Medicine & Health

Personalized Medicine

Published June 30, 2022 Curated Collections

PLOS ONE presents a curated collection of pioneering research in the field of Personalized Medicine. This collection demonstrates the exciting range of interdisciplinary work published by PLOS ONE authors, with topics ranging from new genomic techniques for diagnosis to pharmacological development of precision treatments.

The collection also highlights PLOS ONE’s commitment to Open Science, featuring code sharing and open data. 

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10.1371/journal.pone.0259137 CC BY 4.0

PLOS ONE A rapid, simple and sensitive LC-MS/MS method for lenvatinib quantification in human plasma for therapeutic drug monitoring
October 26, 2021 Martina Zanchetta, Valentina Iacuzzi, Bianca Posocco, Giorgia Bortolin, Ariana Soledad Poetto, Marco Orleni, Giovanni Canil, Michela Guardascione, Luisa Foltran, Valentina Fanotto, Fabio Puglisi, Sara Gagno, Giuseppe Toffoli

Lenvatinib (LENVA) is an oral antineoplastic drug used for the treatment of hepatocellular carcinoma and thyroid carcinoma. LENVA…
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10.1371/journal.pone.0258571 CC BY 4.0

PLOS ONE The limits of personalization in precision medicine: Polygenic risk scores and racial categorization in a precision breast cancer screening trial
October 29, 2021 Jennifer Elyse James, Leslie Riddle, Barbara Ann Koenig, Galen Joseph

Population-based genomic screening is at the forefront of a new approach to disease prevention. Yet the lack of diversity in genome wide…
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10.1371/journal.pone.0253611 CC BY 4.0

PLOS ONE Identification of novel and rare variants associated with handgrip strength using whole genome sequence data from the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program
July 2, 2021 Chloé Sarnowski, Han Chen, Mary L. Biggs, Sylvia Wassertheil-Smoller, Jan Bressler, Marguerite R. Irvin, Kathleen A. Ryan, David Karasik, Donna K. Arnett, L. Adrienne Cupples, David W. Fardo, Stephanie M. Gogarten, Benjamin D. Heavner, Deepti Jain, Hyun Min Kang, Charles Kooperberg, Arch G. Mainous, Braxton D. Mitchell, Alanna C. Morrison, Jeffrey R. O’Connell, Bruce M. Psaty, Kenneth Rice, Albert V. Smith, Ramachandran S. Vasan, B. Gwen Windham, Douglas P. Kiel, Joanne M. Murabito, Kathryn L. Lunetta, on behalf of the TOPMed Longevity and Healthy Aging Working Group , from the NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium

Handgrip strength is a widely used measure of muscle strength and a predictor of a range of morbidities including cardiovascular diseases…
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10.1371/journal.pone.0247837 CC BY 4.0

PLOS ONE The overexpression of DNA repair genes in invasive ductal and lobular breast carcinomas: Insights on individual variations and precision medicine
March 4, 2021 Ruwaa I. Mohamed, Salma A. Bargal, Asmaa S. Mekawy, Iman El-Shiekh, Nurcan Tuncbag, Alaa S. Ahmed, Eman Badr, Menattallah Elserafy

In the era of precision medicine, analyzing the transcriptomic profile of patients is essential to tailor the appropriate therapy. In this…
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10.1371/journal.pone.0234833 CC BY 4.0

PLOS ONE Factors influencing precision medicine knowledge and attitudes
November 11, 2020 Rohini Chakravarthy, Sarah C. Stallings, Michael Williams, Megan Hollister, Mario Davidson, Juan Canedo, Consuelo H. Wilkins

Precision medicine holds great promise for improving health and reducing health disparities that can be most fully realized by advancing…
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10.1371/journal.pone.0231826 CC BY 4.0

PLOS ONE Advancing clinical cohort selection with genomics analysis on a distributed platform
April 23, 2020 Jaclyn M. Smith, Melvin Lathara, Hollis Wright, Brian Hill, Nalini Ganapati, Ganapati Srinivasa, Christopher T. Denny

The affordability of next-generation genomic sequencing and the improvement of medical data management have contributed largely to the…
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10.1371/journal.pone.0228188 CC BY 4.0

PLOS ONE Precision medicine and actionable alterations in lung cancer: A single institution experience
February 11, 2020 Isa Mambetsariev, Yingyu Wang, Chen Chen, Sorena Nadaf, Rebecca Pharaon, Jeremy Fricke, Idoroenyi Amanam, Arya Amini, Andrea Bild, Peiguo Chu, Loretta Erhunmwunsee, Jae Kim, Janet Munu, Raju Pillai, Dan Raz, Sagus Sampath, Lalit Vora, Fang Qiu, Lynette Smith, Surinder K. Batra, Erminia Massarelli, Marianna Koczywas, Karen Reckamp, Ravi Salgia

Objectives: Oncology has become more reliant on new testing methods and a greater use of electronic medical records, which provide a…
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10.1371/journal.pone.0226564 CC BY 4.0

PLOS ONE Application of pharmacogenomics and bioinformatics to exemplify the utility of human ex vivo organoculture models in the field of precision medicine
December 20, 2019 Karen Cowan, Graeme Macluskie, Michael Finch, Colin N. A. Palmer, Jane Hair, Max Bylesjo, Sarah Lynagh, Pamela Brankin, Marian McNeil, Carolyn Low, David Mallinson, Elaine M. Gourlay, Hannah Child, Linda Cheyne, David C. Bunton

Here we describe a collaboration between industry, the National Health Service (NHS) and academia that sought to demonstrate how early…
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10.1371/journal.pone.0224227 CC BY 4.0

PLOS ONE Discovery of actionable genetic alterations with targeted panel sequencing in children with relapsed or refractory solid tumors
November 20, 2019 Ji Won Lee, Nayoung K. D. Kim, Soo Hyun Lee, Hee Won Cho, Youngeun Ma, Hee Young Ju, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo, Woong-Yang Park

Advances in genomic technologies and the development of targeted therapeutics are making the use of precision medicine increasingly…
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10.1371/journal.pone.0215508 CC BY 4.0

PLOS ONE In silico analysis of the V66M variant of human BDNF in psychiatric disorders: An approach to precision medicine
April 18, 2019 Clara Carolina Silva De Oliveira, Gabriel Rodrigues Coutinho Pereira, Jamile Yvis Santos De Alcantara, Deborah Antunes, Ernesto Raul Caffarena, Joelma Freire De Mesquita

Brain-derived neurotrophic factor (BDNF) plays an important role in neurogenesis and synapse formation. The V66M is the most prevalent…
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10.1371/journal.pone.0205155 CC BY 4.0

PLOS ONE A quantile regression forest based method to predict drug response and assess prediction reliability
October 5, 2018 Yun Fang, Peirong Xu, Jialiang Yang, Yufang Qin

Drug response prediction is a critical step for personalized treatment of cancer patients and ultimately leads to precision medicine. A…
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10.1371/journal.pone.0186906 CC BY 4.0

PLOS ONE Open source machine-learning algorithms for the prediction of optimal cancer drug therapies
October 26, 2017 Cai Huang, Roman Mezencev, John F. McDonald, Fredrik Vannberg

Precision medicine is a rapidly growing area of modern medical science and open source machine-learning codes promise to be a critical…
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10.1371/journal.pone.0186175 CC BY 4.0

PLOS ONE Comprehensive benchmarking of SNV callers for highly admixed tumor data
October 11, 2017 Regina Bohnert, Sonia Vivas, Gunther Jansen

Precision medicine attempts to individualize cancer therapy by matching tumor-specific genetic changes with effective targeted therapies.…
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10.1371/journal.pone.0179575 CC BY 4.0

PLOS ONE Model-based optimization approaches for precision medicine: A case study in presynaptic dopamine overactivity
June 14, 2017 Kai-Cheng Hsu, Feng-Sheng Wang

Precision medicine considers an individual’s unique physiological characteristics as strongly influential in disease vulnerability and in…
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10.1371/journal.pone.0160519 CC BY 4.0

PLOS ONE Lollipops in the Clinic: Information Dense Mutation Plots for Precision Medicine
August 4, 2016 Jeremy J. Jay, Cory Brouwer

Introduction: Concise visualization is critical to present large amounts of information in a minimal space that can be interpreted quickly.…
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10.1371/journal.pone.0160461 CC BY 4.0

PLOS ONE A Survey of U.S Adults’ Opinions about Conduct of a Nationwide Precision Medicine Initiative® Cohort Study of Genes and Environment
August 17, 2016 David J. Kaufman, Rebecca Baker, Lauren C. Milner, Stephanie Devaney, Kathy L. Hudson

Objectives: A survey of a population-based sample of U.S adults was conducted to measure their attitudes about, and inform the design of…
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10.1371/journal.pone.0134869 CC BY 4.0

PLOS ONE Towards Personalized Cardiology: Multi-Scale Modeling of the Failing Heart
July 31, 2015 Elham Kayvanpour, Tommaso Mansi, Farbod Sedaghat-Hamedani, Ali Amr, Dominik Neumann, Bogdan Georgescu, Philipp Seegerer, Ali Kamen, Jan Haas, Karen S. Frese, Maria Irawati, Emil Wirsz, Vanessa King, Sebastian Buss, Derliz Mereles, Edgar Zitron, Andreas Keller, Hugo A. Katus, Dorin Comaniciu, Benjamin Meder

Background: Despite modern pharmacotherapy and advanced implantable cardiac devices, overall prognosis and quality of life of HF patients…
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10.1371/journal.pone.0116933 CC BY 4.0

PLOS ONE Early Intervention for Spinal Cord Injury with Human Induced Pluripotent Stem Cells Oligodendrocyte Progenitors
January 30, 2015 Angelo H. All, Payam Gharibani, Siddharth Gupta, Faith A. Bazley, Nikta Pashai, Bin-Kuan Chou, Sandeep Shah, Linda M. Resar, Linzhao Cheng, John D. Gearhart, Candace L. Kerr

Induced pluripotent stem (iPS) cells are at the forefront of research in regenerative medicine and are envisaged as a source for…
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10.1371/journal.pone.0083875 CC BY 4.0

PLoS ONE The Personalized Advantage Index: Translating Research on Prediction into Individualized Treatment Recommendations. A Demonstration
January 8, 2014 Robert J. DeRubeis, Zachary D. Cohen, Nicholas R. Forand, Jay C. Fournier, Lois A. Gelfand, Lorenzo Lorenzo-Luaces

Background: Advances in personalized medicine require the identification of variables that predict differential response to treatments as…
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10.1371/journal.pone.0082562 CC BY 4.0

PLoS ONE Polymorphic Cytochrome P450 Enzymes (CYPs) and Their Role in Personalized Therapy
December 10, 2013 Sarah C. Preissner, Michael F. Hoffmann, Robert Preissner, Mathias Dunkel, Andreas Gewiess, Saskia Preissner

The cytochrome P450 (CYP) enzymes are major players in drug metabolism. More than 2,000 mutations have been described, and certain…
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10.1371/journal.pone.0059909 CC BY 4.0

PLoS ONE Human Breath Analysis May Support the Existence of Individual Metabolic Phenotypes
April 3, 2013 Pablo Martinez-Lozano Sinues, Malcolm Kohler, Renato Zenobi

The metabolic phenotype varies widely due to external factors such as diet and gut microbiome composition, among others. Despite…

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