Medicine & Health

Sleeping Sickness

Published June 8, 2016 Curated Collections

In the February 2011 issue of PLOS Neglected Tropical Diseases (PLOS NTDs), Simarro and colleagues report in "The Human African Trypanosomiasis Control and Surveillance Programme of the World Health Organization 2000-2009: The Way Forward" that new cases of human African trypanosomiasis (HAT), more familiarly known as sleeping sickness, fell below 10,000 in 2009, perhaps signaling the end to this epidemic cycle. Deputy Editor-in-Chief Serap Aksoy elaborates on this finding in her editorial, titled "Sleeping Sickness Elimination in Sight: Time to Celebrate, Reflect but not Relax." To highlight the existing literature PLOS NTDs authors have contributed to the field, Dr. Aksoy combed the archives to find those articles on HAT that we have published with potential applications for disease control.

Image Credit: Pere P. Simarro, World Health Organization

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Editorial
From Innovation to Application
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Research Articles

Editorial

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Pere P. Simarro, World Health Organization

PLOS Neglected Tropical Diseases Sleeping Sickness Elimination in Sight: Time to Celebrate and Reflect, but Not Relax
February 22, 2011 Serap Aksoy

From Innovation to Application

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10.1371/journal.pntd.0000471

PLOS Neglected Tropical Diseases Improved Models of Mini Anion Exchange Centrifugation Technique (mAECT) and Modified Single Centrifugation (MSC) for Sleeping Sickness Diagnosis and Staging
November 24, 2009 Philippe Büscher, Dieudonné Mumba Ngoyi, Jacques Kaboré, Veerle Lejon, Jo Robays, Vincent Jamonneau, Nicolas Bebronne, Wim Van der Veken, Sylvain Biéler

Viewpoints

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10.1371/journal.pntd.0000715

PLOS Neglected Tropical Diseases “Piggy-Backing” on Diagnostic Platforms Brings Hope to Neglected Diseases: The Case of Sleeping Sickness
May 25, 2010 Joseph Mathu Ndung'u, Sylvain Bieler, Giorgio Roscigno
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10.1371/journal.pntd.0000720

PLOS Neglected Tropical Diseases NECT Is Next: Implementing the New Drug Combination Therapy for Trypanosoma brucei gambiense Sleeping Sickness
May 25, 2010 Oliver Yun, Gerardo Priotto, Jacqueline Tong, Laurence Flevaud, François Chappuis
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10.1371/journal.pntd.0000907

PLOS Neglected Tropical Diseases Factory Tsetse Flies Must Behave Like Wild Flies: A Prerequisite for the Sterile Insect Technique
February 22, 2011 Marc J. B. Vreysen, Khalfan M. Saleh, Renaud Lancelot, Jérémy Bouyer
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10.1371/journal.pntd.0001007

PLOS Neglected Tropical Diseases The Human African Trypanosomiasis Control and Surveillance Programme of the World Health Organization 2000–2009: The Way Forward
February 22, 2011 Pere Simarro, Abdoulaye Diarra, Jose Ruiz Postigo, José Franco, Jean Jannin

Research Articles

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10.1371/journal.pntd.0000147

PLOS Neglected Tropical Diseases Loop-Mediated Isothermal Amplification (LAMP) Method for Rapid Detection of Trypanosoma brucei rhodesiense
February 6, 2008 Zablon Kithinji Njiru, Andrew Stanislaw John Mikosza, Tanya Armstrong, John Charles Enyaru, Joseph Mathu Ndung'u, Andrew Richard Christopher Thompson
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10.1371/journal.pntd.0000435

PLOS Neglected Tropical Diseases Prospects for Developing Odour Baits To Control Glossina fuscipes spp., the Major Vector of Human African Trypanosomiasis
May 12, 2009 Maurice O. Omolo, Ahmed Hassanali, Serge Mpiana, Johan Esterhuizen, Jenny Lindh, Mike J. Lehane, Philippe Solano, Jean Baptiste Rayaisse, Glyn A. Vale, Steve J. Torr, Inaki Tirados
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10.1371/journal.pntd.0000459

PLOS Neglected Tropical Diseases A Combined CXCL10, CXCL8 and H-FABP Panel for the Staging of Human African Trypanosomiasis Patients
June 16, 2009 Alexandre Hainard, Natalia Tiberti, Xavier Robin, Veerle Lejon, Dieudonné Mumba Ngoyi, Enock Matovu, John Charles Enyaru, Catherine Fouda, Joseph Mathu Ndung'u, Frédérique Lisacek, Markus Müller, Natacha Turck, Jean-Charles Sanchez
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10.1371/journal.pntd.0000474

PLOS Neglected Tropical Diseases Improving the Cost-Effectiveness of Artificial Visual Baits for Controlling the Tsetse Fly Glossina fuscipes fuscipes
July 7, 2009 Jenny M. Lindh, Steve J. Torr, Glyn A. Vale, Mike J. Lehane
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10.1371/journal.pntd.0000563

PLOS Neglected Tropical Diseases Spatial Predictions of Rhodesian Human African Trypanosomiasis (Sleeping Sickness) Prevalence in Kaberamaido and Dokolo, Two Newly Affected Districts of Uganda
December 15, 2009 Nicola A. Batchelor, Peter M. Atkinson, Peter W. Gething, Kim Picozzi, Eric M. Fèvre, Abbas S. L. Kakembo, Susan C. Welburn
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10.1371/journal.pntd.0000495

PLOS Neglected Tropical Diseases Preclinical Assessment of the Treatment of Second-Stage African Trypanosomiasis with Cordycepin and Deoxycoformycin
August 4, 2009 Suman K. Vodnala, Marcela Ferella, Hilda Lundén-Miguel, Evans Betha, Nick van Reet, Daniel Ndem Amin, Bo Öberg, Björn Andersson, Krister Kristensson, Hans Wigzell, Martin E. Rottenberg
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10.1371/journal.pntd.0000636

PLOS Neglected Tropical Diseases Phylogeography and Population Structure of Glossina fuscipes fuscipes in Uganda: Implications for Control of Tsetse
March 16, 2010 Jon S. Beadell, Chaz Hyseni, Patrick P. Abila, Rogers Azabo, John C. K. Enyaru, Johnson O. Ouma, Yassir O. Mohammed, Loyce M. Okedi, Serap Aksoy, Adalgisa Caccone
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10.1371/journal.pntd.0000692

PLOS Neglected Tropical Diseases Population Genetics as a Tool to Select Tsetse Control Strategies: Suppression or Eradication of Glossina palpalis gambiensis in the Niayes of Senegal
May 25, 2010 Philippe Solano, Dramane Kaba, Sophie Ravel, Naomi A. Dyer, Baba Sall, Marc J. B. Vreysen, Momar T. Seck, Heather Darbyshir, Laetitia Gardes, Martin J. Donnelly, Thierry De Meeûs, Jérémy Bouyer
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10.1371/journal.pntd.0000632

PLOS Neglected Tropical Diseases Prospects for the Development of Odour Baits to Control the Tsetse Flies Glossina tachinoides and G. palpalis s.l.
March 16, 2010 J. B. Rayaisse, I. Tirados, D. Kaba, S. Y. Dewhirst, J. G. Logan, A. Diarrassouba, E. Salou, M. O. Omolo, P. Solano, M. J. Lehane, J. A. Pickett, G. A. Vale, S. J. Torr, J. Esterhuizen
Image credit
Pere P. Simarro, World Health Organization

PLOS Neglected Tropical Diseases Phase II Evaluation of Sensitivity and Specificity of PCR and NASBA Followed by Oligochromatography for Diagnosis of Human African Trypanosomiasis in Clinical Samples from D.R. Congo and Uganda
July 6, 2010 Enock Matovu, Claire M. Mugasa, Rosine Ali Ekangu, Stijn Deborggraeve, George W. Lubega, Thierry Laurent, Gerard J. Schoone, Henk D. Schallig, Philippe Büscher
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10.1371/journal.pntd.0000865

PLOS Neglected Tropical Diseases LAMP for Human African Trypanosomiasis: A Comparative Study of Detection Formats
November 2, 2010 Sally L. Wastling, Kim Picozzi, Abbas S. L. Kakembo, Susan C. Welburn
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10.1371/journal.pntd.0000923

PLOS Neglected Tropical Diseases Fexinidazole – A New Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness
December 21, 2010 Els Torreele, Bernadette Bourdin Trunz, David Tweats, Marcel Kaiser, Reto Brun, Guy Mazué, Michael A. Bray, Bernard Pécoul
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10.1371/journal.pntd.0000917

PLOS Neglected Tropical Diseases Revisiting the Immune Trypanolysis Test to Optimise Epidemiological Surveillance and Control of Sleeping Sickness in West Africa
December 21, 2010 Vincent Jamonneau, Bruno Bucheton, Jacques Kaboré, Hamidou Ilboudo, Oumou Camara, Fabrice Courtin, Philippe Solano, Dramane Kaba, Roger Kambire, Kouakou Lingue, Mamadou Camara, Rudy Baelmans, Veerle Lejon, Philippe Büscher
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10.1371/journal.pntd.0000914

PLOS Neglected Tropical Diseases Bayesian Geostatistical Analysis and Prediction of Rhodesian Human African Trypanosomiasis
December 21, 2010 Nicola A. Wardrop, Peter M. Atkinson, Peter W. Gething, Eric M. Fèvre, Kim Picozzi, Abbas S. L. Kakembo, Susan C. Welburn

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Providing access to diagnosis of affected population through mass screening in disease-endemic areas by mobile teams and subsequent treatment has been the basis of the methodology to reduce transmission of human African trypanosomiasis.

Simarro et al.

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