Medicine & Health

Combating NTDs: Lessons from India

Published June 8, 2016 Curated Collections

In this collection PLOS NTDs highlights the contributions of Indian authors, labs, and institutions to the global fight against neglected tropical diseases. It includes over 40 primary research articles reporting significant advances in the fields of epidemiology, diagnosis, treatment, vaccine development and applications, and vector control.

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Vector Control
Vaccine Development and Applications
Treatment
Diagnosis
Epidemiology

Vector Control

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10.1371/journal.pntd.0002990

PLOS Neglected Tropical Diseases Evidence of Experimental Vertical Transmission of Emerging Novel ECSA Genotype of Chikungunya Virus in Aedes aegypti
July 31, 2014 Ankita Agarwal, Paban Kumar Dash, Anil Kumar Singh, Shashi Sharma, Natarajan Gopalan, Putcha Venkata Lakshmana Rao, Man Mohan Parida, Paul Reiter
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10.1371/journal.pntd.0001296

PLOS Neglected Tropical Diseases Serological Markers of Sand Fly Exposure to Evaluate Insecticidal Nets against Visceral Leishmaniasis in India and Nepal: A Cluster-Randomized Trial
September 13, 2011 Kamlesh Gidwani, Albert Picado, Suman Rijal, Shri Prakash Singh, Lalita Roy, Vera Volfova, Elisabeth Wreford Andersen, Surendra Uranw, Bart Ostyn, Medhavi Sudarshan, Jaya Chakravarty, Petr Volf, Shyam Sundar, Marleen Boelaert, Matthew Edward Rogers
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Shrinet et al.

PLOS Neglected Tropical Diseases Next Generation Sequencing Reveals Regulation of Distinct Aedes microRNAs during Chikungunya Virus Development
January 9, 2014 Jatin Shrinet, Shanu Jain, Jaspreet Jain, Raj K. Bhatnagar, Sujatha Sunil
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Ghosh et al.

PLOS Neglected Tropical Diseases The Jacob2 Lectin of the Entamoeba histolytica Cyst Wall Binds Chitin and Is Polymorphic
July 20, 2010 Sudip K. Ghosh, Katrina L. Van Dellen, Anirban Chatterjee, Tuli Dey, Rashidul Haque, Phillips W. Robbins, John Samuelson
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10.1371/journal.pntd.0003332

PLOS Neglected Tropical Diseases Pyrethroid-Resistance and Presence of Two Knockdown Resistance (kdr) Mutations, F1534C and a Novel Mutation T1520I, in Indian Aedes aegypti
January 8, 2015 Raja Babu S. Kushwah, Cherry L. Dykes, Neera Kapoor, Tridibes Adak, Om P. Singh
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Muhammad Mahdi Karim

PLOS Neglected Tropical Diseases Community-Effectiveness of Temephos for Dengue Vector Control: A Systematic Literature Review
September 15, 2015 Leyanna George, Audrey Lenhart, Joao Toledo, Adhara Lazaro, Wai Wai Han, Raman Velayudhan, Silvia Runge Ranzinger, Olaf Horstick

Vaccine Development and Applications

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10.1371/journal.pntd.0002762

PLOS Neglected Tropical Diseases Expansion of Parasite-Specific CD4⁺ and CD8⁺ T Cells Expressing IL-10 Superfamily Cytokine Members and Their Regulation in Human Lymphatic Filariasis
April 3, 2014 Rajamanickam Anuradha, Parakkal Jovvian George, Luke E. Hanna, Paul Kumaran, Vedachalam Chandrasekaran, Thomas B. Nutman, Subash Babu
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10.1371/journal.pntd.0002737

PLOS Neglected Tropical Diseases Serologic Prevalence of Toxoplasma gondii in Indian Women of Child Bearing Age and Effects of Social and Environmental Factors
March 27, 2014 Sarman Singh, Arshi Munawwar, Sugandhi Rao, Sanjay Mehta, Naba Kumar Hazarika
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10.1371/journal.pntd.0003198

PLOS Neglected Tropical Diseases Leishmania Specific CD4 T Cells Release IFNγ That Limits Parasite Replication in Patients with Visceral Leishmaniasis
October 2, 2014 Rajiv Kumar, Neetu Singh, Shalini Gautam, Om Prakash Singh, Kamlesh Gidwani, Madhukar Rai, David Sacks, Shyam Sundar, Susanne Nylén
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10.1371/journal.pntd.0002629

PLOS Neglected Tropical Diseases Mass Vaccination with a New, Less Expensive Oral Cholera Vaccine Using Public Health Infrastructure in India: The Odisha Model
February 6, 2014 Shantanu K. Kar, Bikash Patnaik, Yang Hee Kim, Anna S. Kerketta, Sunheang Shin, Shyam Bandhu Rath, Mohammad Ali, Vittal Mogasale, Hemant K. Khuntia, Anuj Bhattachan, Young Ae You, Mahesh K. Puri, Anna Lena Lopez, Brian Maskery, Gopinath B. Nair, John D. Clemens, Thomas F. Wierzba, Binod Sah
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Sur et al.

PLOS Neglected Tropical Diseases Efficacy of a Low-Cost, Inactivated Whole-Cell Oral Cholera Vaccine: Results from 3 Years of Follow-Up of a Randomized, Controlled Trial
October 18, 2011 Dipika Sur, Suman Kanungo, Binod Sah, Byomkesh Manna, Mohammad Ali, Allison M. Paisley, Swapan K. Niyogi, Jin Kyung Park, Banawarilal Sarkar, Mahesh K. Puri, Deok Ryun Kim, Jacqueline L. Deen, Jan Holmgren, Rodney Carbis, Raman Rao, Nguyen Thu Van, Seung Hyun Han, Stephen Attridge, Allan Donner, Nirmal K. Ganguly, Sujit K. Bhattacharya, G. Balakrish Nair, John D. Clemens, Anna Lena Lopez
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10.1371/journal.pntd.0001735

PLOS Neglected Tropical Diseases Adenovirus Delivered Short Hairpin RNA Targeting a Conserved Site in the 5′ Non-Translated Region Inhibits All Four Serotypes of Dengue Viruses
July 24, 2012 Anil Babu Korrapati, Gokul Swaminathan, Aarti Singh, Navin Khanna, Sathyamangalam Swaminathan
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Guha et al.

PLOS Neglected Tropical Diseases Antimony Resistant Leishmania donovani but Not Sensitive Ones Drives Greater Frequency of Potent T-Regulatory Cells upon Interaction with Human PBMCs: Role of IL-10 and TGF-β in Early Immune Response
July 17, 2014 Rajan Guha, Shantanabha Das, June Ghosh, Shyam Sundar, Jean Claude Dujardin, Syamal Roy
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10.1371/journal.pntd.0003574

PLOS Neglected Tropical Diseases Flexibility of Oral Cholera Vaccine Dosing—A Randomized Controlled Trial Measuring Immune Responses Following Alternative Vaccination Schedules in a Cholera Hyper-Endemic Zone
March 12, 2015 Suman Kanungo, Sachin N. Desai, Ranjan Kumar Nandy, Mihir Kumar Bhattacharya, Deok Ryun Kim, Anuradha Sinha, Tanmay Mahapatra, Jae Seung Yang, Anna Lena Lopez, Byomkesh Manna, Barnali Bannerjee, Mohammad Ali, Mandeep Singh Dhingra, Ananga Mohan Chandra, John D. Clemens, Dipika Sur, Thomas F. Wierzba
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10.1371/journal.pntd.0003809

PLOS Neglected Tropical Diseases An Open Label Non-inferiority Trial Assessing Vibriocidal Response of a Killed Bivalent Oral Cholera Vaccine Regimen following a Five Year Interval in Kolkata, India
May 29, 2015 Suman Kanungo, Sachin N. Desai, Jayanta Saha, Ranjan Kumar Nandy, Anuradha Sinha, Deok Ryun Kim, Barnali Bannerjee, Byomkesh Manna, Jae Seung Yang, Mohammad Ali, Dipika Sur, Thomas F. Wierzba

Treatment

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Bhattacharya et al.

PLOS Neglected Tropical Diseases Viper and Cobra Venom Neutralization by Alginate Coated Multicomponent Polyvalent Antivenom Administered by the Oral Route
August 7, 2014 Sourav Bhattacharya, Mousumi Chakraborty, Piyasi Mukhopadhyay, P. P. Kundu, Roshnara Mishra
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10.1371/journal.pntd.0002536

PLOS Neglected Tropical Diseases Risk Factors for Visceral Leishmaniasis Relapse in Immunocompetent Patients following Treatment with 20 mg/kg Liposomal Amphotericin B (Ambisome) in Bihar, India
January 2, 2014 Sakib Burza, Prabhat K. Sinha, Raman Mahajan, María Angeles Lima, Gaurab Mitra, Neena Verma, Manica Balsegaram, Pradeep Das
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10.1371/journal.pntd.0003169

PLOS Neglected Tropical Diseases Efficacy and Safety of Amphotericin B Emulsion versus Liposomal Formulation in Indian Patients with Visceral Leishmaniasis: A Randomized, Open-Label Study
September 18, 2014 Shyam Sundar, Chandreshwar Prasad Thakur, Tara Kant Jha, Vidya Nand Ravi Das, Neena Verma, Chandra Shekhar Lal, Deepak Verma, Shahnawaz Alam, Pradeep Das, Krishna Pandey
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10.1371/journal.pntd.0001657

PLOS Neglected Tropical Diseases Drug Susceptibility in Leishmania Isolates Following Miltefosine Treatment in Cases of Visceral Leishmaniasis and Post Kala-Azar Dermal Leishmaniasis
May 22, 2012 Vasundhra Bhandari, Arpita Kulshrestha, Deepak Kumar Deep, Olivia Stark, Vijay Kumar Prajapati, V. Ramesh, Shyam Sundar, Gabriele Schonian, Jean Claude Dujardin, Poonam Salotra
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10.1371/journal.pntd.0002611

PLOS Neglected Tropical Diseases Post Kala-Azar Dermal Leishmaniasis following Treatment with 20 mg/kg Liposomal Amphotericin B (Ambisome) for Primary Visceral Leishmaniasis in Bihar, India
January 2, 2014 Sakib Burza, Prabhat Kumar Sinha, Raman Mahajan, Marta González Sanz, María Angeles Lima, Gaurab Mitra, Neena Verma, Pradeep Das
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10.1371/journal.pntd.0003053

PLOS Neglected Tropical Diseases Visceral Leishmaniasis and HIV Co-infection in Bihar, India: Long-term Effectiveness and Treatment Outcomes with Liposomal Amphotericin B (AmBisome)
August 7, 2014 Sakib Burza, Raman Mahajan, Prabhat K. Sinha, Johan van Griensven, Krishna Pandey, María Angeles Lima, Marta Gonzalez Sanz, Temmy Sunyoto, Sunil Kumar, Gaurab Mitra, Ranjeet Kumar, Neena Verma, Pradeep Das
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10.1371/journal.pntd.0004093

PLOS Neglected Tropical Diseases Decline in Clinical Efficacy of Oral Miltefosine in Treatment of Post Kala-azar Dermal Leishmaniasis (PKDL) in India
October 22, 2015 V. Ramesh, Ruchi Singh, Kumar Avishek, Aditya Verma, Deepak Kumar Deep, Sandeep Verma, Poonam Salotra

Diagnosis

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10.1371/journal.pntd.0001653

PLOS Neglected Tropical Diseases Detection, Isolation and Confirmation of Crimean-Congo Hemorrhagic Fever Virus in Human, Ticks and Animals in Ahmadabad, India, 2010–2011
May 15, 2012 Devendra T. Mourya, Pragya D. Yadav, Anita M. Shete, Yogesh K. Gurav, Chandrashekhar G. Raut, Ramesh S. Jadi, Shailesh D. Pawar, Stuart T. Nichol, Akhilesh C. Mishra
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Sharma et al.

PLOS Neglected Tropical Diseases Molecular Characterization of Echinococcus granulosus Cysts in North Indian Patients: Identification of G1, G3, G5 and G6 Genotypes
June 13, 2013 Monika Sharma, Rakesh Sehgal, Bashir Ahmad Fomda, Anil Malhotra, Nancy Malla
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10.1371/journal.pntd.0001673

PLOS Neglected Tropical Diseases Sporotrichosis in Sub-Himalayan India
June 12, 2012 Santwana Verma, Ghanshyam K. Verma, Gagandeep Singh, Anil Kanga, Vinay Shanker, Digvijay Singh, Poonam Gupta, Kiran Mokta, Vinita Sharma
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Jain et al.

PLOS Neglected Tropical Diseases High-Resolution Sonography: A New Technique to Detect Nerve Damage in Leprosy
August 11, 2009 Suman Jain, Leo H. Visser, T. L. N. Praveen, P. Narasimha Rao, Thummalakunta Surekha, Ramesh Ellanti, Thummalakunta L. N. Abhishek, Indira Nath
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10.1371/journal.pntd.0003366

PLOS Neglected Tropical Diseases Quantitative PCR in Epidemiology for Early Detection of Visceral Leishmaniasis Cases in India
December 11, 2014 Medhavi Sudarshan, Toolika Singh, Abhishek Kumar Singh, Ankita Chourasia, Bhawana Singh, Mary E. Wilson, Jaya Chakravarty, Shyam Sundar

Epidemiology

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10.1371/journal.pntd.0001222

PLOS Neglected Tropical Diseases The Neglected Tropical Diseases of India and South Asia: Review of Their Prevalence, Distribution, and Control or Elimination
October 25, 2011 Derek A. Lobo, Raman Velayudhan, Priya Chatterjee, Harajeshwar Kohli, Peter J. Hotez
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Mohapatra et al.

PLOS Neglected Tropical Diseases Snakebite Mortality in India: A Nationally Representative Mortality Survey
April 12, 2011 Bijayeeni Mohapatra, David A. Warrell, Wilson Suraweera, Prakash Bhatia, Neeraj Dhingra, Raju M. Jotkar, Peter S. Rodriguez, Kaushik Mishra, Romulus Whitaker, for the Million Death Study Collaborators , Prabhat Jha
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Awasthi et al.

PLOS Neglected Tropical Diseases Effects of Deworming on Malnourished Preschool Children in India: An Open-Labelled, Cluster-Randomized Trial
April 16, 2008 Shally Awasthi, Richard Peto, Vinod K. Pande, Robert H. Fletcher, Simon Read, Donald A. P. Bundy
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10.1371/journal.pntd.0000579

PLOS Neglected Tropical Diseases Increasing Trends of Leptospirosis in Northern India: A Clinico-Epidemiological Study
January 12, 2010 Sunil Sethi, Navneet Sharma, Nandita Kakkar, Juhi Taneja, Shiv Sekhar Chatterjee, Surinder Singh Banga, Meera Sharma
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10.1371/journal.pntd.0001748

PLOS Neglected Tropical Diseases Moving from Rabies Research to Rabies Control: Lessons from India
August 7, 2012 Manish Kakkar, Vidya Venkataramanan, Sampath Krishnan, Ritu Singh Chauhan, Syed Shahid Abbas, on behalf of Roadmap to Combat Zoonoses in India (RCZI) initiative
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10.1371/journal.pntd.0001405

PLOS Neglected Tropical Diseases Visceral Leishmaniasis in the Indian Subcontinent: Modelling Epidemiology and Control
November 29, 2011 Anette Stauch, Ram Rup Sarkar, Albert Picado, Bart Ostyn, Shyam Sundar, Suman Rijal, Marleen Boelaert, Jean-Claude Dujardin, Hans-Peter Duerr
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10.1371/journal.pntd.0000355

PLOS Neglected Tropical Diseases Visceral Leishmaniasis Elimination Programme in India, Bangladesh, and Nepal: Reshaping the Case Finding/Case Management Strategy
January 13, 2009 Dinesh Mondal, Shri Prakash Singh, Narendra Kumar, Anand Joshi, Shyam Sundar, Pradeep Das, Hirve Siddhivinayak, Axel Kroeger, Marleen Boelaert
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10.1371/journal.pntd.0002721

PLOS Neglected Tropical Diseases Costs Analysis of a Population Level Rabies Control Programme in Tamil Nadu, India
February 27, 2014 Syed Shahid Abbas, Manish Kakkar, Elizabeth Tacket Rogawski, on behalf of the Roadmap to Combat Zoonoses in India (RCZI) initiative
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10.1371/journal.pntd.0001926

PLOS Neglected Tropical Diseases Epidemiological Assessment of Eight Rounds of Mass Drug Administration for Lymphatic Filariasis in India: Implications for Monitoring and Evaluation
November 29, 2012 Subramanian Swaminathan, Vanamail Perumal, Srividya Adinarayanan, Krishnamoorthy Kaliannagounder, Ravi Rengachari, Jambulingam Purushothaman
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10.1371/journal.pntd.0002603

PLOS Neglected Tropical Diseases Five-Year Field Results and Long-Term Effectiveness of 20 mg/kg Liposomal Amphotericin B (Ambisome) for Visceral Leishmaniasis in Bihar, India
January 2, 2014 Sakib Burza, Prabhat K. Sinha, Raman Mahajan, María Angeles Lima, Gaurab Mitra, Neena Verma, Manica Balasegarem, Pradeep Das
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10.1371/journal.pntd.0002605

PLOS Neglected Tropical Diseases Scrub Typhus Is an Under-recognized Cause of Acute Febrile Illness with Acute Kidney Injury in India
January 30, 2014 Vivek Kumar, Vinod Kumar, Ashok K. Yadav, Sreenivasa Iyengar, Ashish Bhalla, Navneet Sharma, Ritesh Aggarwal, Sanjay Jain, Vivekanand Jha
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CDC

PLOS Neglected Tropical Diseases Population Migration: Implications for Lymphatic Filariasis Elimination Programmes
March 28, 2013 K. D. Ramaiah
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10.1371/journal.pntd.0000960

PLOS Neglected Tropical Diseases Options for Active Case Detection of Visceral Leishmaniasis in Endemic Districts of India, Nepal and Bangladesh, Comparing Yield, Feasibility and Costs
February 8, 2011 Shri Prakash Singh, Siddhivinayak Hirve, M. Mamun Huda, Megha Raj Banjara, Narendra Kumar, Dinesh Mondal, Shyam Sundar, Pradeep Das, Chitra Kumar Gurung, Suman Rijal, C. P. Thakur, Beena Varghese, Axel Kroeger
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10.1371/journal.pntd.0003020

PLOS Neglected Tropical Diseases How Far Are We from Visceral Leishmaniasis Elimination in Bangladesh? An Assessment of Epidemiological Surveillance Data
August 21, 2014 Rajib Chowdhury, Dinesh Mondal, Vashkar Chowdhury, Shyla Faria, Jorge Alvar, Shah Golam Nabi, Marleen Boelaert, Aditya Prasad Dash
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10.1371/journal.pntd.0003042

PLOS Neglected Tropical Diseases Burden of Diarrhea, Hospitalization and Mortality Due to Cryptosporidial Infections in Indian Children
July 24, 2014 Rajiv Sarkar, Jacqueline E. Tate, Sitara S. R. Ajjampur, Deepthi Kattula, Jacob John, Honorine D. Ward, Gagandeep Kang
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10.1371/journal.pntd.0003955

PLOS Neglected Tropical Diseases Maternal Infection Is a Risk Factor for Early Childhood Infection in Filariasis
July 30, 2015 Madhusmita Bal, Prakash K. Sahu, Nityananda Mandal, Ashok K. Satapathy, Manoranjan Ranjit, Shatanu K. Kar
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10.1371/journal.pntd.0004225

PLOS Neglected Tropical Diseases Molecular Epidemiology of Amoebiasis: A Cross-Sectional Study among North East Indian Population
December 3, 2015 Joyobrato Nath, Sankar Kumar Ghosh, Baby Singha, Jaishree Paul