Medicine & Health

Starworms

Published September 30, 2020 Partnered Collections, Special Issues

The Starworms (STop Anthelminthic Resistant WORMS) project aims to strengthen the monitoring and surveillance of drug efficacy and anthelmintic resistance in soil-transmitted helminth control programs. This Special Collection captures different aspects on how to best monitor the efficacy of current anthelmintic drugs and the emergence of anthelmintic resistance. Furthermore, we evaluate the global status of drug efficacy and anthelmintic resistance.

Image Credit: starworms.org

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PLOS Neglected Tropical Diseases

PLOS Neglected Tropical Diseases

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10.1371/journal.pntd.0011071 CC BY 4.0

PLOS Neglected Tropical Diseases A general framework to support cost-efficient fecal egg count methods and study design choices for large-scale STH deworming programs–monitoring of therapeutic drug efficacy as a case study
May 17, 2023 Luc E. Coffeng, Johnny Vlaminck, Piet Cools, Matthew Denwood, Marco Albonico, Shaali M. Ame, Mio Ayana, Daniel Dana, Giuseppe Cringoli, Sake J. de Vlas, Alan Fenwick, Michael French, Adama Kazienga, Jennifer Keiser, Stefanie Knopp, Gemechu Leta, Leonardo F. Matoso, Maria P. Maurelli, Antonio Montresor, Greg Mirams, Zeleke Mekonnen, Rodrigo Corrêa-Oliveira, Simone A. Pinto, Laura Rinaldi, Somphou Sayasone, Peter Steinmann, Eurion Thomas, Jozef Vercruysse, Bruno Levecke

Background: Soil-transmitted helminth (STH) control programs currently lack evidence-based recommendations for cost-efficient survey…
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10.1371/journal.pntd.0009888 CC BY 4.0

PLOS Neglected Tropical Diseases Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure
October 19, 2021 Martin Walker, Piet Cools, Marco Albonico, Shaali M. Ame, Mio Ayana, Daniel Dana, Jennifer Keiser, Leonardo F. Matoso, Antonio Montresor, Zeleke Mekonnen, Rodrigo Corrêa-Oliveira, Simone A, Pinto, Somphou Sayasone, Jozef Vercruysse, Johnny Vlaminck, Bruno Levecke

Background: Albendazole (ALB) is administered annually to millions of children through global deworming programs targeting soil-transmitted…
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10.1371/journal.pntd.0009777 CC BY 4.0

PLOS Neglected Tropical Diseases Characterization of the β-tubulin gene family in Ascaris lumbricoides and Ascaris suum and its implication for the molecular detection of benzimidazole resistance
September 27, 2021 Sara Roose, Russell W. Avramenko, Stephen M. J. Pollo, James D. Wasmuth, Shaali Ame, Mio Ayana, Martha Betson, Piet Cools, Daniel Dana, Ben P. Jones, Zeleke Mekonnen, Arianna Morosetti, Abhinaya Venkatesan, Johnny Vlaminck, Matthew L. Workentine, Bruno Levecke, John S. Gilleard, Peter Geldhof

Background: The treatment coverage of control programs providing benzimidazole (BZ) drugs to eliminate the morbidity caused by…
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10.1371/journal.pntd.0008625

PLOS Neglected Tropical Diseases An in-depth report of quality control on Kato-Katz and data entry in four clinical trials evaluating the efficacy of albendazole against soil-transmitted helminth infections
September 21, 2020 Johnny Vlaminck, Piet Cools, Marco Albonico, Shaali Ame, Mio Ayana, Daniel Dana, Jennifer Keiser, Leonardo F. Matoso, Antonio Montresor, Zeleke Mekonnen, Rodrigo Corrêa-Oliveira, Simone A. Pinto, Somphou Sayasone, Jozef Vercruysse, Bruno Levecke
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10.1371/journal.pntd.0008296

PLOS Neglected Tropical Diseases Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAK^G2, McMaster, Mini-FLOTAC and qPCR
July 2, 2020 Bruno Levecke, Piet Cools, Marco Albonico, Shaali Ame, Cécile Angebault, Mio Ayana, Jerzy M. Behnke, Jeffrey M. Bethony, Giuseppe Cringoli, Daniel Dana, Bertrand Guillard, Nguyen Thi Viet Hoa, Gagandeep Kang, Deepthi Kattula, Jennifer Keiser, Andrew C. Kotze, Leonardo F. Matoso, Maria P. Maurelli, James S. McCarthy, Zeleke Mekonnen, Greg Mirams, Antonio Montresor, Rodrigo Corrêa Oliveira, Maria V. Periago, Simone A. Pinto, Laura Rinaldi, Somphou Sayasone, Laurentine Sumo, Louis-Albert Tchuem-Tchuenté, Dang Thi Cam Thach, Eurion Thomas, Ahmed Zeynudin, Jaco J. Verweij, Johnny Vlaminck, Jozef Vercruysse
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10.1371/journal.pntd.0008231

PLOS Neglected Tropical Diseases First international external quality assessment scheme of nucleic acid amplification tests for the detection of Schistosoma and soil-transmitted helminths, including Strongyloides: A pilot study.
June 16, 2020 Piet Cools, Lisette van Lieshout, Rob Koelewijn, David Addiss, Sitara Ajjampur, Mio Ayana, Richard Bradbury, Jason Cantera, Daniel Dana, Kerstin Fischer, Rubina Imtiaz, Joyce Kabagenyi, James Lok, James McCarthy, Rojelio Mejia, Zeleke Mekonnen, Sammy Njenga, Nurulhasanah Othman, Hongguang Shao, Rebecca Traub, Marjan Van Esbroeck, Jozef Vercruysse, Johnny Vlaminck, Steven Williams, Jaco Verweij, Jaap van Hellemond, Bruno Levecke
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10.1371/journal.pntd.0007778

PLOS Neglected Tropical Diseases Comparison of four DNA extraction and three preservation protocols for the molecular detection and quantification of soil-transmitted helminths in stool
October 28, 2019 Mio Ayana, Piet Cools, Zeleke Mekonnen, Abdissa Biruksew, Daniel Dana, Nour Rashwan, Roger Prichard, Johnny Vlaminck, Jaco J. Verweij, Bruno Levecke
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10.1371/journal.pntd.0006912

PLOS Neglected Tropical Diseases Comprehensive evaluation of stool-based diagnostic methods and benzimidazole resistance markers to assess drug efficacy and detect the emergence of anthelmintic resistance: A Starworms study protocol
November 2, 2018 Johnny Vlaminck, Piet Cools, Marco Albonico, Shaali Ame, Mio Ayana, Jeffrey Bethony, Giuseppe Cringoli, Daniel Dana, Jennifer Keiser, Maria P. Maurelli, Antonio Montresor, Zeleke Mekonnen, Greg Mirams, Rodrigo Corrêa-Oliveira, Roger Prichard, Nour Rashwan, Laura Rinaldi, Somphou Sayasone, Eurion Thomas, Jaco J. Verweij, Jozef Vercruysse, Bruno Levecke
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10.1371/journal.pntd.0006655

PLOS Neglected Tropical Diseases Modification and optimization of the FECPAK^G2 protocol for the detection and quantification of soil-transmitted helminth eggs in human stool
October 15, 2018 Mio Ayana, Piet Cools, Shaali Ame, Marco Albonico, Daniel Dana, Jennifer Keiser, Helen Manly, Leonardo F. Matoso, Zeleke Mekonnen, Antonio Montresor, Rodrigo Correa-Oliveira, Laura Rinaldi, Somphou Sayasone, Stephen Sowersby, Lensa Tesfaye, Jozef Vercruysse, Greg Mirams, Bruno Levecke, Johnny Vlaminck
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10.1371/journal.pntd.0007471

PLOS Neglected Tropical Diseases Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods.
August 1, 2019 Johnny Vlaminck, Piet Cools, Marco Albonico, Shaali Ame, Mio Ayana, Guiseppe Cringoli, Daniel Dana, Jennifer Keiser, Maira Maurelli, Leonardo Matoso, Antonio Montresor, Zeleke Mekonnen, Greg Mirams, Rodrigo Correa-Oliveira, Simone Pinto, Laura Rinaldi, Somphou Sayasone, Eurion Thomas, Jozef Vercruysse, Jaco Verweij, Bruno Levecke
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10.1371/journal.pntd.0007446

PLOS Neglected Tropical Diseases Diagnostic performance of a single and duplicate Kato-Katz, Mini-FLOTAC, FECPAK^G2 and qPCR for the detection and quantification of soil-transmitted helminths in three endemic countries
August 1, 2019 Piet Cools, Johnny Vlaminck, Marco Albonico, Shaali Ame, Mio Ayana, Barrios Perez José Antonio, Guiseppe Cringoli, Daniel Dana, Jennifer Keiser, Maira Maurelli, Catalina Maya, Leonardo Matoso, Antonio Montresor, Zeleke Mekonnen, Greg Mirams, Rodrigo Corrêa-Oliveira, Simone Pinto, Laura Rinaldi, Somphou Sayasone, Eurion Thomas, Jaco Verweij, Jozef Vercruysse, Bruno Levecke

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