Biology & Life Sciences

Immunobiology

Published October 17, 2016 Curated Collections

Immunobiology is the study of the components that make up the body's immune system, how these arise during embryogenesis and function together, and how they evolve in different organisms in response to pathogens and the environment encountered. This collection collates some of the best and most recent immunobiology articles published at PLOS, featuring papers that examine cellular and molecular immunology, evolutionary immunology, animal models of the human immune system and ontogeny of the immune system. The biology featured in this collection serves to complement the studies in the Clinical Immunology Collection that highlight immune-related challenges faced by individuals and the health care profession.

Image Credit: National Cancer Institute (NCI) / Creator: Don Bliss, Sriram Subramaniam / PLOS

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Research

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10.1371/journal.ppat.1005501

PLOS Pathogens The Lymphocytic Choriomeningitis Virus Matrix Protein PPXY Late Domain Drives the Production of Defective Interfering Particles
March 24, 2016 Christopher M. Ziegler, Philip Eisenhauer, Emily A. Bruce, Marion E. Weir, Benjamin R. King, Joseph P. Klaus, Dimitry N. Krementsov, David J. Shirley, Bryan A. Ballif, Jason Botten
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10.1371/journal.pgen.1005645

PLOS Genetics DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation
November 6, 2015 Jana Prochazkova, Shinya Sakaguchi, Michel Owusu, Abdelghani Mazouzi, Marc Wiedner, Georgia Velimezi, Martin Moder, Gleb Turchinovich, Anastasiya Hladik, Elisabeth Gurnhofer, Adrian Hayday, Axel Behrens, Sylvia Knapp, Lukas Kenner, Wilfried Ellmeier, Joanna I. Loizou
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10.1371/journal.ppat.1005177

PLOS Pathogens CD39 Expression Identifies Terminally Exhausted CD8⁺ T Cells
October 20, 2015 Prakash K. Gupta, Jernej Godec, David Wolski, Emily Adland, Kathleen Yates, Kristen E. Pauken, Cormac Cosgrove, Carola Ledderose, Wolfgang G. Junger, Simon C. Robson, E. John Wherry, Galit Alter, Philip J. R. Goulder, Paul Klenerman, Arlene H. Sharpe, Georg M. Lauer, W. Nicholas Haining
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10.1371/journal.ppat.1005210

PLOS Pathogens Perivascular Arrest of CD8⁺ T Cells Is a Signature of Experimental Cerebral Malaria
November 12, 2015 Tovah N. Shaw, Phillip J. Stewart-Hutchinson, Patrick Strangward, Durga B. Dandamudi, Jonathan A. Coles, Ana Villegas-Mendez, Julio Gallego-Delgado, Nico van Rooijen, Egor Zindy, Ana Rodriguez, James M. Brewer, Kevin N. Couper, Michael L. Dustin
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10.1371/journal.pbio.1000407

PLOS Biology Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells
June 29, 2010 Marielle C. Gold, Stefania Cerri, Susan Smyk-Pearson, Meghan E. Cansler, Todd M. Vogt, Jacob Delepine, Ervina Winata, Gwendolyn M. Swarbrick, Wei-Jen Chua, Yik Y. L. Yu, Olivier Lantz, Matthew S. Cook, Megan D. Null, David B. Jacoby, Melanie J. Harriff, Deborah A. Lewinsohn, Ted H. Hansen, David M. Lewinsohn
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10.1371/journal.pbio.1000562

PLOS Biology Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Parallels between Tumor Initiation and Wound Inflammation
December 14, 2010 Yi Feng, Cristina Santoriello, Marina Mione, Adam Hurlstone, Paul Martin
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10.1371/journal.pcbi.1002267

PLOS Computational Biology Dynamical and Structural Analysis of a T Cell Survival Network Identifies Novel Candidate Therapeutic Targets for Large Granular Lymphocyte Leukemia
November 10, 2011 Assieh Saadatpour, Rui-Sheng Wang, Aijun Liao, Xin Liu, Thomas Loughran, Istvan Albert, Reka Albert
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10.1371/journal.pone.0030264

PLOS ONE Membrane-Bound IL-21 Promotes Sustained Ex Vivo Proliferation of Human Natural Killer Cells
January 18, 2012 Cecele Denman, Vladimir Senyukov, Srinivas Somanchi, Prasad Phatarpekar, Lisa Kopp, Jennifer Johnson, Harjeet Singh, Lenka Hurton, Sourindra Maiti, M Huls, Richard Champlin, Laurence Cooper, Dean Lee
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10.1371/journal.pone.0029979

PLOS ONE Expression Profiling of Human Immune Cell Subsets Identifies miRNA-mRNA Regulatory Relationships Correlated with Cell Type Specific Expression
January 20, 2012 Florence Allantaz, Donavan Cheng, Tobias Bergauer, Palanikumar Ravindran, Michel Rossier, Martin Ebeling, Laura Badi, Bernhard Reis, Hans Bitter, Matilde D'Asaro, Alberto Chiappe, Sriram Sridhar, Gonzalo Duran Pacheco, Michael Burczynski, Denis Hochstrasser, Jacky Vonderscher, Thomas Matthes
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10.1371/journal.ppat.1002506

PLOS Pathogens Absence of HIV-1 Evolution in the Gut-Associated Lymphoid Tissue from Patients on Combination Antiviral Therapy Initiated during Primary Infection
February 2, 2012 Teresa Evering, Saurabh Mehandru, Paul Racz, Klara Tenner-Racz, Michael Poles, Amir Figueroa, Hiroshi Mohri, Martin Markowitz
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10.1371/journal.pone.0030832

PLOS ONE MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State
February 17, 2012 Reuben Saba, Shantel Gushue, Rhiannon Huzarewich, Kathy Manguiat, Sarah Medina, Catherine Robertson, Stephanie Booth
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10.1371/journal.pone.0032777

PLOS ONE Evolution of JAK-STAT Pathway Components: Mechanisms and Role in Immune System Development
March 7, 2012 Clifford Liongue, Lynda O’Sullivan, Monique Trengove, Alister Ward
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10.1371/journal.pone.0032084

PLOS ONE Dextran Sodium Sulfate (DSS) Induces Colitis in Mice by Forming Nano-Lipocomplexes with Medium-Chain-Length Fatty Acids in the Colon
March 9, 2012 Hamed Laroui, Sarah Ingersoll, Hong Chun Liu, Mark Baker, Saravanan Ayyadurai, Famina Laroui, Moiz Charania, Yutao Yan, Shanthi Sitaraman, Didier Merlin
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10.1371/journal.ppat.1002594

PLOS Pathogens TGF-β1 Down-Regulation of NKG2D/DAP10 and 2B4/SAP Expression on Human NK Cells Contributes to HBV Persistence
March 15, 2012 Cheng Sun, Binqing Fu, Yufeng Gao, Xiaofeng Liao, Rui Sun, Zhigang Tian, Haiming Wei
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10.1371/journal.ppat.1002638

PLOS Pathogens Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome
March 29, 2012 Jonathan Levinsohn, Zachary Newman, Kristina Hellmich, Rasem Fattah, Matthew Getz, Shihui Liu, Inka Sastalla, Stephen Leppla, Mahtab Moayeri
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10.1371/journal.ppat.1002605

PLOS Pathogens A Novel Mouse Model of Schistosoma haematobium Egg-Induced Immunopathology
March 29, 2012 Chi-Ling Fu, Justin Odegaard, De'Broski Herbert, Michael Hsieh
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10.1371/journal.pone.0034547

PLOS ONE Phenotypic and Functional Properties of Helios⁺ Regulatory T Cells
March 30, 2012 Daniel Zabransky, Christopher Nirschl, Nicholas Durham, Ben Park, Christina Ceccato, Tullia Bruno, Ada Tam, Derese Getnet, Charles Drake
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10.1371/journal.ppat.1002730

PLOS Pathogens Evolution of an Eurasian Avian-like Influenza Virus in Naïve and Vaccinated Pigs
May 31, 2012 Pablo Murcia, Joseph Hughes, Patrizia Battista, Lucy Lloyd, Gregory Baillie, Ricardo Ramirez-Gonzalez, Doug Ormond, Karen Oliver, Debra Elton, Jennifer Mumford, Mario Caccamo, Paul Kellam, Bryan Grenfell, Edward Holmes, James Wood
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10.1371/journal.pbio.1001368

PLOS Biology The Evolutionary Consequences of Blood-Stage Vaccination on the Rodent Malaria Plasmodium chabaudi
July 31, 2012 Victoria Barclay, Derek Sim, Brian Chan, Lucas Nell, Maia Rabaa, Andrew Bell, Robin Anders, Andrew Read
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10.1371/journal.ppat.1002714

PLOS Pathogens Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon
May 31, 2012 Seong Jeon, Hisako Kayama, Yoshiyasu Ueda, Takuya Takahashi, Takashi Asahara, Hirokazu Tsuji, Noriko Tsuji, Hiroshi Kiyono, Ji Ma, Takashi Kusu, Ryu Okumura, Hiromitsu Hara, Hiroki Yoshida, Masahiro Yamamoto, Koji Nomoto, Kiyoshi Takeda
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10.1371/journal.pone.0051657

PLOS ONE The Evolution and Origin of Animal Toll-Like Receptor Signaling Pathway Revealed by Network-Level Molecular Evolutionary Analyses
December 7, 2012 Xiaojun Song, Ping Jin, Sheng Qin, Liming Chen, Fei Ma
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10.1371/journal.pcbi.1002840

PLOS Computational Biology The Two Sides of Complement C3d: Evolution of Electrostatics in a Link between Innate and Adaptive Immunity
December 27, 2012 Chris Kieslich, Dimitrios Morikis
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10.1371/journal.ppat.1003118

PLOS Pathogens IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling
January 3, 2013 Helen Lazear, Alissa Lancaster, Courtney Wilkins, Mehul Suthar, Albert Huang, Sarah Vick, Lisa Clepper, Larissa Thackray, Margaret Brassil, Herbert Virgin, Janko Nikolich-Zugich, Ashlee Moses, Michael Gale, Jr, Klaus Fruh, Michael Diamond
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10.1371/journal.ppat.1003135

PLOS Pathogens Convergence and Divergence in the Evolution of the APOBEC3G-Vif Interaction Reveal Ancient Origins of Simian Immunodeficiency Viruses
January 24, 2013 Alex Compton, Michael Emerman
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10.1371/journal.ppat.1003264

PLOS Pathogens Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis Vaccine
April 4, 2013 Padraig Ross, Caroline Sutton, Sarah Higgins, Aideen Allen, Kevin Walsh, Alicja Misiak, Ed Lavelle, Rachel McLoughlin, Kingston Mills
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10.1371/journal.pbio.1001566

PLOS Biology Elimination of Self-Reactive T Cells in the Thymus: A Timeline for Negative Selection
May 21, 2013 Ivan Dzhagalov, Katherine Chen, Paul Herzmark, Ellen Robey
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10.1371/journal.pbio.1001633

PLOS Biology Stable T-bet⁺GATA-3⁺ Th1/Th2 Hybrid Cells Arise In Vivo, Can Develop Directly from Naive Precursors, and Limit Immunopathologic Inflammation
August 20, 2013 Michael Peine, Sebastian Rausch, Caroline Helmstetter, Anja Fröhlich, Ahmed Hegazy, Anja Kühl, Christoph Grevelding, Thomas Höfer, Susanne Hartmann, Max Löhning
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10.1371/journal.pbio.1001618

PLOS Biology Stochastic Cytokine Expression Induces Mixed T Helper Cell States
July 30, 2013 Miaoqing Fang, Huangming Xie, Stephanie Dougan, Hidde Ploegh, Alexander van Oudenaarden
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10.1371/journal.pbio.1001674

PLOS Biology TGF-β Signalling Is Required for CD4⁺ T Cell Homeostasis But Dispensable for Regulatory T Cell Function
October 8, 2013 Anna Śledzińska, Saskia Hemmers, Florian Mair, Oliver Gorka, Jürgen Ruland, Lynsey Fairbairn, Anja Nissler, Werner Müller, Ari Waisman, Burkhard Becher, Thorsten Buch
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10.1371/journal.pbio.1001692

PLOS Biology Fitness Trade-offs Restrict the Evolution of Resistance to Amphotericin B
October 29, 2013 Benjamin Vincent, Alex Lancaster, Ruth Scherz-Shouval, Luke Whitesell, Susan Lindquist
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10.1371/journal.pbio.1001704

PLOS Biology N-WASP Is Essential for the Negative Regulation of B Cell Receptor Signaling
November 5, 2013 Chaohong Liu, Xiaoming Bai, Junfeng Wu, Shruti Sharma, Arpita Upadhyaya, Carin Dahlberg, Lisa Westerberg, Scott Snapper, Xiaodong Zhao, Wenxia Song
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10.1371/journal.ppat.1003766

PLOS Pathogens Natural Selection Promotes Antigenic Evolvability
November 14, 2013 Christopher Graves, Vera Ros, Brian Stevenson, Paul Sniegowski, Dustin Brisson
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10.1371/journal.pbio.1001759

PLOS Biology Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation
January 7, 2014 Austin Pantel, Angela Teixeira, Elias Haddad, Elizabeth Wood, Ralph Steinman, M Paula Longhi
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10.1371/journal.pbio.1001793

PLOS Biology Cecum Lymph Node Dendritic Cells Harbor Slow-Growing Bacteria Phenotypically Tolerant to Antibiotic Treatment
February 18, 2014 Patrick Kaiser, Roland Regoes, Tamas Dolowschiak, Sandra Wotzka, Jette Lengefeld, Emma Slack, Andrew Grant, Martin Ackermann, Wolf-Dietrich Hardt
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10.1371/journal.ppat.1004264

PLOS Pathogens A Novel Mouse Model of Campylobacter jejuni Gastroenteritis Reveals Key Pro-inflammatory and Tissue Protective Roles for Toll-like Receptor Signaling during Infection
July 17, 2014 Martin Stahl, Jenna Ries, Jenny Vermeulen, Hong Yang, Ho Pan Sham, Shauna Crowley, Yuliya Badayeva, Stuart Turvey, Erin Gaynor, Xiaoxia Li, Bruce Vallance

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