Biology & Life Sciences

Neurodegenerative Disease Research

Published November 13, 2017 Curated Collections

The Neurodegenerative Disease Research section of the PLOS Neuroscience Collection includes a selection of research articles published in PLOS journals since 2014. Neurodegenerative diseases are incurable and debilitating conditions that result from progressive degeneration and/or death of nerve cells and cause problems with movement or mental functioning. This section is divided into five subsections, including General Neurodegenerative Disease, Alzheimer’s disease, Parkinson’s disease, Multiple Sclerosis and Amyotrophic Lateral Sclerosis (ALS). PLOS welcomes submissions in these fields.

Image Credit: Alvin Gogineni, Genentech / NIH image gallery

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Neurodegenerative Disease Research
Alzheimer's Disease
Parkinson's Disease
Amyotrophic Lateral Sclerosis
Multiple Sclerosis

Neurodegenerative Disease Research

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10.1371/journal.pmed.1002287

PLOS Medicine Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data
April 25, 2017 Charles C. White, Hyun-Sik Yang, Lei Yu, Lori B. Chibnik, Robert J. Dawe, Jingyun Yang, Hans-Ulrich Klein, Daniel Felsky, Alfredo Ramos-Miguel, Konstantinos Arfanakis, William G. Honer, Reisa A. Sperling, Julie A. Schneider, David A. Bennett, Philip L. De Jager
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10.1371/journal.pgen.1006621

PLOS Genetics Active zone proteins are transported via distinct mechanisms regulated by Par-1 kinase
February 21, 2017 Kara R. Barber, Julia Tanquary, Keegan Bush, Amanda Shaw, Michael Woodson, Michael Sherman, Yogesh P. Wairkar
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10.1371/journal.pbio.1002579

PLOS Biology Distribution of Misfolded Prion Protein Seeding Activity Alone Does Not Predict Regions of Neurodegeneration
November 23, 2016 James Alibhai, Richard A. Blanco, Marcelo A. Barria, Pedro Piccardo, Byron Caughey, V. Hugh Perry, Tom C. Freeman, Jean C. Manson
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10.1371/journal.pbio.1002472

PLOS Biology NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies
June 2, 2016 Yousuf O. Ali, Hunter M. Allen, Lei Yu, David Li-Kroeger, Dena Bakhshizadehmahmoudi, Asante Hatcher, Cristin McCabe, Jishu Xu, Nicole Bjorklund, Giulio Taglialatela, David A. Bennett, Philip L. De Jager, Joshua M. Shulman, Hugo J. Bellen, Hui-Chen Lu
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10.1371/journal.pone.0138866

PLOS ONE Predicting Progression from Mild Cognitive Impairment to Alzheimer’s Dementia Using Clinical, MRI, and Plasma Biomarkers via Probabilistic Pattern Classification
February 22, 2016 Igor O. Korolev, Laura L. Symonds, Andrea C. Bozoki, Alzheimer's Disease Neuroimaging Initiative
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10.1371/journal.pone.0136271

PLOS ONE Understanding the Impact of Brain Disorders: Towards a ‘Horizontal Epidemiology’ of Psychosocial Difficulties and Their Determinants
September 7, 2015 Alarcos Cieza, Marta Anczewska, Jose Luis Ayuso-Mateos, Mary Baker, Jerome Bickenbach, Somnath Chatterji, Sally Hartley, Matilde Leonardi, Tuuli Pitkänen, PARADISE Consortium
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10.1371/journal.pbio.1002361

PLOS Biology Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation
January 26, 2016 Rubén Hervás, Liying Li, Amitabha Majumdar, María del Carmen Fernández-Ramírez, Jay R. Unruh, Brian D. Slaughter, Albert Galera-Prat, Elena Santana, Mari Suzuki, Yoshitaka Nagai, Marta Bruix, Sergio Casas-Tintó, Margarita Menéndez, Douglas V. Laurents, Kausik Si, Mariano Carrión-Vázquez
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10.1371/journal.pone.0143045

PLOS ONE An Effective Method to Identify Shared Pathways and Common Factors among Neurodegenerative Diseases
November 17, 2015 Ping Li, Yaling Nie, Jingkai Yu
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10.1371/journal.pone.0137342

PLOS ONE Comparative Incidence of Conformational, Neurodegenerative Disorders
September 3, 2015 Jesús de Pedro-Cuesta, Alberto Rábano, Pablo Martínez-Martín, María Ruiz-Tovar, Enrique Alcalde-Cabero, Javier Almazán-Isla, Fuencisla Avellanal, Miguel Calero
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10.1371/journal.pmed.1001756

PLOS Medicine Computerized Cognitive Training in Cognitively Healthy Older Adults: A Systematic Review and Meta-Analysis of Effect Modifiers
November 18, 2014 Amit Lampit, Harry Hallock, Michael Valenzuela
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10.1371/journal.pmed.1001756

PLOS Neuroscience Community Brain Games Not Quite Ready For Prime Time: A PLOS Medicine Meta-analysis Of Computerized Cognitive Training
December 23, 2014 Pierre Mégevand

Alzheimer's Disease

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10.1371/journal.pbio.2001336

PLOS Biology Human cyclophilin 40 unravels neurotoxic amyloids
June 27, 2017 Jeremy D. Baker, Lindsey B. Shelton, Dali Zheng, Filippo Favretto, Bryce A. Nordhues, April Darling, Leia E. Sullivan, Zheying Sun, Parth K. Solanki, Mackenzie D. Martin, Amirthaa Suntharalingam, Jonathan J. Sabbagh, Stefan Becker, Eckhard Mandelkow, Vladimir N. Uversky, Markus Zweckstetter, Chad A. Dickey, John Koren III, Laura J. Blair
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10.1371/journal.pgen.1006593

PLOS Genetics Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease
March 2, 2017 Fiona Kerr, Oyinkan Sofola-Adesakin, Dobril K. Ivanov, Jemma Gatliff, Beatriz Gomez Perez-Nievas, Hélène C. Bertrand, Pedro Martinez, Rebecca Callard, Inge Snoeren, Helena M. Cochemé, Jennifer Adcott, Mobina Khericha, Jorge Iván Castillo-Quan, Geoffrey Wells, Wendy Noble, Janet Thornton, Linda Partridge
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10.1371/journal.pone.0138866

PLOS ONE Predicting Progression from Mild Cognitive Impairment to Alzheimer’s Dementia Using Clinical, MRI, and Plasma Biomarkers via Probabilistic Pattern Classification
February 22, 2016 Igor O. Korolev, Laura L. Symonds, Andrea C. Bozoki, Alzheimer's Disease Neuroimaging Initiative
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10.1371/journal.pone.0138866

PLOS ECR Community Waving the red flag: The search for early markers of Alzheimer’s Disease
March 30, 2016 Ríona McArdle
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10.1371/journal.pone.0150441

PLOS ONE Synaptosomal Mitochondrial Dysfunction in 5xFAD Mouse Model of Alzheimer’s Disease
March 4, 2016 Lu Wang, Lan Guo, Lin Lu, Huili Sun, Muming Shao, Simon J. Beck, Lin Li, Janani Ramachandran, Yifeng Du, Heng Du
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10.1371/journal.pone.0148099

PLOS ONE High-Fat Diet Changes Hippocampal Apolipoprotein E (ApoE) in a Genotype- and Carbohydrate-Dependent Manner in Mice
February 1, 2016 Courtney Lane-Donovan, Joachim Herz
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10.1371/journal.pbio.1002279

PLOS Biology APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction
October 29, 2015 Ileana Soto, Leah C. Graham, Hannah J. Richter, Stephen N. Simeone, Jake E. Radell, Weronika Grabowska, W. Keith Funkhouser, Megan C. Howell, Gareth R. Howell
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10.1371/journal.pmed.1001841

PLOS Medicine Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study
June 16, 2015 Søren D. Østergaard, Shubhabrata Mukherjee, Stephen J. Sharp, Petroula Proitsi, Luca A. Lotta, Felix Day, John R. B. Perry, Kevin L. Boehme, Stefan Walter, John S. Kauwe, Laura E. Gibbons, Alzheimer’s Disease Genetics Consortium , The GERAD1 Consortium , EPIC-InterAct Consortium , Eric B. Larson, John F. Powell, Claudia Langenberg, Paul K. Crane, Nicholas J. Wareham, Robert A. Scott
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10.1371/journal.pcbi.1003956

PLOS Computational Biology Epidemic Spreading Model to Characterize Misfolded Proteins Propagation in Aging and Associated Neurodegenerative Disorders
November 20, 2014 Yasser Iturria-Medina, Roberto C. Sotero, Paule J. Toussaint, Alan C. Evans, and the Alzheimer's Disease Neuroimaging Initiative
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10.1371/journal.pone.0125614

PLOS ONE Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy Models
May 1, 2015 Sethu Sankaranarayanan, Donna M. Barten, Laurel Vana, Nino Devidze, Ling Yang, Gregory Cadelina, Nina Hoque, Lynn DeCarr, Stefanie Keenan, Alan Lin, Yang Cao, Bradley Snyder, Bin Zhang, Magdalena Nitla, Gregg Hirschfeld, Nestor Barrezueta, Craig Polson, Paul Wes, Vangipuram S. Rangan, Angela Cacace, Charles F. Albright, Jere Meredith Jr., John Q. Trojanowski, Virginia M-Y. Lee, Kurt R. Brunden, Michael Ahlijanian
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10.1371/journal.pone.0142340

PLOS ONE The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy
November 5, 2015 Robert Siman, Ryan Cocca, Yina Dong
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10.1371/journal.pmed.1001853

PLOS Medicine HHEX_23 AA Genotype Exacerbates Effect of Diabetes on Dementia and Alzheimer Disease: A Population-Based Longitudinal Study
July 14, 2015 Wei-Li Xu, Nancy L. Pedersen, Lina Keller, Grégoria Kalpouzos, Hui-Xin Wang, Caroline Graff, Bengt Winblad, Lars Bäckman, Laura Fratiglioni
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10.1371/journal.pmed.1001713

PLOS Medicine Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis
September 16, 2014 Petroula Proitsi, Michelle K. Lupton, Latha Velayudhan, Stephen Newhouse, Isabella Fogh, Magda Tsolaki, Makrina Daniilidou, Megan Pritchard, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Vellas, for the Alzheimer's Disease Neuroimaging Initiative , Julie Williams, for the GERAD1 Consortium , Robert Stewart, Pak Sham, Simon Lovestone, John F. Powell
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Tim Rittman

Speaking of Medicine The Alzheimer Disease International Conference 2016 – “Think Global, Act Local”
May 9, 2016 Timothy Rittman, Wienke Jacobsen, Clare Walton

Parkinson's Disease

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10.1371/journal.pone.0175674

PLOS ONE Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease
May 17, 2017 Chelsea Caspell-Garcia, Tanya Simuni, Duygu Tosun-Turgut, I-Wei Wu, Yu Zhang, Mike Nalls, Andrew Singleton, Leslie A. Shaw, Ju-Hee Kang, John Q. Trojanowski, Andrew Siderowf, Christopher Coffey, Shirley Lasch, Dag Aarsland, David Burn, Lana M. Chahine, Alberto J. Espay, Eric D. Foster, Keith A. Hawkins, Irene Litvan, Irene Richard, the Parkinson’s Progression Markers Initiative (PPMI) , Daniel Weintraub
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10.1371/journal.pbio.2000374

PLOS Biology The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
March 3, 2017 Rita Machado de Oliveira, Hugo Vicente Miranda, Laetitia Francelle, Raquel Pinho, Éva M. Szegö, Renato Martinho, Francesca Munari, Diana F. Lázaro, Sébastien Moniot, Patrícia Guerreiro, Luis Fonseca, Zrinka Marijanovic, Pedro Antas, Ellen Gerhardt, Francisco Javier Enguita, Bruno Fauvet, Deborah Penque, Teresa Faria Pais, Qiang Tong, Stefan Becker, Sebastian Kügler, Hilal Ahmed Lashuel, Clemens Steegborn, Markus Zweckstetter, Tiago Fleming Outeiro
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10.1371/journal.pone.0152716

PLOS ONE Cerebral Metabolic Differences Associated with Cognitive Impairment in Parkinson’s Disease
April 11, 2016 Yilin Tang, Jingjie Ge, Fengtao Liu, Ping Wu, Sisi Guo, Zhenyang Liu, Yixuan Wang, Ying Wang, Zhengtong Ding, Jianjun Wu, Chuantao Zuo, Jian Wang
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10.1371/journal.pmed.1001954

PLOS Medicine Risk of Injurious Fall and Hip Fracture up to 26 y before the Diagnosis of Parkinson Disease: Nested Case–Control Studies in a Nationwide Cohort
February 2, 2016 Helena Nyström, Anna Nordström, Peter Nordström
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10.1371/journal.pone.0124325

PLOS ONE Activin A Protects Midbrain Neurons in the 6-Hydroxydopamine Mouse Model of Parkinson’s Disease
April 22, 2015 Sandy Stayte, Peggy Rentsch, Kong M. Li, Bryce Vissel
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10.1371/journal.pone.0119204

PLOS ONE Small Peptide Inhibitor of JNK3 Protects Dopaminergic Neurons from MPTP Induced Injury via Inhibiting the ASK1-JNK3 Signaling Pathway
April 9, 2015 Jing Pan, Hui Li, Bei Zhang, Ran Xiong, Yu Zhang, Wen-Yan Kang, Wei Chen, Zong-Bo Zhao, Sheng-Di Chen
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10.1371/journal.pone.0135949

PLOS ONE Behavioural Assessment of the A_2a/NR2B Combination in the Unilateral 6-OHDA-Lesioned Rat Model: A New Method to Examine the Therapeutic Potential of Non-Dopaminergic Drugs
August 31, 2015 Anne Michel, Patrick Downey, Xavier Van Damme, Catherine De Wolf, Rainer Schwarting, Dieter Scheller
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10.1371/journal.pone.0116919

PLOS ONE The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson’s Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia
January 21, 2015 Xiqun Chen, Pauline Wales, Luisa Quinti, Fuxing Zuo, Sébastien Moniot, Fanny Herisson, Nazifa Abdul Rauf, Hua Wang, Richard B. Silverman, Cenk Ayata, Michelle M. Maxwell, Clemens Steegborn, Michael A. Schwarzschild, Tiago F. Outeiro, Aleksey G. Kazantsev
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10.1371/journal.pone.0125470

PLOS ONE Unexpected Dual Task Benefits on Cycling in Parkinson Disease and Healthy Adults: A Neuro-Behavioral Model
May 13, 2015 Lori J. P. Altmann, Elizabeth Stegemöller, Audrey A. Hazamy, Jonathan P. Wilson, Michael S. Okun, Nikolaus R. McFarland, Aparna Wagle Shukla, Chris J. Hass
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10.1371/journal.pone.0116473

PLOS ONE Identification of Synaptosomal Proteins Binding to Monomeric and Oligomeric α-Synuclein
February 6, 2015 Cristine Betzer, A. James Movius, Min Shi, Wei-Ping Gai, Jing Zhang, Poul Henning Jensen
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10.1371/journal.pone.0120819

PLOS ONE Genetic and Chemical Activation of TFEB Mediates Clearance of Aggregated α-Synuclein
March 19, 2015 Kiri Kilpatrick, Yimeng Zeng, Tommy Hancock, Laura Segatori
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10.1371/journal.pone.0151191

PLOS ONE Principal Component Analysis of Multimodal Neuromelanin MRI and Dopamine Transporter PET Data Provides a Specific Metric for the Nigral Dopaminergic Neuronal Density
March 8, 2016 Hiroshi Kawaguchi, Hitoshi Shimada, Fumitoshi Kodaka, Masayuki Suzuki, Hitoshi Shinotoh, Shigeki Hirano, Jeff Kershaw, Yuichi Inoue, Masaki Nakamura, Taeko Sasai, Mina Kobayashi, Tetsuya Suhara, Hiroshi Ito
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10.1371/journal.pone.0116841

PLOS ONE Anti-Human α-Synuclein N-Terminal Peptide Antibody Protects against Dopaminergic Cell Death and Ameliorates Behavioral Deficits in an AAV-α-Synuclein Rat Model of Parkinson’s Disease
February 6, 2015 Md Shahaduzzaman, Kevin Nash, Charles Hudson, Masroor Sharif, Bethany Grimmig, Xiaoyang Lin, Ge Bai, Hui Liu, Kenneth E. Ugen, Chuanhai Cao, Paula C. Bickford
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10.1371/journal.pone.0137432

PLOS ONE High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson’s Disease Model
September 11, 2015 Yan Kong, Xijun Liang, Lin Liu, Dongdong Zhang, Chao Wan, Zhenji Gan, Liudi Yuan
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10.1371/journal.pcbi.1004609

PLOS Computational Biology Computational Models Describing Possible Mechanisms for Generation of Excessive Beta Oscillations in Parkinson’s Disease
December 18, 2015 Alex Pavlides, S. John Hogan, Rafal Bogacz
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10.1371/journal.pgen.1005503

PLOS Genetics The Parkinson’s Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway
September 10, 2015 Yuzuru Imai, Yoshito Kobayashi, Tsuyoshi Inoshita, Hongrui Meng, Taku Arano, Kengo Uemura, Takeshi Asano, Kenji Yoshimi, Chang-Liang Zhang, Gen Matsumoto, Toshiyuki Ohtsuka, Ryoichiro Kageyama, Hiroshi Kiyonari, Go Shioi, Nobuyuki Nukina, Nobutaka Hattori, Ryosuke Takahashi
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10.1371/journal.pmed.1001854

PLOS Medicine Glitazone Treatment and Incidence of Parkinson’s Disease among People with Diabetes: A Retrospective Cohort Study
July 21, 2015 Ruth Brauer, Krishnan Bhaskaran, Nishi Chaturvedi, David T. Dexter, Liam Smeeth, Ian Douglas
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10.1371/journal.pcbi.1003517

PLOS Computational Biology Long Non-Coding RNA and Alternative Splicing Modulations in Parkinson’s Leukocytes Identified by RNA Sequencing
March 20, 2014 Lilach Soreq, Alessandro Guffanti, Nathan Salomonis, Alon Simchovitz, Zvi Israel, Hagai Bergman, Hermona Soreq
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10.1371/journal.pone.0106362

PLOS ONE Striatal Astrocytes Act as a Reservoir for L-DOPA
September 4, 2014 Masato Asanuma, Ikuko Miyazaki, Shinki Murakami, Francisco J. Diaz-Corrales, Norio Ogawa
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10.1371/journal.pone.0114216

PLOS ONE Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson’s Disease
December 8, 2014 Daniel Rial, Adalberto A. Castro, Nuno Machado, Pedro Garção, Francisco Q. Gonçalves, Henrique B. Silva, Ângelo R. Tomé, Attila Köfalvi, Olga Corti, Rita Raisman-Vozari, Rodrigo A. Cunha, Rui D. Prediger
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10.1371/journal.pgen.1004574

PLOS Genetics Dopamine Signaling Leads to Loss of Polycomb Repression and Aberrant Gene Activation in Experimental Parkinsonism
September 25, 2014 Erik Södersten, Michael Feyder, Mads Lerdrup, Ana-Luisa Gomes, Hanna Kryh, Giada Spigolon, Jocelyne Caboche, Gilberto Fisone, Klaus Hansen
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10.1371/journal.pgen.1004302

PLOS Genetics Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson’s Disease
May 8, 2014 Sandra Tenreiro, Madalena M. Reimão-Pinto, Pedro Antas, José Rino, Donata Wawrzycka, Diana Macedo, Rita Rosado-Ramos, Triana Amen, Meytal Waiss, Filipa Magalhães, Andreia Gomes, Cláudia N. Santos, Daniel Kaganovich, Tiago Fleming Outeiro
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10.1371/journal.pmed.1001462

PLOS Medicine Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study
June 4, 2013 Irene Pichler, Fabiola Del Greco M., Martin Gögele, Christina M. Lill, Lars Bertram, Chuong B. Do, Nicholas Eriksson, Tatiana Foroud, Richard H. Myers, PD GWAS Consortium , Michael Nalls, Margaux F. Keller, International Parkinson's Disease Genomics Consortium , Wellcome Trust Case Control Consortium 2 , Beben Benyamin, John B. Whitfield, Genetics of Iron Status Consortium , Peter P. Pramstaller, Andrew A. Hicks, John R. Thompson, Cosetta Minelli

Amyotrophic Lateral Sclerosis

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10.1371/journal.pone.0154971

PLOS ONE Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems
May 4, 2016 Panying Rong, Yana Yunusova, Jun Wang, Lorne Zinman, Gary L. Pattee, James D. Berry, Bridget Perry, Jordan R. Green
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10.1371/journal.pone.0147626

PLOS ONE Novel Neuroprotective Multicomponent Therapy for Amyotrophic Lateral Sclerosis Designed by Networked Systems
January 25, 2016 Mireia Herrando-Grabulosa, Roger Mulet, Albert Pujol, José Manuel Mas, Xavier Navarro, Patrick Aloy, Mireia Coma, Caty Casas
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10.1371/journal.pone.0147573

PLOS ONE Profiling Speech and Pausing in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)
January 20, 2016 Yana Yunusova, Naida L. Graham, Sanjana Shellikeri, Kent Phuong, Madhura Kulkarni, Elizabeth Rochon, David F. Tang-Wai, Tiffany W. Chow, Sandra E. Black, Lorne H. Zinman, Jordan R. Green
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10.1371/journal.pbio.1002338

PLOS Biology ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43
January 6, 2016 Liangzhong Lim, Yuanyuan Wei, Yimei Lu, Jianxing Song
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10.1371/journal.pone.0142546

PLOS ONE Eye Movement Deficits Are Consistent with a Staging Model of pTDP-43 Pathology in Amyotrophic Lateral Sclerosis
November 11, 2015 Martin Gorges, Hans-Peter Müller, Dorothée Lulé, Kelly Del Tredici, Johannes Brettschneider, Jürgen Keller, Katharina Pfandl, Albert C. Ludolph, Jan Kassubek, Elmar H. Pinkhardt
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10.1371/journal.pone.0118266

PLOS ONE A Comprehensive Library of Familial Human Amyotrophic Lateral Sclerosis Induced Pluripotent Stem Cells
March 11, 2015 Ying Li, Umamahesw Balasubramanian, Devon Cohen, Ping-Wu Zhang, Elizabeth Mosmiller, Rita Sattler, Nicholas J. Maragakis, Jeffrey D. Rothstein
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10.1371/journal.pone.0131114

PLOS ONE Susceptibility-Weighted Imaging Provides Insight into White Matter Damage in Amyotrophic Lateral Sclerosis
June 24, 2015 Tino Prell, Viktor Hartung, Florian Tietz, Susanne Penzlin, Benjamin Ilse, Ferdinand Schweser, Andreas Deistung, Martin Bokemeyer, Jürgen R. Reichenbach, Otto W. Witte, Julian Grosskreutz
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10.1371/journal.pone.0130162

PLOS ONE Defective Proteasome Delivery of Polyubiquitinated Proteins by Ubiquilin-2 Proteins Containing ALS Mutations
June 14, 2015 Lydia Chang, Mervyn J. Monteiro
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10.1371/journal.pone.0127376

PLOS ONE C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis
May 27, 2015 Johnathan Cooper-Knock, Joanna J. Bury, Paul R Heath, Matthew Wyles, Adrian Higginbottom, Catherine Gelsthorpe, J. Robin Highley, Guillaume Hautbergue, Magnus Rattray, Janine Kirby, Pamela J. Shaw
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10.1371/journal.pone.0119862

PLOS ONE Action Processing and Mirror Neuron Function in Patients with Amyotrophic Lateral Sclerosis: An fMRI Study
April 16, 2015 Laura Jelsone-Swain, Carol Persad, David Burkard, Robert C. Welsh
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10.1371/journal.pgen.1005107

PLOS Genetics Network Analyses Reveal Novel Aspects of ALS Pathogenesis
March 31, 2015 Mario Sanhueza, Andrea Chai, Colin Smith, Brett A. McCray, T. Ian Simpson, J. Paul Taylor, Giuseppa Pennetta
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10.1371/journal.pgen.1004704

PLOS Genetics Targeted Exon Capture and Sequencing in Sporadic Amyotrophic Lateral Sclerosis
October 9, 2014 Julien Couthouis, Alya R. Raphael, Roxana Daneshjou, Aaron D. Gitler
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10.1371/journal.pgen.1003895

PLOS Genetics ALS-Associated FUS Mutations Result in Compromised FUS Alternative Splicing and Autoregulation
October 31, 2013 Yueqin Zhou, Songyan Liu, Guodong Liu, Arzu Öztürk, Geoffrey G. Hicks
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10.1371/journal.pone.0082017

PLOS ONE Extramotor Damage Is Associated with Cognition in Primary Lateral Sclerosis Patients
December 5, 2013 Elisa Canu, Federica Agosta, Sebastiano Galantucci, Adriano Chiò, Nilo Riva, Vincenzo Silani, Andrea Falini, Giancarlo Comi, Massimo Filippi

Multiple Sclerosis

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10.1371/journal.pone.0117705

PLOS ONE Drug Repurposing: A Systematic Approach to Evaluate Candidate Oral Neuroprotective Interventions for Secondary Progressive Multiple Sclerosis
April 8, 2015 Hanna M. Vesterinen, Peter Connick, Cadi M. J. Irvine, Emily S. Sena, Kieren J. Egan, Gary G. Carmichael, Afiyah Tariq, Sue Pavitt, Jeremy Chataway, Malcolm R. Macleod, Siddharthan Chandran
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10.1371/journal.pone.0130442

PLOS ONE Nano-Drugs Based on Nano Sterically Stabilized Liposomes for the Treatment of Inflammatory Neurodegenerative Diseases
July 5, 2015 Keren Turjeman, Yaelle Bavli, Pablo Kizelsztein, Yaelle Schilt, Nahum Allon, Tamar Blumenfeld Katzir, Efrat Sasson, Uri Raviv, Haim Ovadia, Yechezkel Barenholz