Medicine & Health

Investigating the Impact of Treatment on New HIV Infections

Published June 8, 2016 Partnered Collections, Special Issues

The HIV Modelling Consortium aims to strengthen the support that mathematical modelling and related quantitative disciplines can provide to global decision-making in HIV. In November 2011 the HIV Modelling Consortium held a meeting in South Africa to focus on the cross-cutting issues of the impact of new scientific findings about HIV treatment preventing new infections. The group considered the feasibility of interventions, potential epidemiological impact, affordability, and new scientific observational studies and community trials. The nine reviews and one research article which comprise this collection arose from that meeting and provide insights into the factors which will support evidence-based decision-making in HIV prevention, with a focus on the use of antiretroviral treatment to prevent HIV transmission.

Image Credit: Psyberartist at flickr.com, Manta Ray Media/HIV Modelling Consortium

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Reviews
Research Article

Reviews

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10.1371/journal.pmed.1001239

PLOS Medicine HIV Treatment as Prevention: Principles of Good HIV Epidemiology Modelling for Public Health Decision-Making in All Modes of Prevention and Evaluation
July 10, 2012 Wim Delva, David Wilson, Laith Abu-Raddad, Marelize Gorgens, David Wilson, Timothy Hallett, Alex Welte
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10.1371/journal.pmed.1001250

PLOS Medicine HIV Treatment as Prevention: Considerations in the Design, Conduct, and Analysis of Cluster Randomized Controlled Trials of Combination HIV Prevention
July 10, 2012 Marie-Claude Boily, Benoit Mâsse, Ramzi Alsallaq, Nancy Padian, Jeffrey Eaton, Juan Vesga, Timothy Hallett
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10.1371/journal.pmed.1001231

PLOS Medicine HIV Treatment as Prevention: Natural Experiments Highlight Limits of Antiretroviral Treatment as HIV Prevention
July 10, 2012 David Wilson
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10.1371/journal.pmed.1001260

PLOS Medicine HIV Treatment as Prevention: The Utility and Limitations of Ecological Observation
July 10, 2012 M Smith, Kimberly Powers, Kathryn Meussig, William Miller, Myron Cohen
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10.1371/journal.pmed.1001232

PLOS Medicine HIV Treatment as Prevention: Debate and Commentary—Will Early Infection Compromise Treatment-as-Prevention Strategies?
July 10, 2012 Myron Cohen, Christopher Dye, Christopher Fraser, William Miller, Kimberly Powers, Brian Williams
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10.1371/journal.pmed.1001258

PLOS Medicine HIV Treatment as Prevention: Optimising the Impact of Expanded HIV Treatment Programmes
July 10, 2012 Wim Delva, Jeffrey Eaton, Fei Meng, Christophe Fraser, Richard White, Peter Vickerman, Marie-Claude Boily, Timothy Hallett
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Psyberartist at flickr.com, Manta Ray Media/HIV Modelling Consortium

PLOS Medicine HIV Treatment as Prevention: Issues in Economic Evaluation
July 10, 2012 Till Bärnighausen, Joshua Salomon, Nalinee Sangrujee
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10.1371/journal.pmed.1001247

PLOS Medicine HIV Treatment as Prevention: Modelling the Cost of Antiretroviral Treatment—State of the Art and Future Directions
July 10, 2012 Gesine Meyer-Rath, Mead Over
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10.1371/journal.pmed.1001259

PLOS Medicine HIV Treatment as Prevention: Models, Data, and Questions—Towards Evidence-Based Decision-Making
July 10, 2012 Timothy Hallett, Till Bärnighausen, Stephen Becker, Eran Bendavid, Anna Bershteyn, John Blandford, Marie-Claude Boily, David Burns, Valentina Cambiano, Myron Cohen, Íde Cremin, Wim Delva, Christopher Dye, Jeffrey Eaton, Matthias Egger, Christophe Fraser, Noya Galai, Geoff Garnett, Peter Ghys, Laura Heaton, Charles Holmes, Jan Hontelez, Britta Jewell, Olivia Keiser, Daniel Klein, Viviane Lima, Elisa Long, Rob Lyerla, Christiaan Marais, Fei Meng, Gesine Meyer-Rath, William Miller, Nicholas Muraguri, Brooke Nichols, Karima Nigmatulina, Mead Over, Nancy Padian, Andrew Phillips, Carel Pretorius, Christine Rousseau, Joshua Salomon, Nalinee Sangrujee, David Serwadda, Frank Tanser, Juan Vesga, Peter Vickerman, Damian Walker, Rui Wang, Alex Welte, Richard White, Brian Williams, David Wilson, David Wilson, Basia Zaba

Research Article

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10.1371/journal.pmed.1001245

PLOS Medicine HIV Treatment as Prevention: Systematic Comparison of Mathematical Models of the Potential Impact of Antiretroviral Therapy on HIV Incidence in South Africa
July 10, 2012 Jeffrey Eaton, Leigh Johnson, Joshua Salomon, Till Bärnighausen, Eran Bendavid, Anna Bershteyn, David Bloom, Valentina Cambiano, Christophe Fraser, Jan Hontelez, Salal Humair, Daniel Klein, Elisa Long, Andrew Phillips, Carel Pretorius, John Stover, Edward Wenger, Brian Williams, Timothy Hallett

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Collection Support

The collection is produced with support from the HIV Modelling Consortium, which was funded by a grant from the Bill & Melinda Gates Foundation.