Biology & Life Sciences

Epigenetics 2010

Published May 24, 2018 Partnered Collections, Special Issues

Epigenetics is the study of inherited changes in phenotype or gene expression caused by mechanisms other than changes in the underlying DNA sequence. This collection brings together twenty research articles published in five PLOS journals in the area of epigenetics during 2010, along with a Research in Translation article and two Primers. They reflect a range of model systems and organisms, and variously offer phenotypic, mechanistic, and chromatin-based insights.

Image Credit: Sánchez MB, Martínez JL (2012)

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Primers
Research in Translation
Research Articles

Primers

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10.1371/journal.pbio.1000318

PLOS Biology Genomic Responses to Abnormal Gene Dosage: The X Chromosome Improved on a Common Strategy
February 23, 2010 Xinxian Deng, Christine M. Disteche
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10.1371/journal.pbio.1000326

PLOS Biology Centromeres Convert but Don’t Cross
March 9, 2010 Paul B. Talbert, Steven Henikoff

Research in Translation

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10.1371/journal.pmed.1000356

PLOS Medicine Epigenetic Epidemiology of Common Complex Disease: Prospects for Prediction, Prevention, and Treatment
October 26, 2010 Caroline L. Relton, George Davey Smith

Research Articles

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10.1371/journal.pbio.1000332

PLOS Biology Spatial Epigenetic Control of Mono- and Bistable Gene Expression
March 16, 2010 János Z. Kelemen, Prasuna Ratna, Simone Scherrer, Attila Becskei
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10.1371/journal.pbio.1000327

PLOS Biology Widespread Gene Conversion in Centromere Cores
March 9, 2010 Jinghua Shi, Sarah E. Wolf, John M. Burke, Gernot G. Presting, Jeffrey Ross-Ibarra, R. Kelly Dawe
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10.1371/journal.pbio.1000320

PLOS Biology Expression in Aneuploid Drosophila S2 Cells
February 23, 2010 Yu Zhang, John H. Malone, Sara K. Powell, Vipul Periwal, Eric Spana, David M. MacAlpine, Brian Oliver
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10.1371/journal.pbio.1000276

PLOS Biology 2-D Structure of the A Region of Xist RNA and Its Implication for PRC2 Association
January 5, 2010 Sylvain Maenner, Magali Blaud, Laetitia Fouillen, Anne Savoye, Virginie Marchand, Agnès Dubois, Sarah Sanglier-Cianférani, Alain Van Dorsselaer, Philippe Clerc, Philip Avner, Athanase Visvikis, Christiane Branlant
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10.1371/journal.pbio.1000270

PLOS Biology Poised Transcription Factories Prime Silent uPA Gene Prior to Activation
January 5, 2010 Carmelo Ferrai, Sheila Q. Xie, Paolo Luraghi, Davide Munari, Francisco Ramirez, Miguel R. Branco, Ana Pombo, Massimo P. Crippa
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10.1371/journal.pcbi.1000849

PLOS Computational Biology Computational Analysis of Whole-Genome Differential Allelic Expression Data in Human
July 8, 2010 James R. Wagner, Bing Ge, Dmitry Pokholok, Kevin L. Gunderson, Tomi Pastinen, Mathieu Blanchette
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10.1371/journal.pgen.1001142

PLOS Genetics Altering a Histone H3K4 Methylation Pathway in Glomerular Podocytes Promotes a Chronic Disease Phenotype
October 28, 2010 Gaelle M. Lefevre, Sanjeevkumar R. Patel, Doyeob Kim, Lino Tessarollo, Gregory R. Dressler
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10.1371/journal.pgen.1000992

PLOS Genetics The IG-DMR and the MEG3-DMR at Human Chromosome 14q32.2: Hierarchical Interaction and Distinct Functional Properties as Imprinting Control Centers
June 17, 2010 Masayo Kagami, Maureen J. O'Sullivan, Andrew J. Green, Yoshiyuki Watabe, Osamu Arisaka, Nobuhide Masawa, Kentarou Matsuoka, Maki Fukami, Keiko Matsubara, Fumiko Kato, Anne C. Ferguson-Smith, Tsutomu Ogata
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10.1371/journal.pgen.1000986

PLOS Genetics siRNA–Mediated Methylation of Arabidopsis Telomeres
June 10, 2010 Jan Vrbsky, Svetlana Akimcheva, J. Matthew Watson, Thomas L. Turner, Lucia Daxinger, Boris Vyskot, Werner Aufsatz, Karel Riha
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10.1371/journal.pgen.1000889

PLOS Genetics Initial Genomics of the Human Nucleolus
March 26, 2010 Attila Németh, Ana Conesa, Javier Santoyo-Lopez, Ignacio Medina, David Montaner, Bálint Péterfia, Irina Solovei, Thomas Cremer, Joaquin Dopazo, Gernot Längst
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10.1371/journal.pgen.1000846

PLOS Genetics Nuclear Pore Proteins Nup153 and Megator Define Transcriptionally Active Regions in the Drosophila Genome
February 12, 2010 Juan M. Vaquerizas, Ritsuko Suyama, Jop Kind, Kota Miura, Nicholas M. Luscombe, Asifa Akhtar
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10.1371/journal.pgen.1000811

PLOS Genetics Maternal Ethanol Consumption Alters the Epigenotype and the Phenotype of Offspring in a Mouse Model
January 15, 2010 Nina Kaminen-Ahola, Arttu Ahola, Murat Maga, Kylie-Ann Mallitt, Paul Fahey, Timothy C. Cox, Emma Whitelaw, Suyinn Chong
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10.1371/journal.ppat.1001013

PLOS Pathogens Epigenetic Analysis of KSHV Latent and Lytic Genomes
July 22, 2010 Zsolt Toth, Dennis T. Maglinte, Sun Hwa Lee, Hye-Ra Lee, Lai-Yee Wong, Kevin F. Brulois, Stacy Lee, Jonathan D. Buckley, Peter W. Laird, Victor E. Marquez, Jae U. Jung
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10.1371/journal.ppat.1000935

PLOS Pathogens The Epigenetic Landscape of Latent Kaposi Sarcoma-Associated Herpesvirus Genomes
June 3, 2010 Thomas Günther, Adam Grundhoff
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10.1371/journal.ppat.1000775

PLOS Pathogens A New Nuclear Function of the Entamoeba histolytica Glycolytic Enzyme Enolase: The Metabolic Regulation of Cytosine-5 Methyltransferase 2 (Dnmt2) Activity
February 19, 2010 Ayala Tovy, Rama Siman Tov, Ricarda Gaentzsch, Mark Helm, Serge Ankri
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10.1371/journal.pone.0010326

PLOS ONE Epigenetic Variation in Mangrove Plants Occurring in Contrasting Natural Environment
April 26, 2010 Catarina Fonseca Lira-Medeiros, Christian Parisod, Ricardo Avancini Fernandes, Camila Souza Mata, Monica Aires Cardoso, Paulo Cavalcanti Gomes Ferreira
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10.1371/journal.pone.0009749

PLOS ONE Hepatocellular Carcinoma Displays Distinct DNA Methylation Signatures with Potential as Clinical Predictors
March 17, 2010 Hector Hernandez-Vargas, Marie-Pierre Lambert, Florence Le Calvez-Kelm, Géraldine Gouysse, Sandrine McKay-Chopin, Sean V. Tavtigian, Jean-Yves Scoazec, Zdenko Herceg
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10.1371/journal.pone.0009320

PLOS ONE Whole Methylome Analysis by Ultra-Deep Sequencing Using Two-Base Encoding
February 22, 2010 Christina A. Bormann Chung, Victoria L. Boyd, Kevin J. McKernan, Yutao Fu, Cinna Monighetti, Heather E. Peckham, Melissa Barker
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10.1371/journal.pone.0008697

PLOS ONE Role for DNA Methylation in the Regulation of miR-200c and miR-141 Expression in Normal and Cancer Cells
January 13, 2010 Lukas Vrba, Taylor J. Jensen, James C. Garbe, Ronald L. Heimark, Anne E. Cress, Sally Dickinson, Martha R. Stampfer, Bernard W. Futscher
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10.1371/journal.pone.0008564

PLOS ONE Differential DNA Methylation Correlates with Differential Expression of Angiogenic Factors in Human Heart Failure
January 13, 2010 Mehregan Movassagh, Mun-Kit Choy, Martin Goddard, Martin R. Bennett, Thomas A. Down, Roger S.-Y. Foo