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Pearls: Parasites

Published July 18, 2019 Curated Collections

PLOS Pathogens presents an Open Access compendium of the "lessons-that-last." This section, founded by Dr. Hiten Madhani and now led by Dr. Joseph Heitman and a team of twelve Pearls Editors, is a living collection of short educational and highly useful articles that address topics of relevance and importance within the wide-ranging field of pathogens research, with insights for trainees and scientists at all career stages.

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Parasites
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Parasites

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10.1371/journal.ppat.1007786

PLOS Pathogens Blood brain barrier disruption in cerebral malaria: Beyond endothelial cell activation
June 27, 2019 Arnulfo Tunon-Ortiz, Tracey J. Lamb
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NASA/Kathryn Hansen, 2011

PLOS Pathogens Born to sweet delight: Using natural models of malaria protection to understand and neutralize P. falciparum pathogenesis
June 20, 2019 Joseph W. Saelens, Steve M. Taylor
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10.1371/journal.ppat.1007661

PLOS Pathogens Plastid–endomembrane connections in apicomplexan parasites
June 13, 2019 Michael J. Boucher, Ellen Yeh
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10.1371/journal.ppat.1007670

PLOS Pathogens The triumvirate of signaling molecules controlling Toxoplasma microneme exocytosis: Cyclic GMP, calcium, and phosphatidic acid
May 23, 2019 Hayley E. Bullen, Hugo Bisio, Dominique Soldati-Favre
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10.1371/journal.ppat.1007668

PLOS Pathogens Ultimate opportunists—The emergent Enterocytozoon group Microsporidia
May 2, 2019 Grant D. Stentiford, David Bass, Bryony A. P. Williams
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10.1371/journal.ppat.1007351

PLOS Pathogens Mitochondrial protein import in trypanosomatids: Variations on a theme or fundamentally different?
November 29, 2018 André Schneider
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10.1371/journal.ppat.1007333

PLOS Pathogens Infection of anopheline mosquitoes with Wolbachia: Implications for malaria control
November 15, 2018 Fabio M. Gomes, Carolina Barillas-Mury
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10.1371/journal.ppat.1007250

PLOS Pathogens Five facts about Giardia lamblia
September 27, 2018 Lenka Cernikova, Carmen Faso, Adrian B. Hehl
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10.1371/journal.ppat.1007045

PLOS Pathogens Blood and guts: The intestinal vasculature during health and helminth infection
July 19, 2018 Irah King, Maria Gentile
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10.1371/journal.ppat.1007151

PLOS Pathogens PGL I expression in live bacteria allows activation of a CD206/PPARγ cross-talk that may contribute to successful Mycobacterium leprae colonization of peripheral nerves
July 6, 2018 Chyntia Carolina Díaz Acosta, André Alves Dias, Thabatta Leal Silveira Andrezo Rosa, Leonardo Ribeiro Batista-Silva, Patricia Sammarco Rosa, Thiago Gomes Toledo-Pinto, Fabrício da Mota Ramalho Costa, Flávio Alves Lara, Luciana Silva Rodrigues, Katherine Antunes Mattos, Euzenir Nunes Sarno, Patrícia Torres Bozza, Christophe Guilhot, Márcia de Berrêdo-Pinho, Maria Cristina Vidal Pessolani
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Gupta et al. (2018)

PLOS Pathogens Illuminating pathogen–host intimacy through optogenetics
July 12, 2018 Ruben Dario Arroyo-Olarte, Laura Thurow, Vera Kozjak-Pavlovic, Nishith Gupta
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10.1371/journal.ppat.1006923

PLOS Pathogens How to combat emerging artemisinin resistance: Lessons from “The Three Little Pigs”
April 26, 2018 Thanat Chookajorn
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10.1371/journal.ppat.1006926

PLOS Pathogens Metabolomics: Eavesdropping on silent conversations between hosts and their unwelcome guests
April 5, 2018 Sydney N. Newsom, Laura-Isobel McCall
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10.1371/journal.ppat.1006893

PLOS Pathogens Hostile intruder: Toxoplasma holds host organelles captive
March 29, 2018 Isabelle Coppens, Julia D. Romano
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10.1371/journal.ppat.1006831

PLOS Pathogens Does the common sexually transmitted parasite Trichomonas vaginalis have sex?
March 8, 2018 Martina Bradic, Jane Carlton
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10.1371/journal.ppat.1006590

PLOS Pathogens Circadian rhythms in parasites
October 12, 2017 Filipa Rijo-Ferreira, Joseph S. Takahashi, Luisa M. Figueiredo
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10.1371/journal.ppat.1006511

PLOS Pathogens Plasmodium heme biosynthesis: To be or not to be essential?
September 28, 2017 Daniel Goldberg, Paul Sigala
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10.1371/journal.ppat.1006523

PLOS Pathogens Cancer therapy in a microbial bottle: Uncorking the novel biology of the protozoan Toxoplasma gondii
September 14, 2017 Barbara A. Fox, Kiah L. Butler, Rebekah B. Guevara, David J. Bzik
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Amboo whoo? Flickr.com

PLOS Pathogens Consequences of insecticide resistance on malaria transmission
September 7, 2017 Haoues Alout, Benjamin Roche, Roch Dabiré, Anna Cohuet
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10.1371/journal.ppat.1006393

PLOS Pathogens Helminth infection–induced malignancy
July 27, 2017 Paul J. Brindley, Alex Loukas
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10.1371/journal.ppat.1006336

PLOS Pathogens Developing transmission-blocking strategies for malaria control
July 6, 2017 Robert Sinden
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10.1371/journal.ppat.1006303

PLOS Pathogens Leishmania enriettii (Muniz & Medina, 1948): A highly diverse parasite is here to stay
May 25, 2017 Larissa F. Paranaiba, Lucélia J. Pinheiro, Ana C. Torrecilhas, Diego H. Macedo, Armando Menezes-Neto, Wagner L. Tafuri, Rodrigo P. Soares
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10.1371/journal.ppat.1006176

PLOS Pathogens The human immune response to Toxoplasma: Autophagy versus cell death
March 9, 2017 Shruthi Krishnamurthy, Eleni K. Konstantinou, Lucy H. Young, Daniel A. Gold, Jeroen P. J. Saeij
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10.1371/journal.ppat.1006170

PLOS Pathogens Specialising the parasite nucleus: Pores, lamins, chromatin, and diversity
March 2, 2017 Michael Rout, Samson Obado, Sergio Schenkman, Mark Field
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10.1371/journal.ppat.1005962

PLOS Pathogens Exploitation of the Host Cell Membrane Fusion Machinery by Leishmania Is Part of the Infection Process
December 8, 2016 Christine Matte, Albert Descoteaux
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10.1371/journal.ppat.1005784

PLOS Pathogens Masters of Disguise: Antigenic Variation and the VSG Coat in Trypanosoma brucei
September 1, 2016 Monica Mugnier, C. Erec Stebbins, F. Nina Papavasiliou
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10.1371/journal.ppat.1005488

PLOS Pathogens Tick–Host–Pathogen Interactions: Conflict and Cooperation
April 21, 2016 José de la Fuente, Margarita Villar, Alejandro Cabezas-Cruz, Agustin Estrada-Pena, Nieves Ayllon, Pilar Alberdi
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10.1371/journal.ppat.1005492

PLOS Pathogens Trypanosome Mitochondrial Translation and Tetracycline: No Sweat about Tet
April 21, 2016 Hassan Hashimi, Sabine Kaltenbrunner, Alena Zíková, Julius Lukeš
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10.1371/journal.ppat.1005429

PLOS Pathogens Beg, Borrow and Steal: Three Aspects of Horizontal Gene Transfer in the Protozoan Parasite, Cryptosporidium parvum
March 3, 2016 Adam Sateriale, Boris Striepen
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10.1371/journal.ppat.1005396

PLOS Pathogens The Diverse Role of NK Cells in Immunity to Toxoplasma gondii Infection
February 25, 2016 Jason P. Gigley
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10.1371/journal.ppat.1005331

PLOS Pathogens The Link between Plasmodium falciparum Malaria and Endemic Burkitt’s Lymphoma—New Insight into a 50-Year-Old Enigma
January 21, 2016 David Thorley-Lawson, Kirk W. Deitsch, Karen A. Duca, Charles Torgbor
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10.1371/journal.ppat.1005353

PLOS Pathogens Epigenetic Roulette in Blood Stream Plasmodium: Gambling on Sex
February 11, 2016 Andrew P. Waters
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10.1371/journal.ppat.1005302

PLOS Pathogens A Mother’s Gift: Congenital Transmission of Trypanosoma and Leishmania Species
January 28, 2016 Tara Grinnage-Pulley, Benjamin Scott, Christine A. Petersen
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10.1371/journal.ppat.1005283

PLOS Pathogens The Development of Genetic Modification Techniques in Intracellular Parasites and Potential Applications to Microsporidia
December 31, 2015 Aaron W. Reinke, Emily R. Troemel
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10.1371/journal.ppat.1005272

PLOS Pathogens “With a Little Help from My Friends”—Social Motility in Trypanosoma brucei
December 17, 2015 Edwin A. Saada, Stephanie F. DeMarco, Michelle M. Shimogawa, Kent L. Hill
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10.1371/journal.ppat.1005169

PLOS Pathogens Parasite Glycobiology: A Bittersweet Symphony
November 12, 2015 Joao A. Rodrigues, Alvaro Acosta-Serrano, Markus Aebi, Michael A. J. Ferguson, Françoise H. Routier, Irene Schiller, Simão Soares, Daniel Spencer, Alexander Titz, Iain B. H. Wilson, Luis Izquierdo
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10.1371/journal.ppat.1005118

PLOS Pathogens Interferon-γ: The Jekyll and Hyde of Malaria
October 1, 2015 Thayer King, Tracey Lamb
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10.1371/journal.ppat.1005080

PLOS Pathogens Epicellular Apicomplexans: Parasites “On the Way In”
September 24, 2015 Pavla Bartošová-Sojková, Rebecca D. Oppenheim, Dominique Soldati-Favre, Julius Lukeš
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10.1371/journal.ppat.1005069

PLOS Pathogens Plasticity and Redundancy in Proteins Important for Toxoplasma Invasion
August 13, 2015 Karine Frénal, Dominique Soldati-Favre
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10.1371/journal.ppat.1005039

PLOS Pathogens Are Human Intestinal Eukaryotes Beneficial or Commensals?
August 13, 2015 Julius Lukeš, Christen Stensvold, Kateřina Jirků-Pomajbíková, Laura Wegener Parfrey
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10.1371/journal.ppat.1004926

PLOS Pathogens The Emerging Role for RNA Polymerase II in Regulating Virulence Gene Expression in Malaria Parasites
July 16, 2015 Uchechi E. Ukaegbu, Kirk W. Deitsch
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amboo who?, flickr

PLOS Pathogens Mechanisms of Host Behavioral Change in Toxoplasma gondii Rodent Association
July 23, 2015 Ajai Vyas
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10.1371/journal.ppat.1004805

PLOS Pathogens The Role of Horizontal Gene Transfer in the Evolution of the Oomycetes
May 27, 2015 Fiona Savory, Guy Leonard, Thomas A. Richards
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10.1371/journal.ppat.1004714

PLOS Pathogens Pathogens as Biological Weapons of Invasive Species
April 9, 2015 Andreas Vilcinskas
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PLOS

PLOS Pathogens Parasites and Their Heterophagic Appetite for Disease
May 21, 2015 Vern B. Carruthers
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10.1371/journal.ppat.1004438

PLOS Pathogens War and Infectious Diseases: Challenges of the Syrian Civil War
November 13, 2014 Sima L. Sharara, Souha S. Kanj
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10.1371/journal.ppat.1004140

PLOS Pathogens Helminth Infections, Type-2 Immune Response, and Metabolic Syndrome
July 3, 2014 Aprilianto Wiria, Erliyani Sartono, Taniawati Supali, Maria Yazdanbakhsh
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PLOS

PLOS Pathogens Parasite Extracellular Vesicles: Mediators of Intercellular Communication
August 28, 2014 Olivia Twu, Patricia J. Johnson
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10.1371/journal.ppat.1004120

PLOS Pathogens Multimeric Assembly of Host-Pathogen Adhesion Complexes Involved in Apicomplexan Invasion
June 12, 2014 May Paing, Niraj Tolia
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10.1371/journal.ppat.1004014

PLOS Pathogens Wormholes in Host Defense: How Helminths Manipulate Host Tissues to Survive and Reproduce
April 17, 2014 Deborah Boyett, Michael Hsieh
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10.1371/journal.ppat.1003680

PLOS Pathogens The Regulation of Trypanosome Gene Expression by RNA-Binding Proteins
November 7, 2013 Christine Clayton
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Feretzaki M, Heitman J (2013)

PLOS Pathogens Unisexual Reproduction Drives Evolution of Eukaryotic Microbial Pathogens
October 31, 2013 Marianna Feretzaki, Joseph Heitman
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10.1371/journal.ppat.1003594

PLOS Pathogens The Cell Biology of Leishmania: How to Teach Using Animations
October 10, 2013 Dirceu E. Teixeira, Marlene Benchimol, Juliany C. F. Rodrigues, Paulo H. Crepaldi, Paulo F. P. Pimenta, Wanderley de Souza
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10.1371/journal.ppat.1003552

PLOS Pathogens Feeding Uninvited Guests: mTOR and AMPK Set the Table for Intracellular Pathogens
October 3, 2013 Jason Brunton, Shaun Steele, Benjamin Ziehr, Nathaniel Moorman, Thomas Kawula
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10.1371/journal.ppat.1003489

PLOS Pathogens Host Immune Response to Intestinal Amebiasis
August 22, 2013 Shannon Moonah, Nona Jiang, William Petri
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10.1371/journal.ppat.1003488

PLOS Pathogens Asparagine Repeats in Plasmodium falciparum Proteins: Good for Nothing?
August 22, 2013 Vasant Muralidharan, Daniel Goldberg
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10.1371/journal.ppat.1003396

PLOS Pathogens It’s No Fluke: The Planarian as a Model for Understanding Schistosomes
July 18, 2013 James J. Collins, Phillip A. Newmark
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amboo who?, flickr

PLOS Pathogens Emerging Infectious Diseases: Threats to Human Health and Global Stability
July 4, 2013 David M. Morens, Anthony S. Fauci
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10.1371/journal.ppat.1003387

PLOS Pathogens Babesia: An Emerging Infectious Threat in Transfusion Medicine
July 11, 2013 Cheryl A. Lobo, Jeny R. Cursino-Santos, Andy Alhassan, Marilis Rodrigues
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amboo who?, flickr

PLOS Pathogens Have It Your Way: How Polymorphic, Injected Kinases and Pseudokinases Enable Toxoplasma to Subvert Host Defenses
April 25, 2013 John Boothroyd
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10.1371/journal.ppat.1003230

PLOS Pathogens Polyphosphate and Its Diverse Functions in Host Cells and Pathogens
May 2, 2013 Silvia Moreno, Roberto Docampo
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amboo who?, flickr

PLOS Pathogens Immune Regulation during Helminth Infections
April 18, 2013 Natasha Girgis, Uma Gundra, P'ng Loke
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10.1371/journal.ppat.1003227

PLOS Pathogens Parasites FeS Up: Iron-Sulfur Cluster Biogenesis in Eukaryotic Pathogens
April 4, 2013 Teegan A. Dellibovi-Ragheb, Jolyn E. Gisselberg, Sean T. Prigge
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10.1371/journal.ppat.1003089

PLOS Pathogens Loss and Retention of RNA Interference in Fungi and Parasites
January 24, 2013 Francisco E. Nicolás, Santiago Torres-Martínez, Rosa M. Ruiz-Vázquez
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10.1371/journal.ppat.1003088

PLOS Pathogens Make It, Take It, or Leave It: Heme Metabolism of Parasites
January 17, 2013 Luděk Kořený, Miroslav Oborník, Julius Lukeš
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10.1371/journal.ppat.1003045

PLOS Pathogens Inflammatory Responses Associated with the Induction of Cerebral Malaria: Lessons from Experimental Murine Models
December 27, 2012 Diana Hansen
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10.1371/journal.ppat.1002903

PLOS Pathogens Redefining Chronic Toxoplasmosis—A T Cell Exhaustion Perspective
October 11, 2012 Rajarshi Bhadra, Imtiaz A. Khan
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10.1371/journal.ppat.1002804

PLOS Pathogens Host Defense and Tolerance: Unique Challenges in the Placenta
August 9, 2012 Varvara Zeldovich, Anna Bakardjiev
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10.1371/journal.ppat.1002801

PLOS Pathogens Trichomonosis, a Common Curable STI, and Prostate Carcinogenesis—A Proposed Molecular Mechanism
August 9, 2012 Siobhan Sutcliffe, Calvin Neace, Nancy S. Magnuson, Raymond Reeves, J. F. Alderete
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10.1371/journal.ppat.1002794

PLOS Pathogens Phagocyte Responses to Protozoan Infection and How Toxoplasma gondii Meets the Challenge
August 2, 2012 Eric Denkers, Anne Schneider, Sara Cohen, Barbara Butcher
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10.1371/journal.ppat.1002775

PLOS Pathogens Gastrointestinal Cell Mediated Immunity and the Microsporidia
July 12, 2012 Magali Moretto, Imtiaz Khan, Louis Weiss
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10.1371/journal.ppat.1002619

PLOS Pathogens The Role of Mast Cells in the Defence against Pathogens
April 26, 2012 Mirjam Urb, Donald Sheppard
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10.1371/journal.ppat.1002545

PLOS Pathogens New Insights into Blastocystis spp.: A Potential Link with Irritable Bowel Syndrome
March 15, 2012 Philippe Poirier, Ivan Wawrzyniak, Christian Vivarès, Frédéric Delbac, Hicham El Alaoui
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amboo who?, flickr

PLOS Pathogens Sleeping with the Enemy: How Intracellular Pathogens Cope with a Macrophage Lifestyle
March 22, 2012 Emily Thi, Ulrike Lambertz, Neil Reiner
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10.1371/journal.ppat.1002535

PLOS Pathogens Taste for Blood: Hemoglobin as a Nutrient Source for Pathogens
March 8, 2012 Gleb Pishchany, Eric Skaar
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10.1371/journal.ppat.1002404

PLOS Pathogens Sexual Development in Plasmodium: Lessons from Functional Analyses
January 19, 2012 David Guttery, Anthony Holder, Rita Tewari
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amboo who?, flickr

PLOS Pathogens How Do Microbial Pathogens Make CENs?
February 9, 2012 Kaustuv Sanyal
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10.1371/journal.ppat.1002400

PLOS Pathogens Sequence Divergent RXLR Effectors Share a Structural Fold Conserved across Plant Pathogenic Oomycete Species
January 12, 2012 Joe Win, Ksenia Krasileva, Sophien Kamoun, Ken Shirasu, Brian Staskawicz, Mark Banfield
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10.1371/journal.ppat.1002323

PLOS Pathogens Five Questions about Non-Mevalonate Isoprenoid Biosynthesis
December 22, 2011 Audrey Odom
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10.1371/journal.ppat.1002003

PLOS Pathogens Evolution of Th2 Immunity: A Rapid Repair Response to Tissue Destructive Pathogens
May 12, 2011 Judith Allen, Thomas Wynn
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amboo who?, flickr

PLOS Pathogens Exploiting and Subverting Tor Signaling in the Pathogenesis of Fungi, Parasites, and Viruses
September 29, 2011 Cecelia Shertz, Maria Cardenas
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10.1371/journal.ppat.1001310

PLOS Pathogens Innate Immune Sensing of DNA
April 21, 2011 Shruti Sharma, Katherine A. Fitzgerald
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10.1371/journal.ppat.1001243

PLOS Pathogens New Models of Microsporidiosis: Infections in Zebrafish, C. elegans, and Honey Bee
February 17, 2011 Emily R. Troemel
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10.1371/journal.ppat.1000649

PLOS Pathogens Advances in Parasite Genomics: From Sequences to Regulatory Networks
October 30, 2009 Elizabeth A. Winzeler
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10.1371/journal.ppat.1000489

PLOS Pathogens Five Questions about Microsporidia
September 25, 2009 Patrick Keeling

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January 5, 2017 Joseph Heitman
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