Medicine & Health

Dementia: Across the Lifespan & Around the Globe

Published January 3, 2019 Curated Collections

Alzheimer’s Disease International (ADI) estimates there will be over 131.5 million people living with dementia by 2050, as well as a shift in burden from the richest to poorest countries. These trends emphasize the need for a greater understanding of dementia from a global perspective. This PLOS Medicine Special Issue, guest edited by Carol Brayne and Bruce Miller, includes research articles, editorials, and perspectives that highlight the broad range of dementia research.

Image Credit: dierk schaefer, Flickr

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Guest Editors
PLOS Medicine Special Issue
Additional Content
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Guest Editors

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Carol Brayne

PLOS Medicine Dr. Carol Brayne
November 11, 2016 Guest Editor, PLOS Medicine Dementia Special Issue
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Bruce Miller

PLOS Medicine Dr. Bruce L. Miller
November 11, 2016 Guest Editor, PLOS Medicine Dementia Special Issue

PLOS Medicine Special Issue

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PublicDomainPictures, Pixabay

PLOS Medicine Dementia and aging populations—A global priority for contextualized research and health policy
March 28, 2017 Carol Brayne, Bruce Miller
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sarcifilippo, Pixabay

PLOS Medicine The impact of individual Cognitive Stimulation Therapy (iCST) on cognition, quality of life, caregiver health, and family relationships in dementia: A randomised controlled trial
March 28, 2017 Martin Orrell, Lauren Yates, Phuong Leung, Sujin Kang, Zoe Hoare, Chris Whitaker, Alistair Burns, Martin Knapp, Iracema Leroi, Esme Moniz-Cook, Stephen Pearson, Stephen Simpson, Aimee Spector, Steven Roberts, Ian Russell, Hugo de Waal, Robert Woods, Vasiliki Orgeta
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parentingupstream. Pixabay

PLOS Medicine Association between delirium superimposed on dementia and mortality in hospitalized older adults: A prospective cohort study
March 28, 2017 Thiago Avelino-Silva, Flavia Campora, Jose Curiati, Wilson Jacob-Filho
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NIH, Wikipedia

PLOS Medicine APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases
March 28, 2017 Hélène-Marie Lanoiselée, Gaël Nicolas, David Wallon, Anne Rovelet-Lecrux, Morgane Lacour, Stéphane Rousseau, Anne-Claire Richard, Muriel Quillard-Muraine, Florence Pasquier, Adeline Rollin-Sillaire, Olivier Martinaud, Vincent de la Sayette, Claire Boutoleau-Bretonniere, Frédérique Etcharry-Bouyx, Valérie Chauviré, Marie Sarazin, Isabelle le Ber, Stéphane Epelbaum, Thérèse Jonveaux, Olivier Rouaud, Mathieu Ceccaldi, Olivier Félician, Olivier Godefroy, Maite Formaglio, Bernard Croisile, Sophie Auriacombe, Ludivine Chamard, Jean-Louis Vincent, Mathilde Sauvée, Cecilia Marelli-Tosi, Audrey Gabelle, Canan Ozsancak, Jérémie Pariente, Claire Paquet, Didier Hannequin, Dominique Campion
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wyi, Flickr

PLOS Medicine Differential associations of plasma lipids with incident dementia and dementia subtypes in the 3C Study: A longitudinal, population-based prospective cohort study
March 28, 2017 Sabrina Schilling, Christophe Tzourio, Aïcha Soumaré, Sara Kaffashian, Jean-François Dartigues, Marie-Laure Ancelin, Cécilia Samiéri, Carole Dufouil, Stéphanie Debette
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mujitra, Flickr

PLOS Medicine Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case–control study
March 28, 2017 Natasha Steele, Jessie Carr, Luke Bonham, Ethan Geier, Vincent Damotte, Zachary Miller, Rahul Desikan, Kevin Boehme, Shubhabrata Mukherjee, Paul Crane, John Kauwe, Joel Kramer, Bruce Miller, Giovanni Coppola, Jill Hollenbach, Yadong Huang, Jennifer Yokoyama
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DigitalRalph, Flickr

PLOS Medicine Neuropathological diagnoses and clinical correlates in older adults in Brazil: A cross-sectional study
March 28, 2017 Claudia Suemoto, Renata Ferretti-Rebustini, Roberta Rodriguez, Renata Leite, Luciana Soterio, Sonia Brucki, Raphael Spera, Tarsila Cippiciani, Jose Farfel, Alexandre Chiavegatto Filho, Michel Naslavsky, Mayana Zatz, Carlos Pasqualucci, Wilson Jacob-Filho, Ricardo Nitrini, Lea Grinberg
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CDC Global, Flickr

PLOS Medicine Dementia in low-income and middle-income countries: Different realities mandate tailored solutions
March 28, 2017 Cleusa Ferri, K.S. Jacob
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geralt, Pixabay

PLOS Medicine Cultural representations of dementia
March 28, 2017 Alexandra Hillman, Joanna Latimer
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geralt, Pixabay

PLOS Medicine Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
March 21, 2017 Rahul Desikan, Chun Fan, Yunpeng Wang, Andrew Schork, Howard Cabral, L. Cupples, Wesley Thompson, Lilah Besser, Walter Kukull, Dominic Holland, Chi-Hua Chen, James Brewer, David Karow, karolina kauppi, aree witeolar, celeste karch, Luke Bonham, Jennifer Yokoyama, Howard Rosen, Bruce Miller, William Dillon, David Wilson, Christopher Hess, Margaret Pericak-Vance, Jonathan Haines, Lindsay Farrer, Richard Mayeux, John Hardy, Alison Goate, Bradley hyman, gerard Schellenberg, Linda McEvoy, Ole Andreassen, Anders Dale
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hey__paul, Flickr

PLOS Medicine Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study
March 21, 2017 Stuart Snowden, Amera Ebshiana, Abdul Hye, Yang An, Olga Pletnikova, Richard O'Brien, John Troncoso, Madhav Thambisetty, Cristina Legido-Quigley
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nwispeare, Flickr

PLOS Medicine Potentially modifiable lifestyle factors, cognitive reserve, and cognitive function in later life: A cross-sectional study
March 21, 2017 Linda Clare, Yu-Tzu Wu, Julia Teale, Catherine MacLeod, Fiona Matthews, Carol Brayne, Bob Woods
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unsplash, Pixabay

PLOS Medicine Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethno-cultural groups and geographic regions: a collaborative cohort study
March 21, 2017 Darren Lipnicki, John Crawford, Rajib Dutta, Anbupalam Thalamuthu, Nicole Kochan, Gavin Andrews, M. Fernanda Lima-Costa, Erico Castro-Costa, Carol Brayne, Fiona Matthews, Blossom Stephan, Richard Lipton, Mindy Katz, Karen Ritchie, Jacqueline Scali, Marie-Laure Ancelin, Nikolaos Scarmeas, Mary Yannakoulia, Efthimios Dardiotis, Linda Lam, Candy Wong, Ada Fung, Antonio Guaita, Roberta Vaccaro, Annalisa Davin, Ki Woong Kim, Ji Won Han, Tae Hui Kim, Kaarin Anstey, Nicolas Cherbuin, Peter Butterworth, Marcia Scazufca, Shuzo Kumagai, Sanmei Chen, Kenji Narazaki, Tze Pin Ng, Qi Gao, Simone Reppermund, Henry Brodaty, Antonio Lobo, Raul Lopez-Anton, Javier Santabarbara, Perminder Sachdev
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geralt, Pixabay

PLOS Medicine APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts
March 21, 2017 Jing Qian, Frank Wolters, Alexa Beiser, Mary Haan, M. Ikram, Jason Karlawish, Jessica Langbaum, John Neuhaus, Eric Reiman, J. Roberts, Sudha Seshadri, Pierre Tariot, Beth Woods, Rebecca Betensky, Deborah Blacker
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Tyler Merbler, Flickr

PLOS Medicine Development of an adaptive, personalized, and scalable dementia care program: Early findings from the Care Ecosystem
March 21, 2017 Katherine Possin, Jennifer Merrilees, Stephen Bonasera, Alissa Bernstein, Winston Chiong, Kirby Lee, Leslie Wilson, Sarah Hooper, Sarah Dulaney, Tamara Braley, Sutep Laohavanich, Julie Feuer, Amy Clark, Michael Schaffer, A. Katrin Schenk, Julia Heunis, Paulina Ong, Kristen Cook, Angela Bowhay, Rosalie Gearhart, Anna Chodos, Georges Naasan, Andrew Bindman, Daniel Dohan, Christine Ritchie, Bruce Miller
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maxlkt, Pixabay

PLOS Medicine Dementia in the oldest old: Beyond Alzheimer disease
March 21, 2017 Aimee Pierce, Claudia Kawas
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FotoEmotions, Pixabay

PLOS Medicine Effectiveness of an intervention to facilitate prompt referral to memory clinics in the United Kingdom: Cluster randomised controlled trial
March 14, 2017 Gill Livingston, Gianluca Baio, Andrew Sommerlad, Simon de Lusignan, Spyridon Poulimenos, Steve Morris, Greta Rait, Juanita Hoe
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qmnomic, Flickr

PLOS Medicine Association of lifelong exposure to cognitive reserve-enhancing factors with dementia risk: A community-based cohort study
March 14, 2017 Huixin Wang, Stuart Macdonald, Serhiy Dekhtyar, Laura Fratiglioni
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hermaion, Pixabay

PLOS Medicine Early diagnosis of mild cognitive impairment and mild dementia through basic and instrumental activities of daily living: Development of a new evaluation tool
March 14, 2017 Elise Cornelis, Ellen Gorus, Ingo Beyer, Ivan Bautmans, Patricia De Vriendt
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sasint, Pixabay

PLOS Medicine Challenges and opportunities in the diagnosis and management of older people with dementia in acute hospitals: Understanding delirium and dementia
March 14, 2017 Thomas Jackson, John Gladman, Rowan Harwood, Alasdair MacLullich, Elizabeth Sampson, Bart Sheehan, Daniel Davis
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PublicDomainPictures, Pixabay

PLOS Medicine Mixed pathologies and neural reserve: Implications of complexity for Alzheimer disease drug discovery
March 14, 2017 David Bennett
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unsplash, Pixabay

PLOS Medicine Subjective and objective cognitive function among older adults with a history of traumatic brain injury: A population-based cohort study
March 7, 2017 Raquel Gardner, Kenneth Langa, Kristine Yaffe
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foooomio, Flickr

PLOS Medicine Dementia incidence trend over 1992-2014 in the Netherlands: analysis of primary care data
March 7, 2017 Emma van Bussel, Edo Richard, Derk Arts, Astrid Nooyens, Preciosa Coloma, Margot de Waal, Marjan van den Akker, Marion Biermans, Markus Nielen, Kees van Boven, Hugo Smeets, Fiona Matthews, Carol Brayne, Wim Busschers, Willem van Gool, Eric Moll van Charante
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maxklt, Pixabay

PLOS Medicine Multimorbidity and healthcare utilization among home care clients with dementia in Ontario, Canada: A retrospective analysis of a population-based cohort
March 7, 2017 Luke Mondor, Colleen Maxwell, David Hogan, Susan Bronskill, Andrea Gruneir, Natasha Lane, Walter Wodchis
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geralt, Pixabay

PLOS Medicine What’s the “Take Home” from Research on Dementia Trends?
March 7, 2017 Eric Larson, Kenneth Langa
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Chris Marchant, Flickr

PLOS Medicine Rehabilitation for people living with dementia: A practical framework of positive support
March 7, 2017 Linda Clare

Additional Content

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dierk schaefer, Flickr

Speaking of Medicine A PLOS Medicine Special Issue: Dementia across the lifespan and around the globe
March 14, 2017 Associate Editor Tom McBride discusses the contents of the Dementia Special Issue’s first two weeks.
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Eric May, Flickr

Speaking of Medicine PLOS Medicine Podcast: Dementia Across the Lifespan and Around the Globe
September 21, 2016 PLOS Medicine Associate Editor Tom McBride interviews the Guest Editors for our Special Issue on Dementia.