza vaccine against SARS-CoV-2: A retrospective cohort analysis of 74,754 patients
Introduction: Recently, several single center studies have suggested a protective effect of the influenza vaccine against severe acute…
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PLOS ONE Reduction in hospitalised COPD exacerbations during COVID-19: A systematic review and meta-analysis
Background: Reports have suggested a reduction in exacerbations of chronic obstructive pulmonary disease (COPD) during the coronavirus…
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PLOS ONE Risk factors for severity of COVID-19 in hospital patients age 18–29 years
Background: Since February 2020, over 2.5 million Texans have been diagnosed with COVID-19, and 20% are young adults at risk for SARS-CoV-2…
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Image creditImage title by agilemktg1, Public Domain Mark 1.0PLOS ONE Trends in COVID-19 cases and clinical management in Veterans Health Administration medical facilities: A national cohort study
Objective: We explored longitudinal trends in sociodemographic characteristics, reported symptoms, laboratory findings, pharmacological and…
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Image creditFig 1. Timeline of the study by Arévalos et al., CC BY 4.0PLOS ONE Long-term effects of coronavirus disease 2019 on the cardiovascular system, CV COVID registry: A structured summary of a study protocol
Background: Patients presenting with the coronavirus-2019 disease (COVID-19) may have a high risk of cardiovascular adverse events,…
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PLOS ONE A national retrospective study of the association between serious operational problems and COVID-19 specific intensive care mortality risk
Objectives: To describe the relationship between reported serious operational problems (SOPs), and mortality for patients with COVID-19…
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PLOS ONE Topological network based drug repurposing for coronavirus 2019
The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has become the current health concern and…
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PLOS ONE Streamlining brain tumor surgery care during the COVID-19 pandemic: A case-control study
Background: The COVID-19 pandemic forced a reconsideration of surgical patient management in the setting of scarce resources and risk of…
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PLOS Neglected Tropical Diseases The influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19: A prospective real-world cohort study
Background: Protective effects of Bacillus Calmette–Guérin (BCG) vaccination and clofazimine and dapsone treatment against severe acute…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain Mark 1.0PLOS ONE High mortality among kidney transplant recipients diagnosed with coronavirus disease 2019: Results from the Brazilian multicenter cohort study
Background: Kidney transplant (KT) recipients are considered a high-risk group for unfavorable outcomes in the course of coronavirus…
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PLOS ONE Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19
Background: Limited therapeutic options exist for coronavirus disease 2019 (COVID-19). COVID-19 convalescent plasma (CCP) is a potential…
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PLOS ONE Lower serum 25(OH)D levels associated with higher risk of COVID-19 infection in U.S. Black women
Objective: Limited evidence suggests that higher levels of serum vitamin D (25(OH)D) protect against SARS-CoV-2 virus (COVID-19) infection.…
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Image creditFig 4. Cumulative frequency of observed sedation depth by Flinspach et al., CC BY 4.0PLOS ONE High sedation needs of critically ill COVID-19 ARDS patients—A monocentric observational study
Background: Therapy of severely affected coronavirus patient, requiring intubation and sedation is still challenging. Recently,…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, Public Domain Mark 1.0PLOS ONE COVID-19 severity and mortality in multiple sclerosis are not associated with immunotherapy: Insights from a nation-wide Austrian registry
Background: The COVID-19 pandemic challenges neurologists in counselling patients with multiple sclerosis (pwMS) regarding their risk by…
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PLOS ONE Hematological abnormalities and comorbidities are associated with COVID-19 severity among hospitalized patients: Experience from Bangladesh
Background: The hematological abnormalities are assumed to be involved in the disease progression of COVID-19. However, the actual…
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PLOS ONE Facing the COVID-19 pandemic inside maternities in Brazil: A mixed-method study within the REBRACO initiative
Introduction: COVID-19 pandemic posed major challenges in obstetric health care services. Preparedness, development, and implementation of…
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PLOS ONE Rethinking remdesivir for COVID-19: A Bayesian reanalysis of trial findings
Background: Following testing in clinical trials, the use of remdesivir for treatment of COVID-19 has been authorized for use in parts of…
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Image creditFig 1. Experimental model simulating endoscopic examination by Keil et al., CC BY 4.0PLOS ONE Commonly available but highly effective protection against SARS-CoV-2 during gastrointestinal endoscopies
Background and aims: SARS-CoV-2 is a worldwide serious health problem. The aim of this study was to demonstrate the number of potentially…
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Image creditFig 1. Clinical features of the cohort by Meis-Pinheiro et al., CC BY 4.0PLOS ONE Clinical characteristics of COVID-19 in older adults. A retrospective study in long-term nursing homes in Catalonia
The natural history of COVID-19 and predictors of mortality in older adults need to be investigated to inform clinical operations and…
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PLOS ONE Mortality and associated risk factors of COVID-19 infection in dialysis patients in Qatar: A nationwide cohort study
Context: Patients on maintenance dialysis are more susceptible to COVID-19 and its severe form. We studied the mortality and associated…
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PLOS ONE Both high and low pre-infection glucose levels associated with increased risk for severe COVID-19: New insights from a population-based study
Importance: Patients with diabetes are known to be at increased risk for infections including severe coronavirus disease 2019 (COVID-19)…
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Image creditImage title by National Institute of Allergy and Infectious Diseases, NIH, Public Domain Mark 1.0PLOS ONE The impact of medical teleconsultations on general practitioner-patient communication during COVID- 19: A case study from Poland
According to the outbreak of the Covid-19 pandemic, medical teleconsultations using various technologies have become an important tool to…
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PLOS ONE Knowledge, attitude and preventive practice towards COVID-19 and associated factors among outpatient service visitors at Debre Markos compressive specialized hospital, north-west Ethiopia, 2020
Background: COVID-19 is an emerging infectious disease which is a major public health problem worldwide. Given the serious threats imposed…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, Public Domain Mark 1.0PLOS ONE Manifestations of renal system involvement in hospitalized patients with COVID-19 in Saudi Arabia
Background: Although COVID-19 is an acute disease that usually resolves rapidly in most cases, the disease can be fatal and has a mortality…
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Image creditImage title by NIAID/NIH, Public Domain Mark 1.0PLOS ONE Relation of prior statin and anti-hypertensive use to severity of disease among patients hospitalized with COVID-19: Findings from the American Heart Association’s COVID-19 Cardiovascular Disease Registry
Background: Statins have anti-inflammatory and immunomodulatory effects that may reduce the severity of coronavirus disease 2019…
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Image creditFig 2. The proportion of municipalities attended by TRS in Brazil by region by Montelongo et al., CC BY 4.0PLOS ONE The management of COVID-19 cases through telemedicine in Brazil
In Dec 2020 Brazil became one of the worldwide epicenters of the COVID-19 pandemic with more than 7.2M reported cases. Brazil has a large…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain 1.0PLOS ONE Pre-hospital causes for delayed arrival in acute ischemic stroke before and during the COVID-19 pandemic: A study at two stroke centers in Egypt
Background: In the current study we investigated the causes of pre-hospital delay as this can compromise the patient’s chance to receive…
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Image creditFig 1. Immune response to SARS-CoV-2 infection model schematic by Jenner et al., CC BY 4.0PLOS Pathogens COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomes
To understand the diversity of immune responses to SARS-CoV-2 and distinguish features that predispose individuals to severe COVID-19, we…
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Image creditbacteria/viruses by John Voo, CC BY 2.0PLOS ONE Bacterial superinfection in adults with COVID-19 hospitalized in two clinics in Medellín-Colombia, 2020
COVID-19 represents high morbidity and mortality, its complications and lethality have increased due to bacterial superinfections. We…
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Image creditFig 2. Outcome of the patients in each group by Miki et al., CC BY 4.0PLOS ONE On-admission SARS-CoV-2 RNAemia as a single potent predictive marker of critical condition development and mortality in COVID-19
Background: This study aimed to clarify how SARS-CoV-2 RNAemia is related to COVID-19 critical condition development and mortality in…
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PLOS ONE Intention to receive vaccine against COVID-19 and associated factors among health professionals working at public hospitals in resource limited settings
Backgrounds: Health professionals are among the frontline of COVID-19 pandemic exposure and identified as a priority target group that need…
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Image creditInauguración del Hospital Municipal de Chiconcuac by Presidencia de la República Mexicana, CC BY 2.0PLOS ONE Burden of post-COVID-19 syndrome and implications for healthcare service planning: A population-based cohort study
Background: Longer-term consequences after SARS-CoV-2 infection are becoming an important burden to societies and healthcare systems. Data…
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Image creditFig 1. Subgroup breakdown for analyses. by Brojakowska et al., CC BY 4.0PLOS ONE Comorbidities, sequelae, blood biomarkers and their associated clinical outcomes in the Mount Sinai Health System COVID-19 patients
With the continuing rise of SARS-CoV2 infection globally and the emergence of various waves in different countries, understanding…
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PLOS ONE The impact of the COVID-19 pandemic on waiting times for elective surgery patients: A multicenter study
Background: A concern has been that health care reorganizations during the first COVID-19 wave have led to delays in elective surgeries,…
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PLOS ONE Dexamethasone may improve severe COVID-19 via ameliorating endothelial injury and inflammation: A preliminary pilot study
Dexamethasone provides benefits in patients with coronavirus disease 2019 (COVID-19), although data regarding immunological profiles and…
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PLOS ONE Identifying factors that nurses consider in the decision-making process related to patient care during the COVID-19 pandemic
Background: Nurse identification of patient deterioration is critical, particularly during the COVID-19 pandemic, as patients can…
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PLOS ONE Characterization of antibody response in asymptomatic and symptomatic SARS-CoV-2 infection
SARS-CoV-2 pandemic is causing high morbidity and mortality burden worldwide with unprecedented strain on health care systems. To…
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Image creditFig 1. Illustration of the modeling framework. by Mahdavi et al., CC BY 4.0PLOS ONE A machine learning based exploration of COVID-19 mortality risk
Early prediction of patient mortality risks during a pandemic can decrease mortality by assuring efficient resource allocation and…
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PLOS Medicine Sales of antibiotics and hydroxychloroquine in India during the COVID-19 epidemic: An interrupted time series analysis
Background: We assessed the impact of the coronavirus disease 2019 (COVID-19) epidemic in India on the consumption of antibiotics and…
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PLOS ONE High rate of HSV-1 reactivation in invasively ventilated COVID-19 patients: Immunological findings
SARS-CoV-2 infection can lead to severe acute respiratory distress syndrome with the need of invasive ventilation. Pulmonary herpes…
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PLOS ONE How risky is it to visit a supermarket during the pandemic?
We performed large-scale numerical simulations using a composite model to investigate the infection spread in a supermarket during a…
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PLOS ONE A public survey of traditional, complementary and integrative medicine use during the COVID-19 outbreak in Hong Kong
Background: During COVID-19, the public actively sought non-pharmacological and self-management approaches to prevent infection. Little is…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE The impact of the SARS-COV2 infection on the disorder of consciousness rehabilitation unit
Background and objective: Disorders of consciousness include coma (cannot be aroused, eye remain closed), vegetative state—VS (can appear…
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PLOS ONE Evaluating the association between COVID-19 and psychiatric presentations, suicidal ideation in an emergency department
Objective: To estimate the association between COVID-19 and Emergency Department (ED) psychiatric presentations, including suicidal…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE Biomarkers of cytokine storm as red flags for severe and fatal COVID-19 cases: A living systematic review and meta-analysis
Objective: To describe the laboratory parameters and biomarkers of the cytokine storm syndrome associated with severe and fatal COVID-19…
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PLOS ONE COVID-19 laboratory preparedness and response in the Americas Region: Lessons learned
By the time the etiologic agent of the COVID-19 was identified as a novel coronavirus, no country in the Americas Region had laboratory…
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PLOS ONE Comparison of three serological chemiluminescence immunoassays for SARS-CoV-2, and clinical significance of antibody index with disease severity
Background: The clinical significance of the quantitative value of antibodies in severe acute respiratory syndrome coronavirus 2…
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PLOS ONE COVID-19 and pregnancy: An umbrella review of clinical presentation, vertical transmission, and maternal and perinatal outcomes
Background: We conducted an overview of systematic reviews (SRs) summarizing the best evidence regarding the effect of COVID-19 on maternal…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE Neutrophil-to-lymphocyte ratio, platelets-to-lymphocyte ratio, and eosinophils correlation with high-resolution computer tomography severity score in COVID-19 patients
Inflammation has an important role in the progression of various viral pneumonia, including COVID-19. Circulating biomarkers that can…
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Image creditFig 1. Pattern of worry scores of COVID-19 crisis by hospital. by Deressa et al., CC BY 4.0PLOS ONE Risk perceptions and preventive practices of COVID-19 among healthcare professionals in public hospitals in Addis Ababa, Ethiopia
Healthcare professionals are at higher risk of contracting the new coronavirus disease 2019 (COVID-19). Although appropriate preventive…
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PLOS ONE Impact of Covid-19 on attendances for a 1st episode of reduced fetal movements: A retrospective observational study
Background: Prior studies have demonstrated an increased stillbirth rate. It was suggested that the COVID-19 pandemic may have impacted on…
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PLOS ONE Improved outcomes over time for adult COVID-19 patients with acute respiratory distress syndrome or acute respiratory failure
Background: COVID-19’s pulmonary manifestations are broad, ranging from pneumonia with no supplemental oxygen requirements to acute…
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PLOS ONE Estimating ventilation rates in rooms with varying occupancy levels: Relevance for reducing transmission risk of airborne pathogens
Background: In light of the role that airborne transmission plays in the spread of SARS-CoV-2, as well as the ongoing high global mortality…
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Image creditSyringe and Vaccine by NIH/NIAID, CC BY 2.0PLOS ONE Determinant of intention to receive COVID-19 vaccine among school teachers in Gondar City, Northwest Ethiopia
Background: Scientists across the world are working on innovating a successful vaccine that will save lives and end COVID-19 pandemic.…
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Image creditFig 3. Statin use, after hospitalization. by Chow et al., CC BY 4.0PLOS ONE The protective association between statins use and adverse outcomes among COVID-19 patients: A systematic review and meta-analysis
Introduction: Statins may reduce a cytokine storm, which has been hypothesized as a possible mechanism of severe COVID-19 pneumonia. The…
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PLOS Pathogens Dating first cases of COVID-19
Questions persist as to the origin of the COVID-19 pandemic. Evidence is building that its origin as a zoonotic spillover occurred prior…
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PLOS Computational Biology Contrasting factors associated with COVID-19-related ICU admission and death outcomes in hospitalised patients by means of Shapley values
Identification of those at greatest risk of death due to the substantial threat of COVID-19 can benefit from novel approaches to…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE COVID-19 pneumonia in Galicia (Spain): Impact of prognostic factors and therapies on mortality and need for mechanical ventilation
Introduction: This study was aimed to identify risk factors associated with unfavorable outcomes (composite outcome variable: mortality and…
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Image creditFig 2. Map of national seroprevalence studies reporting population-wide estimates. by Natural Earth and Bobrovitz et al., CC BY 4.0PLOS ONE Global seroprevalence of SARS-CoV-2 antibodies: A systematic review and meta-analysis
Background: Many studies report the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies. We aimed to…
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PLOS ONE Body mass index and severity/fatality from coronavirus disease 2019: A nationwide epidemiological study in Korea
Objective: Obesity has been reported as a risk factor for severe coronavirus disease 2019 (COVID-19) in recent studies. However, the…
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PLOS ONE Blood coagulation parameter abnormalities in hospitalized patients with confirmed COVID-19 in Ethiopia
Background: Coagulopathy and thromboembolic events are among the complications of Corona Virus disease 2019 (COVID-19). Abnormal…
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Image creditFig 1. Logistic growth curve of the COVID-19 pandemic. by Kaimann and Tanneberg, CC BY 4.0PLOS ONE What containment strategy leads us through the pandemic crisis? An empirical analysis of the measures against the COVID-19 pandemic
Since January 2020, the COVID-19 outbreak has been progressing at a rapid pace. To keep the pandemic at bay, countries have implemented…
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PLOS ONE Predictors of severity and mortality among patients hospitalized with COVID-19 in Rhode Island
Background: In order for healthcare systems to prepare for future waves of COVID-19, an in-depth understanding of clinical predictors is…
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PLOS ONE An in vitro study of dual drug combinations of anti-viral agents, antibiotics, and/or hydroxychloroquine against the SARS-CoV-2 virus isolated from hospitalized patients in Surabaya, Indonesia
A potent therapy for the infectious coronavirus disease COVID-19 is urgently required with, at the time of writing, research in this area…
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PLOS ONE Association of the past epidemic of Mycobacterium tuberculosis with mortality and incidence of COVID-19
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created…
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Image creditFig 1. Culminating measures model for the general population. by Shumway et al., CC BY 4.0PLOS ONE Predictors of compliance with COVID-19 related non-pharmaceutical interventions among university students in the United States
The world is currently dealing with a devastating pandemic. Although growing COVID-19 case numbers, deaths, and hospitalizations are…
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PLOS ONE COVID-19 in persons aged 70+ in an early affected German district: Risk factors, mortality and post-COVID care needs—A retrospective observational study of hospitalized and non-hospitalized patients
Background: Cohorts of hospitalized COVID-19 patients have been studied in several countries since the beginning of the pandemic. So far,…
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PLOS Computational Biology Estimating the cumulative incidence of COVID-19 in the United States using influenza surveillance, virologic testing, and mortality data: Four complementary approaches
Effectively designing and evaluating public health responses to the ongoing COVID-19 pandemic requires accurate estimation of the…
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Image creditFig 1. Pathogen reproductive number, Rt, plotted against the ratio of contacts needing tracing to contact tracing capacity for variable delays (1/τIs) of 1–5 and 10 days between case symptom onset and the start of contact tracing (including getting tested and receiving result). by Gardner and Kilpatrick, CC BY 4.0PLOS Computational Biology Contact tracing efficiency, transmission heterogeneity, and accelerating COVID-19 epidemics
Simultaneously controlling COVID-19 epidemics and limiting economic and societal impacts presents a difficult challenge, especially with…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public DomainPLOS ONE Post-infectious and post-acute sequelae of critically ill adults with COVID-19
Background: Data on the post-acute and post-infectious complications of patients who have recovered from severe coronavirus disease 2019…
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PLOS ONE Predictors of incident viral symptoms ascertained in the era of COVID-19
Background: In the absence of universal testing, effective therapies, or vaccines, identifying risk factors for viral infection,…
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PLOS ONE Feasibility of collecting and processing of COVID-19 convalescent plasma for treatment of COVID-19 in Uganda
Introduction: Evidence that supports the use of COVID-19 convalescent plasma (CCP) for treatment of COVID-19 is increasingly emerging.…
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PLOS ONE Duration of SARS-CoV-2 shedding: A population-based, Canadian study
Introduction: There is an evidence gap regarding the duration of SARS-CoV-2 shedding and of its variability across different care settings…
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Image creditFig 1. Patient distribution of the 4704 included patients in Germany. by Gessler et al., CC BY 4.0PLOS ONE Clinical outcome, risk assessment, and seasonal variation in hospitalized COVID-19 patients—Results from the CORONA Germany study
Background: After one year of the pandemic and hints of seasonal patterns, temporal variations of in-hospital mortality in COVID-19 are…
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PLOS ONE A first analysis of excess mortality in Switzerland in 2020
Objective: To quantify excess all-cause mortality in Switzerland in 2020, a key indicator for assessing direct and indirect consequences of…
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PLOS ONE Reduced muscle mass as predictor of intensive care unit hospitalization in COVID-19 patients
Purpose: To evaluate if reduced muscle mass, assessed with Computed Tomography (CT), is a predictor of intensive care unit (ICU)…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public DomainPLOS ONE Reported health and social consequences of the COVID-19 pandemic on vulnerable populations and implemented solutions in six West African countries: A media content analysis
Coronavirus has spread worldwide with over 140 million cases and resulting in more than 3 million deaths between November 2019 to April…
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Image creditFig 2. Forest plot of the prevalence of COVID-19 in ESRD patients with RRT. by Nopsopon et al., CC BY 4.0PLOS Neglected Tropical Diseases Covid-19 in end-stage renal disease patients with renal replacement therapies: A systematic review and meta-analysis
Background: The novel coronavirus (COVID-19), caused by SARS-CoV-2, showed various prevalence and case-fatality rates (CFR) among patients…
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PLOS ONE The selection of indicators from initial blood routine test results to improve the accuracy of early prediction of COVID-19 severity
The global pandemic of COVID-19 poses a huge threat to the health and lives of people all over the world, and brings unprecedented…
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PLOS ONE Sex differences in the incidence, mortality, and fatality of COVID-19 in Peru
Background: There is a worrying lack of epidemiological data on the sex differential in COVID-19 infection and death rates between the…
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PLOS ONE Ayurveda botanicals in COVID-19 management: An in silico multi-target approach
The Coronavirus disease (COVID-19) caused by the virus SARS-CoV-2 has become a global pandemic in a very short time span. Currently, there…
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Image creditFig 1. Mortality Trends in COVID-19 admissions. by Coppock et al., CC BY 4.0PLOS ONE COVID-19 treatment combinations and associations with mortality in a large multi-site healthcare system
Introduction: During the early months of the COVID-19 pandemic, mortality associated with the disease declined in the United States. The…
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Image creditFig 3. IgG levels in the patients during the three visits. by Alzaabi et al., CC BY 4.0PLOS ONE Longitudinal changes in IgG levels among COVID-19 recovered patients: A prospective cohort study
Objectives: To quantify SARS-CoV2 IgG antibody titers over time and assess the longevity of the immune response in a multi-ethnic…
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PLOS ONE Inactivation of SARS-CoV-2 virus in saliva using a guanidium based transport medium suitable for RT-PCR diagnostic assays
Background: Upper respiratory samples used to test for SARS-CoV-2 virus may be infectious and present a hazard during transport and…
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PLOS ONE Stay-at-home orders associate with subsequent decreases in COVID-19 cases and fatalities in the United States
Governments issue “stay-at-home” orders to reduce the spread of contagious diseases, but the magnitude of such orders’ effectiveness…
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PLOS ONE Automatic algorithm for quantifying lung involvement in patients with chronic obstructive pulmonary disease, infection with SARS-CoV-2, paracoccidioidomycosis and no lung disease patients
In this work, we aimed to develop an automatic algorithm for the quantification of total volume and lung impairments in four different…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public DomainPLOS ONE Nurses’ core disaster-response competencies for combating COVID-19—A cross-sectional study
The core competencies in disaster nursing, nurses’ roles in disaster management and the potential barriers are assessed with a view to…
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Image creditFig 1. Stay-at-home measure and number of new infections, Tokyo. by Watanabe and Yabu, CC BY 4.0PLOS ONE Japan’s voluntary lockdown
Japan’s government has taken a number of measures, including declaring a state of emergency, to combat the spread COVID-19. We examine the…
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PLOS ONE COVI-Prim survey: Challenges for Austrian and German general practitioners during initial phase of COVID-19
Background: Coronavirus disease 2019 (COVID-19) represents a significant challenge to health care systems around the world. A…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public DomainPLOS ONE Low level SARS-CoV-2 RNA detected in plasma samples from a cohort of Nigerians: Implications for blood transfusion
The present global pandemic triggered by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has lingered for over a year in…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public DomainPLOS ONE Investigation of superspreading COVID-19 outbreak events in meat and poultry processing plants in Germany: A cross-sectional study
Since May 2020, several COVID-19 outbreaks have occurred in the German meat industry despite various protective measures, and temperature…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE Seroprevalence of anti-SARS-CoV-2 IgG antibodies in the staff of a public school system in the midwestern United States
Since March 2020, the United States has lost over 580,000 lives to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which…
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PLOS ONE Simulated sunlight decreases the viability of SARS-CoV-2 in mucus
The novel coronavirus, SARS-CoV-2, has spread into a pandemic since its emergence in Wuhan, China in December of 2019. This has been…
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Image creditFig 1. Variability in SARS-CoV-2 IgG antibody response. by Schaefer et al., CC BY 4.0PLOS ONE Corona Virus Disease-19 serology, inflammatory markers, hospitalizations, case finding, and aging
Most deaths from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection occur in older subjects. We assessed the utility…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE Screening for SARS-CoV-2 by RT-PCR: Saliva or nasopharyngeal swab? Rapid review and meta-analysis
Background: Diagnosis of COVID-19 in symptomatic patients and screening of populations for SARS-CoV-2 infection require access to…
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PLOS ONE Time to recovery from COVID-19 and its predictors among patients admitted to treatment center of Wollega University Referral Hospital (WURH), Western Ethiopia: Survival analysis of retrospective cohort study
Introduction: Despite its alarming spread throughout the world, no effective drug and vaccine is discovered for COVID-19 so far. According…
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Image creditFig 1. Distribution of treatment modalities over time. by Malhani et al., CC BY 4.0PLOS ONE Combination of (interferon beta-1b, lopinavir/ritonavir and ribavirin) versus favipiravir in hospitalized patients with non-critical COVID-19: A cohort study
Objectives: Our study aims at comparing the efficacy and safety of IFN-based therapy (lopinavir/ritonavir, ribavirin, and interferon β-1b)…
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PLOS ONE Renal allograft function in kidney transplant recipients infected with SARS-CoV 2: An academic single center experience
Background: Kidney transplant recipients are a unique cohort in regard to SARS-CoV 2 susceptibility and clinical course, owing to their…
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PLOS ONE Detection of SARS-CoV-2 using qRT-PCR in saliva obtained from asymptomatic or mild COVID-19 patients, comparative analysis with matched nasopharyngeal samples
Objectives: The accurate detection of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is essential for the diagnosis of…
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PLOS ONE Lack of efficacy of hydroxychloroquine and azithromycin in patients hospitalized for COVID-19 pneumonia: A retrospective study
Background: Hydroxychloroquine combined with azithromycin (HCQ/AZI) has initially been used against coronavirus disease-2019 (COVID-19). In…
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PLOS ONE Identification and evaluation of the inhibitory effect of Prunella vulgaris extract on SARS-coronavirus 2 virus entry
Until now, antiviral therapeutic agents are still urgently required for treatment or prevention of SARS-coronavirus 2 (SCoV-2) virus…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE Influence of thromboembolic events in the prognosis of COVID-19 hospitalized patients. Results from a cross sectional study
Background: COVID-19 may predispose to both venous and arterial thromboembolism event (TEE). Reports on the prevalence and prognosis of…
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PLOS ONE Social, economic, and environmental factors influencing the basic reproduction number of COVID-19 across countries
Objective: To assess whether the basic reproduction number (R0) of COVID-19 is different across countries and what national-level…
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PLOS ONE Severe COVID-19 pneumonia: Perfusion analysis in correlation with pulmonary embolism and vessel enlargement using dual-energy CT data
Background: Gas exchange in COVID-19 pneumonia is impaired and vessel obstruction has been suspected to cause ventilation-perfusion…
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Image creditFig 1. The global model collects local models updates. by Abdul Salam et al., CC BY 4.0PLOS ONE COVID-19 detection using federated machine learning
The current COVID-19 pandemic threatens human life, health, and productivity. AI plays an essential role in COVID-19 case classification…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE Excess mortality by specific causes of deaths in the city of São Paulo, Brazil, during the COVID-19 pandemic
Background: To investigate the excess of deaths by specific causes, in the first half of 2020 in the city of São Paulo-Brazil, during the…
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Image creditFig 3. Representative case without COVID-19 pneumonia. by Hwang et al., CC BY 4.0PLOS ONE COVID-19 pneumonia on chest X-rays: Performance of a deep learning-based computer-aided detection system
Chest X-rays (CXRs) can help triage for Coronavirus disease (COVID-19) patients in resource-constrained environments, and a computer-aided…
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PLOS Pathogens Detection of R.1 lineage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with spike protein W152L/E484K/G769V mutations in Japan
We aimed to investigate novel emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages in Japan that harbor variants…
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PLOS ONE Meteorological factors against COVID-19 and the role of human mobility
In the vein of recent empirical literature, we reassessed the impact of weather factors on Covid-19 daily cases and fatalities in a panel…
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PLOS ONE Excess mortality associated with the COVID-19 pandemic among Californians 18–65 years of age, by occupational sector and occupation: March through November 2020
Background: Though SARS-CoV-2 outbreaks have been documented in occupational settings and in-person essential work has been suspected as a…
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PLOS ONE Characterization of dysphagia and laryngeal findings in COVID-19 patients treated in the ICU—An observational clinical study
Background: Dysphagia appears to be common in patients with severe COVID-19. Information about the characteristics of dysphagia and…
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PLOS ONE Plasma ACE2 predicts outcome of COVID-19 in hospitalized patients
Aims: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin converting enzyme 2 (ACE2) enabling entrance of the…
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PLOS ONE Assessment of depressive symptoms in patients with COVID-19 during the second wave of epidemic in Myanmar: A cross-sectional single-center study
Background: Coronavirus disease 2019 (COVID-19) pandemic has had a great impact on every aspect of society. All countries launched…
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PLOS ONE End-stage kidney disease and COVID-19 in an urban safety-net hospital in Boston, Massachusetts
Introduction: End-stage kidney disease (ESKD) patients are at a high risk for Coronavirus Disease 2019 (COVID-19). In this study, we…
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Image creditFig 1. Schematic diagram of the contact tracing model. by James et al., CC BY 4.0PLOS ONE Successful contact tracing systems for COVID-19 rely on effective quarantine and isolation
Models of contact tracing often over-simplify the effects of quarantine and isolation on disease transmission. We develop a model that…
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Image creditFig 1. Data extraction and processing. by Tortolero et al., CC BY 4.0PLOS ONE Leveraging a health information exchange for analyses of COVID-19 outcomes including an example application using smoking history and mortality
Understanding sociodemographic, behavioral, clinical, and laboratory risk factors in patients diagnosed with COVID-19 is critically…