The risk of progression of low-grade (CIN1) to high-grade cervical intraepithelial neoplasia (CIN2/3) is 3–5 times higher for women living…
Medicine & Health
Early Detection, Screening and Diagnosis of Cancer
Early diagnosis of cancer is vital for ensuring patients have the best chance of survival. When diagnosed early, more treatment options are available, they can be more effective and survival rates improve. By implementing effective screening strategies, cancer can be detected and diagnosed earlier; however, progress in cancer screening and detection is impacted by developments in diagnosis methods, identification of novel biomarkers, and cost-benefit considerations of screening implementation, amongst other factors.
In this collection, we showcase a selection of recently published study protocols and research articles exploring development of novel methods and biomarkers, along with challenges around screening uptake and diagnosis.
Image Credit: Retro black clock by Diloka Studios, Freepik
PLOS ONE
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PLOS ONE Comparative Assessment of p16/Ki-67 Dual Staining Technology for cervical cancer screening in women living with HIV (COMPASS-DUST)–Study protocol
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PLOS ONE “What do I think about implementing lung cancer screening? It all depends on how.” Acceptability and feasibility of lung cancer screening in Australia: The view of key stakeholders about health system factors
Background: Lung cancer is the number one cause of cancer death worldwide. Although international trials demonstrate that targeted…
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PLOS ONE Leveraging COVID-era innovation for cervical cancer screening: Clinician awareness and attitudes toward self-sampling and rapid testing for HPV detection
Cervical cancer screening rates are declining in the US, with persistent disparities among vulnerable populations. Strategies to better…
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PLOS ONE Invitation methods for Indigenous New Zealand Māori in lung cancer screening: Protocol for a pragmatic cluster randomized controlled trial
Lung cancer screening can significantly reduce mortality from lung cancer. Further evidence about how to optimize lung cancer screening…
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PLOS ONE Te Ara Waiora–Implementing human papillomavirus (HPV) primary testing to prevent cervical cancer in Aotearoa New Zealand: A protocol for a non-inferiority trial
Background: Cervical cancer is caused by high-risk types of human papillomavirus (HPV). Testing for high-risk HPV is a more sensitive…
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PLOS ONE Cancer prevention in cancer predisposition syndromes: A protocol for testing the feasibility of building a hereditary cancer research registry and nurse navigator follow up model
Monogenic, high penetrance syndromes, conferring an increased risk of malignancies in multiple organs, are important contributors to the…
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PLOS ONE Detection of malignancy in whole slide images of endometrial cancer biopsies using artificial intelligence
In this study we use artificial intelligence (AI) to categorise endometrial biopsy whole slide images (WSI) from digital pathology as…
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PLOS ONE Tumor-infiltrating lymphocytes and macrophages as a significant prognostic factor in biliary tract cancer
Background: The impact of tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) on the prognosis of biliary tract…
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PLOS ONE CELA3B immunostaining is a highly specific marker for acinar cell carcinoma of the pancreas
Chymotrypsin-like elastase family member 3B (CELA3B, elastase-3B) is a pancreatic enzyme with digestive function in the intestine. Since…
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PLOS ONE Serum proteomic profiling reveals MTA2 and AGO2 as potential prognostic biomarkers associated with disease activity and adverse outcomes in multiple myeloma
Multiple myeloma (MM) is an incurable plasma cell malignancy accounting for approximately 10% of hematological malignancies.…
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PLOS ONE Biomarker expression and survival in patients with non-small cell lung cancer receiving adjuvant chemotherapy in Denmark
Introduction: Programmed cell death ligand-1 (PD-L1) expression may help identify patients with non-small cell lung cancer (NSCLC) who…
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PLOS ONE A scoping review protocol on diagnostic strategies to detect occult malignancies in individuals with ischemic stroke
Background: Emerging data show an increased risk of ischemic stroke in patients with a new diagnosis of cancer. As the risk of stroke…
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PLOS ONE Association between cancer stigma and cervical cancer screening uptake among women of Dhulikhel and Banepa, Nepal
Background: Cervical cancer ranks as the most common cancer among Nepalese women with a high incidence and mortality. Despite evidence that…
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PLOS ONE Early signs of cancer present in the fine detail of mammograms
The gist of abnormality can be rapidly extracted by medical experts from global information in medical images, such as mammograms, to…
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PLOS ONE Flexible transition probability model for assessing cost-effectiveness of breast cancer screening extension to include women aged 45-49 and 70-74
Breast cancer is the most common cancer among Western women. Fortunately, organized screening has reduced breast cancer mortality. New…
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PLOS ONE Genetic variants of MUC4 are associated with susceptibility to and mortality of colorectal cancer and exhibit synergistic effects with LDL-C levels
As a disease with high mortality and prevalence rates worldwide, colorectal cancer (CRC) has been thoroughly investigated. Mucins are…
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PLOS ONE Impact of COVID-19 on older adults with cancer and their caregivers’ cancer treatment experiences study: The ICE-OLD study
The COVID-19 pandemic and health services impacts related to physical distancing posed many challenges for older adults with cancer. The…
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PLOS ONE Women’s views about current and future management of Ductal Carcinoma in Situ (DCIS): A mixed-methods study
Management of low-risk ductal carcinoma in situ (DCIS) is controversial, with clinical trials currently assessing the safety of active…