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As we launch our curated collection of Radiochemistry research, we chat with Dr. Tara Mastren about her work in nuclear medicine, life as an Early Career Researcher, and Open Science.
Physics Chemistry & Materials
Radiochemistry
Radionuclides (the radioactive form of elements) have an extensive array of uses in scientific research – in archeology they can provide valuable timelines of past histories, while in nuclear medicine they can be harnessed to combat cancerous cells. They also have applications in ecology, oceanography, chemistry, and numerous other fields, making them an invaluable research tool.
Here, we present a curated collection of recent studies featuring the use of radioisotopes. The collection highlights the wide variety of ways that these elements can be used by researchers and showcases innovations in a number of fields.
Image Credit: 10.1371/journal.pone.0247167 CC BY 4.0
From the Blog
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Image creditMedical radioisotopes by Oak Ridge National Laboratory, CC BY 2.0EveryONE An Interview with PLOS ONE Editorial Board Member, Professor Tara Mastren
PLOS ONE
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PLOS ONE Preliminary evaluation of alpha-emitting radioembolization in animal models of hepatocellular carcinoma
Hepatocellular carcinoma is the most common primary liver cancer and the fifth most frequently diagnosed cancer worldwide. Most patients…
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PLOS ONE Bias evaluation and reduction in 3D OP-OSEM reconstruction in dynamic equilibrium PET studies with 11C-labeled for binding potential analysis
Iterative image reconstruction is widely used in positron emission tomography. However, it is known to contribute to quantitation bias and…
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PLOS ONE Dating the megalithic culture of laos: Radiocarbon, optically stimulated luminescence and U/Pb zircon results
The megalithic jar sites of Laos (often referred to as the Plain of Jars) remain one of Southeast Asia’s most mysterious and least…
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PLOS ONE Radon-220 diffusion from 224Ra-labeled calcium carbonate microparticles: Some implications for radiotherapeutic use
Alpha-particle emitting radionuclides continue to be the subject of medical research because of their high energy and short range of…
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PLOS ONE Radiocarbon in otoliths of tropical marine fishes: Reference Δ14C chronology for north Caribbean waters
Reef fishes support important fisheries throughout the Caribbean, but a combination of factors in the tropics makes otolith microstructure…
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PLOS ONE A real-world evaluation of radium-223 in combination with abiraterone or enzalutamide for the treatment of metastatic castration-resistant prostate cancer
Introduction: Radium-223, abiraterone, and enzalutamide have each been shown to significantly improve survival as monotherapy in patients…
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PLOS ONE Single-cell radioluminescence microscopy with two-fold higher sensitivity using dual scintillator configuration
Radioluminescence microscopy (RLM) is an imaging technique that allows quantitative analysis of clinical radiolabeled drugs and probes in…
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PLOS ONE Feasibility of real-time in vivo 89Zr-DFO-labeled CAR T-cell trafficking using PET imaging
Introduction: Chimeric antigen receptor (CAR) T-cells have been recently developed and are producing impressive outcomes in patients with…
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PLOS ONE Incorporation characteristics of exogenous 15N-labeled thymidine, deoxyadenosine, deoxyguanosine and deoxycytidine into bacterial DNA
Bacterial production has been often estimated from DNA synthesis rates by using tritium-labeled thymidine. Some bacteria species cannot…
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PLOS ONE Targeted alpha therapy for chronic lymphocytic leukaemia and non-Hodgkin’s lymphoma with the anti-CD37 radioimmunoconjugate 212Pb-NNV003
Relapse of chronic lymphocytic leukaemia and non-Hodgkin’s lymphoma after standard of care treatment is common and new therapies are…
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PLOS ONE The southern Gulf of Mexico: A baseline radiocarbon isoscape of surface sediments and isotopic excursions at depth
The southern Gulf of Mexico (sGoM) is home to an extensive oil recovery and development infrastructure. In addition, the basin harbors…
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PLOS ONE Radioimmunotherapy of methicillin-resistant Staphylococcus aureus in planktonic state and biofilms
Background: Implant associated infections such as periprosthetic joint infections are difficult to treat as the bacteria form a biofilm on…
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PLOS ONE Separation and recovery of exotic radiolanthanides from irradiated tantalum targets for half-life measurements
The current knowledge of the half-lives (T1/2) of several radiolanthanides is either affected by a high uncertainty or is still awaiting…
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PLOS ONE Rapid radiation of humans in South America after the last glacial maximum: A radiocarbon-based study
The early peopling of the Americas has been one of the most hotly contested topics in American anthropology and a research issue that…
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PLOS ONE Coral Gardens Reef, Belize: A refugium in the face of Caribbean-wide Acropora spp. coral decline
Caribbean Acropora spp. corals have undergone a decline in cover since the second half of the twentieth century. Loss of these…
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PLOS ONE Radiocesium concentrations in mushrooms collected in Kawauchi Village five to eight years after the Fukushima Daiichi Nuclear Power Plant accident
Following the Fukushima Daiichi Nuclear Power Plant accident in March 2011, radionuclides such as iodine-131, cesium-134 and cesium-137…
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PLOS ONE 68Ga-PSMA-PET/CT-based radiosurgery and stereotactic body radiotherapy for oligometastatic prostate cancer
Background: Androgen deprivation therapy (ADT) remains the standard therapy for patients with oligometastatic prostate cancer (OMPC).…
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PLOS ONE PET imaging and pharmacological therapy targeting carbonic anhydrase-IX high-expressing tumors using US2 platform based on bivalent ureidosulfonamide
Carbonic anhydrase-IX (CA-IX) is attracting much attention as a target molecule for cancer treatment since high expression of CA-IX can…
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PLOS ONE 68Ga-Galmydar: A PET imaging tracer for noninvasive detection of Doxorubicin-induced cardiotoxicity
Background: Cancer patients undergoing Doxorubicin (DOX) treatment are susceptible to acute and chronic cardiac anomalies, including…
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PLOS ONE An one-pot two-step automated synthesis of [18F]T807 injection, its biodistribution in mice and monkeys, and a preliminary study in humans
[18F]T807 is a potent tau protein imaging agent. In order to fulfill the demand from preclinical and clinical studies, we developed an…
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PLOS ONE Radiocarbon dating and cultural dynamics across Mongolia’s early pastoral transition
The emergence of mobile herding lifeways in Mongolia and eastern Eurasia was one of the most crucial economic and cultural transitions in…
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PLOS ONE Radiocarbon, Bayesian chronological modeling and early European metal circulation in the sixteenth-century AD Mohawk River Valley, USA
European metal artifacts in assemblages from sites predating the physical presence of Europeans in Northern Iroquoia in present-day New…