Biology & Life Sciences

The Global Burden of Norovirus & Prospects for Vaccine Development

Published January 5, 2017 Partnered Collections, Special Issues

Each year, norovirus causes over 200,000 deaths and a global economic burden of more than $60 billion. A highly contagious virus that most people will contract 5 times in their lifetime, the most serious outcomes of the disease – hospitalization and death – are far more common among children and the elderly, and in low and middle income countries. In this PLOS Collection global norovirus experts fill critical knowledge gaps and provide key information to further development of a much-needed vaccine.

Image Credit: CDC

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Overview
Burden of Norovirus
Molecular Epidemiology
Natural History, Host-Pathogen Interaction
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Overview

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10.1371/journal.pmed.1001999

PLOS Medicine The Vast and Varied Global Burden of Norovirus: Prospects for Prevention and Control
April 26, 2016 Benjamin Lopman, Duncan Steele, Carl Kirkwood, Umesh Parashar

Burden of Norovirus

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10.1371/journal.pone.0158822

PLOS ONE Modelling Estimates of Norovirus Disease in Patients with Chronic Medical Conditions
July 20, 2016 Thomas Verstraeten, Baoguo Jiang, John Weil, Jennifer Lin
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10.1371/journal.pone.0151219

PLOS ONE Global Economic Burden of Norovirus Gastroenteritis
April 26, 2016 Sarah Bartsch, Benjamin Lopman, Sachiko Ozawa, Aron Hall, Bruce Lee
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10.1371/journal.pone.0148505

PLOS ONE Incidence of Norovirus-Associated Medical Encounters among Active Duty United States Military Personnel and Their Dependents
April 26, 2016 Brian Rha, Benjamin Lopman, Ashley Alcala, Mark Riddle, Chad Porter
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10.1371/journal.pone.0148395

PLOS ONE Incidence of Norovirus and Other Viral Pathogens That Cause Acute Gastroenteritis (AGE) among Kaiser Permanente Member Populations in the United States, 2012–2013
April 26, 2016 Scott Grytdal, Emilio DeBess, Lore Lee, David Blythe, Patricia Ryan, Christianne Biggs, Miriam Cameron, Mark Schmidt, Umesh Parashar, Aron Hall
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10.1371/journal.pone.0146280

PLOS ONE Norovirus Epidemiology in Africa: A Review
April 26, 2016 Janet Mans, George Armah, A Steele, Maureen Taylor
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10.1371/journal.pone.0145943

PLOS ONE Population-Based Incidence Rates of Diarrheal Disease Associated with Norovirus, Sapovirus, and Astrovirus in Kenya
April 26, 2016 Kayoko Shioda, Leonard Cosmas, Allan Audi, Nicole Gregoricus, Jan Vinjé, Umesh Parashar, Joel Montgomery, Daniel Feikin, Robert Breiman, Aron Hall

Molecular Epidemiology

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10.1371/journal.pone.0169491

PLOS ONE Norovirus and Sapovirus Epidemiology and Strain Characteristics among Navajo and Apache Infants
January 3, 2017 Lindsay Grant, Katherine O'Brien, Robert Weatherholtz, Raymond Reid, Novalene Goklish, Mathuram Santosham, Umesh Parashar, Jan Vinje
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10.1371/journal.pone.0157007

PLOS ONE Norovirus Gastroenteritis in a Birth Cohort in Southern India
June 9, 2016 Vipin Kumar Menon, Santosh George, Rajiv Sarkar, Sidhartha Giri, Prasanna Samuel, Rosario Vivek, Anuradha Saravanabavan, Farzana Begum Liakath, Sasirekha Ramani, Miren Iturriza-Gomara, James J. Gray, David W. Brown, Mary K. Estes, Gagandeep Kang
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10.1371/journal.pone.0145254

PLOS ONE A Multi-Site Study of Norovirus Molecular Epidemiology in Australia and New Zealand, 2013-2014
April 26, 2016 Kun Lee Lim, Joanne Hewitt, Alefiya Sitabkhan, John-Sebastian Eden, Jennifer Lun, Avram Levy, Juan Merif, David Smith, William Rawlinson, Peter White
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10.1371/journal.pone.0145391

PLOS ONE Norovirus Recombinant Strains Isolated from Gastroenteritis Outbreaks in Southern Brazil, 2004 – 2011
April 26, 2016 Tulio Fumian, Juliana da Silva Ribeiro de Andrade, José Paulo Leite, Marize Miagostovich
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10.1371/journal.pone.0146972

PLOS ONE Early Detection of Epidemic GII-4 Norovirus Strains in UK and Malawi: Role of Surveillance of Sporadic Acute Gastroenteritis in Anticipating Global Epidemics
April 26, 2016 David Allen, Eamonn Trainor, Anna Callaghan, Sarah O'Brien, Nigel Cunliffe, Miren Iturriza-Gomara

Natural History, Host-Pathogen Interaction

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10.1371/journal.ppat.1005385

PLOS Pathogens Innate Resistance and Susceptibility to Norovirus Infection
April 26, 2016 Johan Nordgren, Sumit Sharma, Anita Kambhampati, Ben Lopman, Lennart Svensson
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CDC

PLOS Pathogens Correlates of Protection against Norovirus Infection and Disease—Where Are We Now, Where Do We Go?
April 26, 2016 Sasirekha Ramani, Mary Estes, Robert Atmar
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10.1371/journal.pone.0143759

PLOS ONE Vomiting as a Symptom and Transmission Risk in Norovirus Illness: Evidence from Human Challenge Studies
April 26, 2016 Amy Kirby, Ashleigh Streby, Christine Moe
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10.1016/j.micinf.2015.12.004

Microbes and Infection Development and maturation of norovirus antibodies in childhood
January 13, 2016 Vesna Blazevic, Maria Malm, Hanna Honkanen, Mikael Knip, Heikki Hyöty, Timo Vesikari

More resources

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YouTube VIDEO: The Global Burden of Norovirus & Prospects for Vaccine Development
April 26, 2016 A Google Hangout with Ben Lopman, Carl Kirkwood and Miren Iturriza-Gomara
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CDC

Collections Blog Norovirus – A Tragedy Of Being Common
April 26, 2016 Ben Lopman
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CDC

Collections Blog What’s Norovirus Costing The World? | PLOS Collections
April 26, 2016 Bruce Y Lee
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CDC

Collections Blog What Factors Protect Against Norovirus Infection And Gastroenteritis? | PLOS Collections
April 27, 2016 Sasirekha Ramani, Mary Estes, Robert Atmar
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Lennart Svensson et al

Collections Blog Why Doesn’t Everyone Get Sick With Winter Vomiting Disease?
April 28, 2016 Lennart Svensson, Johan Nordgren, Sumit Sharma
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CDC

Collections Blog The Importance Of Detecting Sporadic Norovirus Cases In The Community
April 29, 2016 Miren Iturriza-Gómara, John Harris
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Reddit / PLOS

Reddit PLOS Science Wednesday: Hi Reddit, my name is Ben Lopman,Ask Me Anything! : science
May 11, 2016 Ben Lopman, Reddit Community