Biology & Life Sciences
Open Highlights: Understanding and Overcoming Antibiotic Resistance
Curated Collections
Given the importance of antibiotics to modern medicine, and the growing apprehension surrounding the threat of resistance, this Open Highlights Collection looks at the cellular mechanisms of antibiotic resistance, the evolution and spread of resistance, and techniques for combating resistance. Open Highlights use recent PLOS Biology research articles as keystones around which to nucleate a short synthesis of up to ten related research articles from other PLOS journals and from the wider Open Access corpus.
Image Credit: NIAID
Open Highlights
Related Open Access Articles
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PLOS Pathogens CpxR Activates MexAB-OprM Efflux Pump Expression and Enhances Antibiotic Resistance in Both Laboratory and Clinical nalB-Type Isolates of Pseudomonas aeruginosaOctober 13, 2016 Zhe-Xian Tian, Xue-Xian Yi, Anna Cho, Fergal O’Gara, Yi-Ping Wang
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eLife Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment | eLife LensFebruary 21, 2017 James E Gomez, Benjamin B Kaufmann-Malaga, Carl N Wivagg, Peter B Kim, Melanie R Silvis, Nikolai Renedo, Thomas R Ioerger, Rushdy Ahmad, Jonathan Livny, Skye Fishbein, James C Sacchettini, Steven A Carr, Deborah T Hung
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PLOS Biology Collective Resistance in Microbial Communities by Intracellular Antibiotic DeactivationDecember 27, 2016 Robin A. Sorg, Leo Lin, G. Sander van Doorn, Moritz Sorg, Joshua Olson, Victor Nizet, Jan-Willem Veening
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PLOS Biology Quantifying the Determinants of Evolutionary Dynamics Leading to Drug ResistanceNovember 18, 2015 Guillaume Chevereau, Marta Dravecká, Tugce Batur, Aysegul Guvenek, Dilay Hazal Ayhan, Erdal Toprak, Tobias Bollenbach
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PLOS Biology Multidrug-resistant bacteria compensate for the epistasis between resistancesApril 18, 2017 Jorge Moura de Sousa, Roberto Balbontín, Paulo Durão, Isabel Gordo
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Scientific Reports Emerging patterns of plasmid-host coevolution that stabilize antibiotic resistance | Scientific ReportsJuly 7, 2017 Thibault Stalder, Linda M. Rogers, Chris Renfrow, Hirokazu Yano, Zachary Smith & Eva M. Top
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PLOS Genetics Evidence for the evolutionary steps leading to mecA-mediated β-lactam resistance in staphylococciApril 10, 2017 Joana Rolo, Peder Worning, Jesper Boye Nielsen, Rita Sobral, Rory Bowden, Ons Bouchami, Peter Damborg, Luca Guardabassi, Vincent Perreten, Henrik Westh, Alexander Tomasz, Hermínia de Lencastre, Maria Miragaia
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PLOS Biology Using a Sequential Regimen to Eliminate Bacteria at Sublethal Antibiotic DosagesApril 8, 2015 Ayari Fuentes-Hernandez, Jessica Plucain, Fabio Gori, Rafael Pena-Miller, Carlos Reding, Gunther Jansen, Hinrich Schulenburg, Ivana Gudelj, Robert Beardmore
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PLOS Biology High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistanceJune 20, 2017 Morgan A. Wambaugh, Viplendra P. S. Shakya, Adam J. Lewis, Matthew A. Mulvey, Jessica C. S. Brown
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PLOS Computational Biology Using Chemical Reaction Kinetics to Predict Optimal Antibiotic Treatment StrategiesJanuary 6, 2017 Pia Abel zur Wiesch, Fabrizio Clarelli, Ted Cohen
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PLOS Computational Biology Integrating Antimicrobial Therapy with Host Immunity to Fight Drug-Resistant Infections: Classical vs. Adaptive TreatmentApril 14, 2016 Erida Gjini, Patricia H. Brito
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PLOS Biology Sequence-Specific Targeting of Bacterial Resistance Genes Increases Antibiotic EfficacySeptember 15, 2016 Dilay Hazal Ayhan, Yusuf Talha Tamer, Mohammed Akbar, Stacey M. Bailey, Michael Wong, Seth M. Daly, David E. Greenberg, Erdal Toprak
PLOS Biologue
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