Medicine & Health

Influenza

Published July 2, 2021 Calls for Papers Collections

Influenza is an important cause of death and morbidity globally. While vaccination is the best way to prevent influenza virus infection, other pharmaceutical and non-pharmaceutical strategies can prevent or mitigate the impact of influenza on individuals and the spread within populations. Influenza viruses are continually evolving, posing challenges to vaccination strategies and vaccine development.

In this PLOS ONE collection, our expert guest editors have compiled a selection of research articles that focus on influenza prevention on every level.

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Guest Editors
PLOS ONE Collection

Basic Science
Diagnostics
Epidemiology and Surveillance
Immunology
Vaccine Effectiveness
Vaccine Uptake

Guest Editors

Guest Editor, PLOS ONE Deshayne Fell
July 3, 2021
Guest Editor, PLOS ONE Meagan Deming
July 3, 2021

PLOS ONE Collection

Basic Science

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10.1371/journal.pone.0272332 CC BY 4.0

PLOS ONE Influenza vaccination of school teachers: A scoping review and an impact estimation
August 11, 2022 Anne Huiberts, Brigitte van Cleef, Aimée Tjon-A-Tsien, Frederika Dijkstra, Imke Schreuder, Ewout Fanoy, Arianne van Gageldonk, Wim van der Hoek, Liselotte van Asten

Introduction: Influenza vaccination, besides protecting traditional risk groups, can protect employees and reduce illness-related absence,…
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10.1371/journal.pone.0276099 CC BY 4.0

PLOS ONE Comparing the cobas Influenza A/B Nucleic acid test for use on the cobas Liat System (Liat) with rapid antigen tests for clinical management of Japanese patients at the point of care
October 27, 2022 Hiroshige Mikamo, Yusuke Koizumi, Yuka Yamagishi, Nobuhiro Asai, Yuko Miyazono, Toshikazu Shinbo, Michiko Horie, Kenichi Togashi, Elissa M. Robbins, Nobuo Hirotsu

Background: Rapid diagnosis of influenza is critical in preventing the spread of infection and ensuring patients quickly receive antiviral…
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10.1371/journal.pone.0253022 CC BY 4.0

PLOS ONE Ozone inactivation of airborne influenza and lack of resistance of respiratory syncytial virus to aerosolization and sampling processes
July 12, 2021 Marie-Eve Dubuis, Étienne Racine, Jonathan M. Vyskocil, Nathalie Turgeon, Christophe Tremblay, Espérance Mukawera, Guy Boivin, Nathalie Grandvaux, Caroline Duchaine

Influenza and RSV are human viruses responsible for outbreaks in hospitals, long-term care facilities and nursing homes. The present study…
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10.1371/journal.pone.0252170 CC BY 4.0

PLOS ONE Epitope-targeting platform for broadly protective influenza vaccines
May 27, 2021 David F. Zeigler, Emily Gage, Christopher H. Clegg

Seasonal influenza vaccines are often ineffective because they elicit strain-specific antibody responses to mutation-prone sites on the…
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10.1371/journal.pone.0239112 CC BY 4.0

PLOS ONE iBRAB: In silico based-designed broad-spectrum Fab against H1N1 influenza A virus
December 31, 2020 Phuc-Chau Do, Trung H. Nguyen, Uyen H. M. Vo, Ly Le

Influenza virus A is a significant agent involved in the outbreak of worldwide epidemics, causing millions of fatalities around the world…
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10.1371/journal.pone.0255282 CC BY 4.0

PLOS ONE Cellular responses at the application site of a high-density microarray patch delivering an influenza vaccine in a randomized, controlled phase I clinical trial
July 30, 2021 Alexandra C. I. Depelsenaire, Katey Witham, Margaret Veitch, James W. Wells, Christopher D. Anderson, Jason D. Lickliter, Steve Rockman, Jesse Bodle, Peter Treasure, Julian Hickling, Germain J. P. Fernando, Angus H. Forster

Microarray patches (MAPs) have the potential to be a safer, more acceptable, easier to use and more cost-effective method for…

Diagnostics

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10.1371/journal.pone.0268279 CC BY 4.0

PLOS ONE Assessment of potential factors associated with the sensitivity and specificity of Sofia Influenza A+B Fluorescent Immunoassay in an ambulatory care setting
May 10, 2022 Cristalyne Bell, Maureen Goss, Jennifer Birstler, Emily Temte, Guanhua Chen, Peter Shult, Erik Reisdorf, Thomas Haupt, Shari Barlow, Jonathan Temte

Background: Seasonal influenza leads to an increase in outpatient clinic visits. Timely, accurate, and affordable testing could facilitate…
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10.1371/journal.pone.0258482 CC BY 4.0

PLOS ONE Differentiating severe and non-severe lower respiratory tract illness in patients hospitalized with influenza: Development of the Influenza Disease Evaluation and Assessment of Severity (IDEAS) scale
October 21, 2021 Eric J. Chow, Mark W. Tenforde, Melissa A. Rolfes, Benjamin Lee, Shreya Chodisetty, Julio A. Ramirez, Alicia M. Fry, Manish M. Patel

Background: Experimental studies have shown that vaccination can reduce viral replication to attenuate progression of influenza-associated…
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10.1371/journal.pone.0247429 CC BY 4.0

PLOS ONE Avidin-biotin complex-based capture coating platform for universal Influenza virus immobilization and characterization
February 26, 2021 Micaela Trexler, Michelle Brusatori, Gregory Auner

Influenza virus mutates quickly and unpredictably creating emerging pathogenic strains that are difficult to detect, diagnose, and…

Epidemiology and Surveillance

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10.1371/journal.pone.0267111 CC BY 4.0

PLOS ONE Cause-specific student absenteeism monitoring in K-12 schools for detection of increased influenza activity in the surrounding community—Dane County, Wisconsin, 2014–2020
April 19, 2022 Jonathan L. Temte, Shari Barlow, Maureen Goss, Emily Temte, Amber Schemmel, Cristalyne Bell, Erik Reisdorf, Peter Shult, Mary Wedig, Thomas Haupt, James H. Conway, Ronald Gangnon, Amra Uzicanin

Background: Schools are primary venues of influenza amplification with secondary spread to communities. We assessed K-12 student…
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A rendition of the flu virus by quapan, CC BY 2.0

PLOS ONE Seasonal influenza during the COVID-19 pandemic in Bangladesh
August 3, 2021 Zubair Akhtar, Fahmida Chowdhury, Mahmudur Rahman, Probir Kumar Ghosh, Md. Kaousar Ahmmed, Md Ariful Islam, Joshua A. Mott, William Davis

Introduction: During the 2019 novel coronavirus infectious disease (COVID-19) pandemic in 2020, limited data from several countries…
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Fig 1. Weekly proportion of negative respiratory virus PCR test results (upper graph), weekly number of COVID-19 patients (middle graph), and weekly number of respiratory virus PCR tests (lower graph) in South Korea between the 1st week of 2015 and the 42nd week of 2020. by Kim et al., CC BY 4.0

PLOS ONE Impact of social distancing on the spread of common respiratory viruses during the coronavirus disease outbreak
June 14, 2021 Min-Chul Kim, Oh Joo Kweon, Yong Kwan Lim, Seong-Ho Choi, Jin-Won Chung, Mi-Kyung Lee

During the coronavirus disease (COVID-19) pandemic, social distancing was effective in controlling disease spread across South Korea. The…
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10.1371/journal.pone.0244346 CC BY 4.0

PLOS ONE The association between socioeconomic status and pandemic influenza: Systematic review and meta-analysis
September 7, 2021 Svenn-Erik Mamelund, Clare Shelley-Egan, Ole Rogeberg

Background: The objective of this study is to document whether and to what extent there is an association between socioeconomic status…
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10.1371/journal.pone.0253451 CC BY 4.0

PLOS ONE Respiratory virus surveillance in Canada during the COVID-19 pandemic: An epidemiological analysis of the effectiveness of pandemic-related public health measures in reducing seasonal respiratory viruses test positivity
June 18, 2021 Kyu Young Park, Sumin Seo, Junhee Han, Ji Young Park

Background: Various public health measures have been implemented globally to counter the coronavirus disease 2019 (COVID-19) pandemic. The…

Immunology

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10.1371/journal.pone.0253028 CC BY 4.0

PLOS ONE Antibody responses induced by trivalent inactivated influenza vaccine among pregnant and non-pregnant women in Thailand: A matched cohort study
June 9, 2021 Sutthichai Nakphook, Jayanton Patumanond, Manash Shrestha, Kriengkrai Prasert, Malinee Chittaganpitch, Joshua A. Mott, Prabda Praphasiri

Background: We compared influenza antibody titers among vaccinated and unvaccinated pregnant and non-pregnant women. Methods: During 1st…
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10.1371/journal.pone.0256475 CC BY 4.0

PLOS ONE Prevalence of antibodies against seasonal influenza A and B viruses among older adults in rural Thailand: A cross-sectional study
August 30, 2021 Nungruthai Suntronwong, Preeyaporn Vichaiwattana, Lakkhana Wongsrisang, Sirapa Klinfueng, Sumeth Korkong, Thanunrat Thongmee, Nasamon Wanlapakorn, Yong Poovorawan

Assessing the seroprevalence of the high-risk individuals against the influenza virus is essential to evaluate the progress of vaccine…
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10.1371/journal.pone.0254421 CC BY 4.0

PLOS ONE Impaired memory B-cell recall responses in the elderly following recurrent influenza vaccination
August 5, 2021 Rodrigo B. Abreu, Greg A. Kirchenbaum, Giuseppe A. Sautto, Emily F. Clutter, Ted M. Ross

Influenza is a highly contagious viral respiratory disease that affects million of people worldwide each year. Annual vaccination is…

Vaccine Effectiveness

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10.1371/journal.pone.0262072 CC BY 4.0

PLOS ONE Influenza vaccine in chronic obstructive pulmonary disease among elderly male veterans
January 4, 2022 Yinong Young-Xu, Jeremy Smith, Joshua Nealon, Salaheddin M. Mahmud, Robertus Van Aalst, Edward W. Thommes, Nabin Neupane, Jason K. H. Lee, Ayman Chit

Background: Prior studies have established those elderly patients with chronic obstructive pulmonary disease (COPD) are at elevated risk…
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Syringe and Vaccine by NIH/NIAID, CC BY 2.0

PLOS ONE Using Point of Care Testing to estimate influenza vaccine effectiveness in the English primary care sentinel surveillance network
March 11, 2021 Simon de Lusignan, Uy Hoang, Harshana Liyanage, Manasa Tripathy, Julian Sherlock, Mark Joy, Filipa Ferreira, Javier Diez-Domingo, Tristan Clark

Introduction: Rapid Point of Care Testing (POCT) for influenza could be used to provide information on influenza vaccine effectiveness…

Vaccine Uptake

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Influenza vaccine by u_7je6tzfl9s, Pixabay licenseCC BY 2.0

PLOS ONE Views and experiences of maternal healthcare providers regarding influenza vaccine during pregnancy globally: A systematic review and qualitative evidence synthesis
February 10, 2022 Fatemah Alhendyani, Kate Jolly, Laura L. Jones

Background: The World Health Organization (WHO) recommends that pregnant women receive influenza vaccination; however, uptake of the…
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flu shot by LuAnn Hunt, CC BY 2.0

PLOS ONE Knowledge attitudes and practices toward seasonal influenza vaccine among pregnant women during the 2018/2019 influenza season in Tunisia
March 22, 2022 Sonia Dhaouadi, Ghassen Kharroubi, Amal Cherif, Ines Cherif, Hind Bouguerra, Leila Bouabid, Nourhene Najar, Adel Gharbi, Afif Ben Salah, Nissaf Bouafif ép Ben Alaya, Jihene Bettaieb

Background: The uptake and acceptance of the influenza vaccine (IV) among pregnant women remain unknown in Tunisia despite the increased…
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10.1371/journal.pone.0255495 CC BY 4.0

PLOS ONE Attitudes towards influenza, and COVID-19 vaccines during the COVID-19 pandemic among a representative sample of the Jewish Israeli population
February 11, 2022 Yasmin Maor, Shaked Caspi

Background: Vaccine hesitancy is increasing. We assessed attitudes toward influenza and COVID-19 vaccines and the relation between…
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10.1371/journal.pone.0258258 CC BY 4.0

PLOS ONE Knowledge, attitude and practice of influenza vaccination among Lebanese parents: A cross-sectional survey from a developing country
October 14, 2021 Ramia Zakhour, Hani Tamim, Farah Faytrouni, Joanne Khoury, Maha Makki, Lama Charafeddine

Background: A growing number of parents refuse vaccination due to concerns about side effects. Influenza vaccine is no exception and…
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10.1371/journal.pone.0260213 CC BY 4.0

PLOS ONE Influenza vaccination coverage among emergency department personnel is associated with perception of vaccination and side effects, vaccination availability on site and the COVID-19 pandemic
November 19, 2021 Anna-Maria Stöckeler, Philipp Schuster, Markus Zimmermann, Frank Hanses

Introduction: Influenza is a major concern in hospitals, including the emergency department (ED), mainly because of a high risk for ED…
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10.1371/journal.pone.0259640 CC BY 4.0

PLOS ONE Reasons for nonadherence to vaccination for influenza among older people in Brazil
November 8, 2021 Aldiane Gomes de Macedo Bacurau, Ana Paula Sayuri Sato, Priscila Maria Stolses Bergamo Francisco

This study aimed to estimate the prevalence of non-vaccination and the reasons for nonadherence to the influenza vaccine among older…
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10.1371/journal.pone.0252836 CC BY 4.0

PLOS ONE Factors driving choices between types and brands of influenza vaccines in general practice in Austria, Italy, Spain and the UK
June 15, 2021 Anke L. Stuurman, Sara Ciampini, Alfredo Vannacci, Antonino Bella, Caterina Rizzo, Cintia Muñoz-Quiles, Elisabetta Pandolfi, Harshana Liyanage, Mendel Haag, Monika Redlberger-Fritz, Roberto Bonaiuti, Philippe Beutels

Influenza vaccine effectiveness (IVE) assessment is increasingly stratified by vaccine type or brand, such as done by the European network…
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10.1371/journal.pone.0249785 CC BY 4.0

PLOS ONE Influenza vaccination uptake and factors influencing vaccination decision among patients with chronic kidney or liver disease
April 13, 2021 Michael Eder, Haris Omic, Jana Gorges, Florian Badt, Zeljko Kikic, Marcus D. Saemann, Allison Tong, David Bauer, Georg Semmler, Thomas Reiberger, Heimo Lagler, Bernhard Scheiner

Introduction: Seasonal influenza is a major global health problem causing substantial morbidity and health care costs. Yet, in many…
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10.1371/journal.pone.0252510 CC BY 4.0

PLOS ONE Accounting for the spread of vaccination behavior to optimize influenza vaccination programs
June 4, 2021 Dor Kahana, Dan Yamin

Vaccination is the most efficient means of preventing influenza infection and its complications. While previous studies have considered…

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