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Medicine & Health

Flubendazole in Onchocerciasis

Partnered Collections, Special Issues

Treating onchocerciasis remains a challenge as no drug effectively kills the adult worms. A new orally bioavailable formulation of flubendazole was developed and tested to find out whether it could be a safe and effective macrofilaricidal drug. The introduction to this collection explains the history and rationale for development. The subsequent 3 articles report on the efficacy, PK and safety as observed in animal models. The last article summarizes the toxicology and preclinical PK data generated with this new flubendazole formulation. It also explains that the decision to discontinue its development was taken because no safe and effective dose could be selected for use in clinical trials.

Image Credit: International Centre for Eye Health, London School of Hygiene & Tropical Medicine.

Preclinical efficacy of flubendazole in antifilarial animal models
Preclinical toxicology and pharmacokinetics of a new oral flubendazole formulation
PLOS Biologue


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