Biology & Life Sciences

WorldLeish-6

Published October 14, 2019 Partnered Collections, Special Issues

There are currently 350 million people in 98 countries at risk of developing leishmaniasis, the vector-borne parasitic disease caused by various species of trypanosomatid protozoa in the genus of Leishmania. The 6th World Congress on Leishmaniasis (WL6) will take place in Toledo, Spain from 16 to 20 May 2017, with some 1500 attendees expected to attend. To accompany this major event, the WL6 Scientific Community, in partnership with PLOS Collections, called for research papers to be submitted for consideration for the WorldLeish-6 Collection. From those papers accepted to the collection, DNDi will award prizes to 20 researchers at WL6. The WL6 Scientific Committee will decide which papers receive the prizes, which are intended to help fund the publication of future research in this field.

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WorldLeish6 Award Winners
WorldLeish-6
Understanding the Parasite
Developing New Tools for Treatment and Diagnosis
Clinical and Experimental Aspects of Disease and Treatment/Prevention
Epidemiology and Control
Public Health and Social Sciences
Funding

WorldLeish6 Award Winners

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10.1371/journal.pntd.0007765

PLOS Neglected Tropical Diseases Longitudinal evaluation of asymptomatic Leishmania infection in HIV-infected individuals in North-West Ethiopia: a pilot study
October 8, 2019 Johan van Griensven, Saskia van Henten, Bewketu Mengesha, Mekibib Kassa, Emebet Adem, Mengistu Endris Seid, Saïd Abdellati, Wondimu Asefa, Tesfa Simegn, Degnachew Debasu, Tadfe Bogale, Yonas Gedamu, Dorien Van Den Bossche, Wim Adriaensen, Gert Van der Auwera, Lieselotte Cnops, Florian Vogt, Ermias Diro
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10.1371/journal.pntd.0007667

PLOS Neglected Tropical Diseases Ecology and seasonality of sandflies and potential reservoirs of cutaneous leishmaniasis in Ochollo, a hotspot in southern Ethiopia
August 19, 2019 Myrthe Pareyn, Emma Van den Bosch, Nigatu Girma, Natalie van Houtte, Stefan Van Dongen, Gert Van der Auwera, Fekadu Massebo, Simon Shibru, Herwig Leirs
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10.1371/journal.pone.0215741

PLOS ONE Synanthropy and diversity of Phlebotominae in an area of intense transmission of visceral leishmaniasis in the South Pantanal floodplain, Midwest Brazil
May 14, 2019 Suellem Petilim Gomes Barrios, Luciana Escalante Pereira, Neiva Zandonaide Nazário Monaco, Gustavo Graciolli, Aline Etelvina Casaril, Jucelei de Oliveira Moura Infran, Everton Falcão de Oliveira, Wagner de Souza Fernandes, Antônio Conceição Paranhos Filho, Alessandra Gutierrez de Oliveira
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10.1371/journal.pone.0214413

PLOS ONE Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients
March 26, 2019 Aline Mireille da Cunha Fievez, Maria Luciana Silva-Freitas, Anastácio de Queiroz Sousa, Joanna R. Santos-Oliveira, Alda M. Da-Cruz
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10.1371/journal.pntd.0005459

PLOS Neglected Tropical Diseases Cost-effectiveness of meglumine antimoniate versus miltefosine caregiver DOT for the treatment of pediatric cutaneous leishmaniasis
April 6, 2017 Brandon A. Berger, Alexandra Cossio, Nancy Gore Saravia, Maria del Mar Castro, Sergio Prada, Allison H. Bartlett, Mai T. Pho
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10.1371/journal.pntd.0005401

PLOS Neglected Tropical Diseases Experimental infection and transmission of Leishmania by Lutzomyia cruzi (Diptera: Psychodidae): Aspects of the ecology of parasite-vector interactions
February 24, 2017 Everton Falcão de Oliveira, Elisa Teruya Oshiro, Wagner de Souza Fernandes, Paula Guerra Murat, Márcio José de Medeiros, Alda Izabel Souza, Alessandra Gutierrez de Oliveira, Eunice Aparecida Bianchi Galati
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10.1371/journal.pone.0155224

PLOS ONE Compartmentalized Immune Response in Leishmaniasis: Changing Patterns throughout the Disease
May 12, 2016 Alhelí Rodríguez-Cortés, Eugenia Carrillo, Susanna Martorell, Felicitat Todolí, Ana Ojeda, Alba Martínez-Flórez, Alicia Urniza, Javier Moreno, Jordi Alberola
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10.1371/journal.pone.0171306

PLOS ONE Apoptosis-like cell death in Leishmania donovani treated with KalsomeTM10, a new liposomal amphotericin B
February 7, 2017 Md. Shadab, Baijayanti Jha, Mohammad Asad, Makaraju Deepthi, Mohd. Kamran, Nahid Ali
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10.1371/journal.pone.0167512

PLOS ONE Immune Activation and Bacterial Translocation: A Link between Impaired Immune Recovery and Frequent Visceral Leishmaniasis Relapses in HIV-Infected Patients
December 1, 2016 Maria Luciana Silva-Freitas, Glaucia Fernandes Cota, Talia S. Machado-de-Assis, Carmem Giacoia-Gripp, Ana Rabello, Alda M. Da-Cruz, Joanna R. Santos-Oliveira
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10.1371/journal.pntd.0005420

PLOS Neglected Tropical Diseases Single locus genotyping to track Leishmania donovani in the Indian subcontinent: Application in Nepal
March 1, 2017 Keshav Rai, Narayan Raj Bhattarai, Manu Vanaerschot, Hideo Imamura, Gebreyohans Gebru, Basudha Khanal, Suman Rijal, Marleen Boelaert, Chiranjib Pal, Prahlad Karki, Jean-Claude Dujardin, Gert Van der Auwera
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10.1371/journal.pntd.0005240

PLOS Neglected Tropical Diseases Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid
January 18, 2017 Patrik Castiglioni, Mary-Anne Hartley, Matteo Rossi, Florence Prevel, Chantal Desponds, Daniel T. Utzschneider, Remzi-Onur Eren, Haroun Zangger, Livia Brunner, Nicolas Collin, Dietmar Zehn, F. Matthew Kuhlmann, Stephen M. Beverley, Catherine Ronet, Nicolas Fasel
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10.1371/journal.ppat.1005852

PLOS Pathogens Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A
September 22, 2016 Mary-Anne Hartley, Eliane Bourreau, Matteo Rossi, Patrik Castiglioni, Remzi Onur Eren, Florence Prevel, Pierre Couppié, Suzanne M. Hickerson, Pascal Launois, Stephen M. Beverley, Catherine Ronet, Nicolas Fasel
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10.1371/journal.ppat.1006130

PLOS Pathogens Leishmania HASP and SHERP Genes Are Required for In Vivo Differentiation, Parasite Transmission and Virulence Attenuation in the Host
January 17, 2017 Johannes S. P. Doehl, Jovana Sádlová, Hamide Aslan, Kateřina Pružinová, Sonia Metangmo, Jan Votýpka, Shaden Kamhawi, Petr Volf, Deborah F. Smith
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10.1371/journal.ppat.1006165

PLOS Pathogens Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype
January 31, 2017 Fanping Kong, Omar A. Saldarriaga, Heidi Spratt, E. Yaneth Osorio, Bruno L. Travi, Bruce A. Luxon, Peter C. Melby

WorldLeish-6

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WorldLeish

PLOS Collections Blog Update to PLOS WorldLeish-6 Collection
January 12, 2017 PLOS Collections
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WorldLeish-6

PLOS Collections Blog The PLOS WorldLeish-6 Collection – call for additional papers
December 2, 2016 Jorge Alvar, Javier Moreno
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CDC / Public Domain

PLOS Collections Blog UPDATE – Leishmaniasis: Call for papers for PLOS WorldLeish-6 Collection
May 16, 2016 Jorge Alvar, Javier Moreno

Understanding the Parasite

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10.1371/journal.pntd.0005782

PLOS Neglected Tropical Diseases A putative ATP/GTP binding protein affects Leishmania mexicana growth in insect vectors and vertebrate hosts
July 24, 2017 Aygul Ishemgulova, Natalya Kraeva, Jana Hlaváčová, Sara L. Zimmer, Anzhelika Butenko, Lucie Podešvová, Tereza Leštinová, Julius Lukeš, Alexei Kostygov, Jan Votýpka, Petr Volf, Vyacheslav Yurchenko
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10.1371/journal.pone.0177372

PLOS ONE HAT2 mediates histone H4K4 acetylation and affects micrococcal nuclease sensitivity of chromatin in Leishmania donovani
May 9, 2017 Pravin K. Jha, Mohd. Imran Khan, Anshul Mishra, Pradeep Das, Kislay K. Sinha
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10.1371/journal.pone.0178201

PLOS ONE A Leishmania secretion system for the expression of major ampullate spidroin mimics
May 23, 2017 Todd A. Lyda, Elizabeth L. Wagner, Andre X. Bourg, Congyue Peng, Golnaz Najaf Tomaraei, Delphine Dean, Marian S. Kennedy, William R. Marcotte Jr.
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10.1371/journal.ppat.1006459

PLOS Pathogens Leishmania donovani resides in modified early endosomes by upregulating Rab5a expression via the downregulation of miR-494
June 26, 2017 Jitender Kumar Verma, Ruchir Rastogi, Amitabha Mukhopadhyay
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10.1371/journal.pone.0178800

PLOS ONE Intracellular zinc flux causes reactive oxygen species mediated mitochondrial dysfunction leading to cell death in Leishmania donovani
June 6, 2017 Anjali Kumari, Krishn Pratap Singh, Abhishek Mandal, Ranjeet Kumar Paswan, Preeti Sinha, Pradeep Das, Vahab Ali, Sanjiva Bimal, Chandra Shekhar Lal
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10.1371/journal.pntd.0005649

PLOS Neglected Tropical Diseases Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana
June 16, 2017 Roy Mwenechanya, Julie Kovářová, Nicholas J. Dickens, Manikhandan Mudaliar, Pawel Herzyk, Isabel M. Vincent, Stefan K. Weidt, Karl E. Burgess, Richard J. S. Burchmore, Andrew W. Pountain, Terry K. Smith, Darren J. Creek, Dong-Hyun Kim, Galina I. Lepesheva, Michael P. Barrett
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10.1371/journal.pntd.0005641

PLOS Neglected Tropical Diseases Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stress
June 2, 2017 Deepak Kumar Deep, Ruchi Singh, Vasundhra Bhandari, Aditya Verma, Vanila Sharma, Saima Wajid, Shyam Sundar, V. Ramesh, Jean Claude Dujardin, Poonam Salotra
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10.1371/journal.pntd.0005590

PLOS Neglected Tropical Diseases The mitochondrial SIR2 related protein 2 (SIR2RP2) impacts Leishmania donovani growth and infectivity
May 11, 2017 Nimisha Mittal, Rohini Muthuswami, Rentala Madhubala
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Fox-Lewis A, Lockwood DNJ, 2017

PLOS Neglected Tropical Diseases Visceral leishmaniasis complicating idiopathic CD4⁺ T-cell lymphocytopenia: 2 case reports
May 11, 2017 Andrew Fox-Lewis, Diana N. J. Lockwood
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10.1371/journal.pone.0174024

PLOS ONE Insight into the mechanism of action of temporin-SHa, a new broad-spectrum antiparasitic and antibacterial agent
March 20, 2017 Zahid Raja, Sonia André, Feten Abbassi, Vincent Humblot, Olivier Lequin, Tahar Bouceba, Isabelle Correia, Sandra Casale, Thierry Foulon, Denis Sereno, Bruno Oury, Ali Ladram
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10.1371/journal.pntd.0005413

PLOS Neglected Tropical Diseases Cytokines and microbicidal molecules regulated by IL-32 in THP-1-derived human macrophages infected with New World Leishmania species
February 27, 2017 Jéssica Cristina dos Santos, Bas Heinhuis, Rodrigo Saar Gomes, Michelle S. M. A. Damen, Fernando Real, Renato A. Mortara, Samuel T. Keating, Charles A. Dinarello, Leo A. B. Joosten, Fátima Ribeiro-Dias
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10.1371/journal.pone.0171850

PLOS ONE Enhanced survival of Leishmania major in neutrophil granulocytes in the presence of apoptotic cells
February 10, 2017 Natallia Salei, Lars Hellberg, Jörg Köhl, Tamás Laskay
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10.1371/journal.ppat.1006165

PLOS Pathogens Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype
January 31, 2017 Fanping Kong, Omar A. Saldarriaga, Heidi Spratt, E. Yaneth Osorio, Bruno L. Travi, Bruce A. Luxon, Peter C. Melby
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10.1371/journal.pone.0170068

PLOS ONE Comprehensive Identification of mRNA-Binding Proteins of Leishmania donovani by Interactome Capture
January 30, 2017 Devki Nandan, Sneha A. Thomas, Anne Nguyen, Kyung-Mee Moon, Leonard J. Foster, Neil E. Reiner
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10.1371/journal.pone.0169496

PLOS ONE Splenic CD4⁺ T Cells in Progressive Visceral Leishmaniasis Show a Mixed Effector-Regulatory Phenotype and Impair Macrophage Effector Function through Inhibitory Receptor Expression
January 19, 2017 Audrie A. Medina-Colorado, Elvia Y. Osorio, Omar A. Saldarriaga, Bruno L. Travi, Fanping Kong, Heidi Spratt, Lynn Soong, Peter C. Melby
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10.1371/journal.pntd.0005240

PLOS Neglected Tropical Diseases Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid
January 18, 2017 Patrik Castiglioni, Mary-Anne Hartley, Matteo Rossi, Florence Prevel, Chantal Desponds, Daniel T. Utzschneider, Remzi-Onur Eren, Haroun Zangger, Livia Brunner, Nicolas Collin, Dietmar Zehn, F. Matthew Kuhlmann, Stephen M. Beverley, Catherine Ronet, Nicolas Fasel
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10.1371/journal.ppat.1006130

PLOS Pathogens Leishmania HASP and SHERP Genes Are Required for In Vivo Differentiation, Parasite Transmission and Virulence Attenuation in the Host
January 17, 2017 Johannes S. P. Doehl, Jovana Sádlová, Hamide Aslan, Kateřina Pružinová, Sonia Metangmo, Jan Votýpka, Shaden Kamhawi, Petr Volf, Deborah F. Smith
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10.1371/journal.pone.0168339

PLOS ONE Leishmania infantum Induces Mild Unfolded Protein Response in Infected Macrophages
December 15, 2016 Luca Galluzzi, Aurora Diotallevi, Mauro De Santi, Marcello Ceccarelli, Fabrizio Vitale, Giorgio Brandi, Mauro Magnani
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10.1371/journal.ppat.1005962

PLOS Pathogens Exploitation of the Host Cell Membrane Fusion Machinery by Leishmania Is Part of the Infection Process
December 8, 2016 Christine Matte, Albert Descoteaux
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10.1371/journal.pntd.0005171

PLOS Neglected Tropical Diseases Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms
December 2, 2016 Christopher Fernandez-Prada, Isabel M. Vincent, Marie-Christine Brotherton, Mathew Roberts, Gaétan Roy, Luis Rivas, Philippe Leprohon, Terry K. Smith, Marc Ouellette
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10.1371/journal.pntd.0004992

PLOS Neglected Tropical Diseases Meta-transcriptome Profiling of the Human-Leishmania braziliensis Cutaneous Lesion
September 15, 2016 Stephen M. Christensen, Laura A. L. Dillon, Lucas P. Carvalho, Sara Passos, Fernanda O. Novais, V. Keith Hughitt, Daniel P. Beiting, Edgar M. Carvalho, Phillip Scott, Najib M. El-Sayed, David M. Mosser
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10.1371/journal.ppat.1005852

PLOS Pathogens Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A
September 22, 2016 Mary-Anne Hartley, Eliane Bourreau, Matteo Rossi, Patrik Castiglioni, Remzi Onur Eren, Florence Prevel, Pierre Couppié, Suzanne M. Hickerson, Pascal Launois, Stephen M. Beverley, Catherine Ronet, Nicolas Fasel
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10.1371/journal.ppat.1005690

PLOS Pathogens Leishmania major Promastigotes Evade LC3-Associated Phagocytosis through the Action of GP63
June 9, 2016 Christine Matte, Pierre-André Casgrain, Olivier Séguin, Neda Moradin, Wan Jin Hong, Albert Descoteaux
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10.1371/journal.ppat.1005658

PLOS Pathogens Cysteine Peptidase B Regulates Leishmania mexicana Virulence through the Modulation of GP63 Expression
May 18, 2016 Pierre-André Casgrain, Caroline Martel, W. Robert McMaster, Jeremy C. Mottram, Martin Olivier, Albert Descoteaux

Developing New Tools for Treatment and Diagnosis

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10.1371/journal.pntd.0005480

PLOS Neglected Tropical Diseases The enemy within: Targeting host–parasite interaction for antileishmanial drug discovery
June 8, 2017 Suzanne Lamotte, Gerald F. Späth, Najma Rachidi, Eric Prina
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10.1371/journal.pntd.0005556

PLOS Neglected Tropical Diseases Structurally optimized analogs of the retrograde trafficking inhibitor Retro-2cycl limit Leishmania infections
May 15, 2017 Evan Craig, Charles-Eugene Huyghues-Despointes, Chun Yu, Emma L. Handy, Jason K. Sello, Peter E. Kima
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10.1371/journal.pntd.0005629

PLOS Neglected Tropical Diseases Unravelling the rate of action of hits in the Leishmania donovani box using standard drugs amphotericin B and miltefosine
May 25, 2017 Diana Tegazzini, Juan Cantizani, Imanol Peña, Julio Martín, Jose M. Coterón
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10.1371/journal.pntd.0005562

PLOS Neglected Tropical Diseases Epitope mapping of recombinant Leishmania donovani virulence factor A2 (recLdVFA2) and canine leishmaniasis diagnosis using a derived synthetic bi-epitope
May 30, 2017 Thais Melo Mendes, Eric Henrique Roma, Fernanda Costal-Oliveira, Lucas de Carvalho Dhom-Lemos, Cristina Monerat Toledo-Machado, Oscar Bruna-Romero, Daniella Castanheiras Bartholomeu, Ricardo Toshio Fujiwara, Carlos Chávez-Olórtegui
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10.1371/journal.pntd.0005486

PLOS Neglected Tropical Diseases sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis
March 29, 2017 Ricardo Luís Louzada Silva, Marcio B. Santos, Priscila L. S. Almeida, Thayse S. Barros, Lucas Magalhães, Rodrigo A. Cazzaniga, Patrícia R. M. Souza, Nívea F. Luz, Jaqueline França-Costa, Valeria M. Borges, Djalma S. Lima-Junior, Michael W. Lipscomb, Malcolm S. Duthie, Steven G. Reed, Roque Pacheco Almeida, Amélia Ribeiro Jesus
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10.1371/journal.pone.0173922

PLOS ONE Multiplex PCR as a tool for the diagnosis of Leishmania spp. kDNA and the gapdh housekeeping gene of mammal hosts
March 16, 2017 Renata de Cássia-Pires, Myllena de Fátima Alheiros Dias de Melo, Raquel da Hora Barbosa, André Luiz Rodrigues Roque
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10.1371/journal.pntd.0005420

PLOS Neglected Tropical Diseases Single locus genotyping to track Leishmania donovani in the Indian subcontinent: Application in Nepal
March 1, 2017 Keshav Rai, Narayan Raj Bhattarai, Manu Vanaerschot, Hideo Imamura, Gebreyohans Gebru, Basudha Khanal, Suman Rijal, Marleen Boelaert, Chiranjib Pal, Prahlad Karki, Jean-Claude Dujardin, Gert Van der Auwera
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10.1371/journal.pntd.0005311

PLOS Neglected Tropical Diseases Identification of BALB/c Immune Markers Correlated with a Partial Protection to Leishmania infantum after Vaccination with a Rationally Designed Multi-epitope Cysteine Protease A Peptide-Based Nanovaccine
January 23, 2017 Maria Agallou, Maritsa Margaroni, Evita Athanasiou, Dimitra K. Toubanaki, Katerina Kontonikola, Konstantina Karidi, Olga Kammona, Costas Kiparissides, Evdokia Karagouni
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Kimutai et al

Clinical Drug Investigation Safety and Effectiveness of Sodium Stibogluconate and Paromomycin Combination for the Treatment of Visceral Leishmaniasis in Eastern Africa: Results from a Pharmacovigilance Programme
January 9, 2017 Robert Kimutai, Ahmed M. Musa, Simon Njoroge, Raymond Omollo, Fabiana Alves, Asrat Hailu, Eltahir A. G. Khalil, Ermias Diro, Peninah Soipei, Brima Musa, Khalid Salman, Koert Ritmeijer, Francois Chappuis, Juma Rashid, Rezika Mohammed, Asfaw Jameneh, Eyasu Makonnen, Joseph Olobo, Lawrence Okello, Patrick Sagaki, Nathalie Strub, Sally Ellis, Jorge Alvar, Manica Balasegaram, Emilie Alirol, Monique Wasunna

Clinical and Experimental Aspects of Disease and Treatment/Prevention

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Fox-Lewis A, Lockwood DNJ, 2017

PLOS Neglected Tropical Diseases Visceral leishmaniasis complicating idiopathic CD4⁺ T-cell lymphocytopenia: 2 case reports
May 11, 2017 Andrew Fox-Lewis, Diana N. J. Lockwood
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10.1371/journal.pone.0180530

PLOS ONE In vitro additive interaction between ketoconazole and antimony against intramacrophage Leishmania (Leishmania) amazonensis amastigotes
June 29, 2017 Débora Cristina de Oliveira Nunes, Luiz Borges Bispo-da-Silva, Danielle Reis Napolitano, Mônica Soares Costa, Márcia Moura Nunes Rocha Figueira, Renata Santos Rodrigues, Veridiana de Melo Rodrigues, Kelly Aparecida Geraldo Yoneyama
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10.1371/journal.ppat.1006479

PLOS Pathogens Divergent roles for Ly6C⁺CCR2⁺CX3CR1⁺ inflammatory monocytes during primary or secondary infection of the skin with the intra-phagosomal pathogen Leishmania major
June 30, 2017 Audrey Romano, Matheus B. H. Carneiro, Nicole A. Doria, Eric H. Roma, Flavia L. Ribeiro-Gomes, Ehud Inbar, Sang Hun Lee, Jonatan Mendez, Andrea Paun, David L. Sacks, Nathan C. Peters
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10.1371/journal.ppat.1006465

PLOS Pathogens TNF signalling drives expansion of bone marrow CD4⁺ T cells responsible for HSC exhaustion in experimental visceral leishmaniasis
July 3, 2017 Ana Isabel Pinto, Najmeeyah Brown, Olivier Preham, Johannes S. P. Doehl, Helen Ashwin, Paul M. Kaye
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10.1371/journal.pone.0178592

PLOS ONE Low versus high dose of antimony for American cutaneous leishmaniasis: A randomized controlled blind non-inferiority trial in Rio de Janeiro, Brazil
May 30, 2017 Mauricio Naoto Saheki, Marcelo Rosandiski Lyra, Sandro Javier Bedoya-Pacheco, Liliane de Fátima Antônio, Maria Inês Fernandes Pimentel, Mariza de Matos Salgueiro, Érica de Camargo Ferreira e Vasconcellos, Sonia Regina Lambert Passos, Ginelza Peres Lima dos Santos, Madelon Novato Ribeiro, Aline Fagundes, Maria de Fátima Madeira, Eliame Mouta-Confort, Mauro Célio de Almeida Marzochi, Cláudia Maria Valete-Rosalino, Armando de Oliveira Schubach
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10.1371/journal.pntd.0005527

PLOS Neglected Tropical Diseases A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH
May 12, 2017 Mohamed Osman, Anoop Mistry, Ada Keding, Rhian Gabe, Elizabeth Cook, Sarah Forrester, Rebecca Wiggins, Stefania Di Marco, Stefano Colloca, Loredana Siani, Riccardo Cortese, Deborah F. Smith, Toni Aebischer, Paul M. Kaye, Charles J. Lacey
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10.1371/journal.pntd.0005706

PLOS Neglected Tropical Diseases Efficacy and safety of available treatments for visceral leishmaniasis in Brazil: A multicenter, randomized, open label trial
June 29, 2017 Gustavo Adolfo Sierra Romero, Dorcas Lamounier Costa, Carlos Henrique Nery Costa, Roque Pacheco de Almeida, Enaldo Viera de Melo, Sílvio Fernando Guimarães de Carvalho, Ana Rabello, Andréa Lucchesi de Carvalho, Anastácio de Queiroz Sousa, Robério Dias Leite, Simone Soares Lima, Thais Alves Amaral, Fabiana Piovesan Alves, Joelle Rode, the Collaborative LVBrasil Group
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10.1371/journal.pntd.0005635

PLOS Neglected Tropical Diseases Safety and efficacy of short course combination regimens with AmBisome, miltefosine and paromomycin for the treatment of visceral leishmaniasis (VL) in Bangladesh
May 30, 2017 Ridwanur Rahman, Rashidul Haque, Kazi Jamil, Abul Faiz, Rasheda Samad, Sally Ellis, Manica Balasegaram, Margriet den Boer, Suman Rijal, Nathalie Strub-Wourgaft, Fabiana Alves, Jorge Alvar, Bhawna Sharma, Vishal Goyal
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10.1371/journal.pntd.0005644

PLOS Neglected Tropical Diseases Vaccination with a Leishmania infantum HSP70-II null mutant confers long-term protective immunity against Leishmania major infection in two mice models
May 30, 2017 José Carlos Solana, Laura Ramírez, Laura Corvo, Camila Indiani de Oliveira, Manoel Barral-Netto, José María Requena, Salvador Iborra, Manuel Soto
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10.1371/journal.pntd.0005620

PLOS Neglected Tropical Diseases Combined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum
May 15, 2017 Sarah Hendrickx, Magali Van den Kerkhof, Dorien Mabille, Paul Cos, Peter Delputte, Louis Maes, Guy Caljon
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10.1371/journal.pntd.0005515

PLOS Neglected Tropical Diseases Risk factors for therapeutic failure to meglumine antimoniate and miltefosine in adults and children with cutaneous leishmaniasis in Colombia: A cohort study
April 5, 2017 Maria del Mar Castro, Alexandra Cossio, Carlos Velasco, Lyda Osorio
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10.1371/journal.pone.0174497

PLOS ONE To evaluate efficacy and safety of amphotericin B in two different doses in the treatment of post kala-azar dermal leishmaniasis (PKDL)
March 29, 2017 Vidya Nand Rabi Das, Niyamat Ali Siddiqui, Biplab Pal, Chandra Shekhar Lal, Neena Verma, Ashish Kumar, Rakesh Bihari Verma, Dhirendra Kumar, Pradeep Das, Krishna Pandey
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10.1371/journal.pntd.0005374

PLOS Neglected Tropical Diseases Structure of SALO, a leishmaniasis vaccine candidate from the sand fly Lutzomyia longipalpis
March 9, 2017 Oluwatoyin A. Asojo, Alan Kelleher, Zhuyun Liu, Jeroen Pollet, Elissa M. Hudspeth, Wanderson C. Rezende, Mallory Jo Groen, Christopher A. Seid, Maha Abdeladhim, Shannon Townsend, Waldione de Castro, Antonio Mendes-Sousa, Daniella Castanheira Bartholomeu, Ricardo Toshio Fujiwara, Maria Elena Bottazzi, Peter J. Hotez, Bin Zhan, Fabiano Oliveira, Shaden Kamhawi, Jesus G. Valenzuela
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10.1371/journal.pone.0172525

PLOS ONE Safety evaluation of a vaccine: Effect in maternal reproductive outcome and fetal anomaly frequency in rats using a leishmanial vaccine as a model
March 1, 2017 Rafaianne Q. Moraes-Souza, Ana Paula Reinaque, Thaigra S. Soares, Ana Luiza T. Silva, Rodolfo C. Giunchetti, Maria A. S. Takano, Milena A. Akamatsu, Flávia S. Kubrusly, Fernanda Lúcio-Macarini, Isaias Raw, Dmitri Iourtov, Paulo Lee Ho, Lilian L. Bueno, Ricardo T. Fujiwara, Gustavo T. Volpato
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10.1371/journal.pntd.0005134

PLOS Neglected Tropical Diseases Visceral leishmaniasis during pregnancy: A rare case report from Greece
February 16, 2017 Periklis Panagopoulos, Antonios Papadopoulos, Spyridoula Theodorou, Chrysoula Christodoulaki, Kyriakos Aloupogiannis, Nikolaos Papantoniou, Vasileios Mitsopoulos
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10.1371/journal.pone.0171306

PLOS ONE Apoptosis-like cell death in Leishmania donovani treated with KalsomeTM10, a new liposomal amphotericin B
February 7, 2017 Md. Shadab, Baijayanti Jha, Mohammad Asad, Makaraju Deepthi, Mohd. Kamran, Nahid Ali
Image credit
10.1371/journal.ppat.1006165

PLOS Pathogens Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype
January 31, 2017 Fanping Kong, Omar A. Saldarriaga, Heidi Spratt, E. Yaneth Osorio, Bruno L. Travi, Bruce A. Luxon, Peter C. Melby
Image credit
10.1371/journal.pone.0168492

PLOS ONE Alterations in Evoked Otoacoustic Emissions by the Use of Meglumine Antimoniate in American Tegumentary Leishmaniasis Patients
January 3, 2017 Débora Cristina de Oliveira Bezerra, Renata Oliveira de Barcelos, Ellen Carvalho de Castro, Claudia Cristina Jardim Duarte, Raquel de Vasconcellos Carvalhaes Oliveira, Tania Salgado de Sousa Torraca, Maria Helena de Araújo-Melo, Frederico Pereira Bom Braga, Benivaldo Ramos Ferreira Terceiro, Lúcia Regina do Nascimento Brahim Paes, Armando de Oliveira Schubach, Cláudia Maria Valete-Rosalino
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10.1371/journal.pntd.0005281

PLOS Neglected Tropical Diseases Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice
January 3, 2017 Edézio Ferreira Cunha-Júnior, Valter Viana Andrade-Neto, Marta Lopes Lima, Thais Alves da Costa-Silva, Andres J. Galisteo Junior, Maria A. Abengózar, Coral Barbas, Luis Rivas, Elmo Eduardo Almeida-Amaral, Andre Gustavo Tempone, Eduardo Caio Torres-Santos
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10.1371/journal.pntd.0005234

PLOS Neglected Tropical Diseases Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions
December 30, 2016 Géraldine De Muylder, Benoit Vanhollebeke, Guy Caljon, Alan R. Wolfe, James McKerrow, Jean-Claude Dujardin
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10.1371/journal.pntd.0005100

PLOS Neglected Tropical Diseases Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects
December 1, 2016 Luiz Henrique Guimarães, Adriano Queiroz, Juliana A. Silva, Silvana C. Silva, Viviane Magalhães, Ednaldo L. Lago, Paulo Roberto L. Machado, Olívia Bacellar, Mary E. Wilson, Stephen M. Beverley, Edgar M. Carvalho, Albert Schriefer
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10.1371/journal.pone.0167512

PLOS ONE Immune Activation and Bacterial Translocation: A Link between Impaired Immune Recovery and Frequent Visceral Leishmaniasis Relapses in HIV-Infected Patients
December 1, 2016 Maria Luciana Silva-Freitas, Glaucia Fernandes Cota, Talia S. Machado-de-Assis, Carmem Giacoia-Gripp, Ana Rabello, Alda M. Da-Cruz, Joanna R. Santos-Oliveira
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10.1371/journal.pone.0163219

PLOS ONE The Challenge of Stability in High-Throughput Gene Expression Analysis: Comprehensive Selection and Evaluation of Reference Genes for BALB/c Mice Spleen Samples in the Leishmania infantum Infection Model
September 26, 2016 Yasmina E. Hernandez-Santana, Eduardo Ontoria, Ana C. Gonzalez-García, M. Antonieta Quispe-Ricalde, Vicente Larraga, Basilio Valladares, Emma Carmelo

Epidemiology and Control

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10.1371/journal.ppat.1006303

PLOS Pathogens Leishmania enriettii (Muniz & Medina, 1948): A highly diverse parasite is here to stay
May 25, 2017 Larissa F. Paranaiba, Lucélia J. Pinheiro, Ana C. Torrecilhas, Diego H. Macedo, Armando Menezes-Neto, Wagner L. Tafuri, Rodrigo P. Soares
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10.1371/journal.pone.0179118

PLOS ONE The current status of phlebotomine sand flies in Albania and incrimination of Phlebotomus neglectus (Diptera, Psychodidae) as the main vector of Leishmania infantum
June 19, 2017 Enkelejda Velo, Gioia Bongiorno, Perparim Kadriaj, Teita Myrseli, James Crilly, Aldin Lika, Kujtim Mersini, Trentina Di Muccio, Silvia Bino, Marina Gramiccia, Luigi Gradoni, Michele Maroli
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10.1371/journal.pone.0178996

PLOS ONE Development and external validation of a clinical prognostic score for death in visceral leishmaniasis patients in a high HIV co-infection burden area in Ethiopia
June 5, 2017 Charles Abongomera, Koert Ritmeijer, Florian Vogt, Jozefien Buyze, Zelalem Mekonnen, Henok Admassu, Robert Colebunders, Rezika Mohammed, Lutgarde Lynen, Ermias Diro, Johan van Griensven
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10.1371/journal.pone.0178628

PLOS ONE Aspects of the ecology of phlebotomine sand flies (Diptera: Psychodidae) in the Private Natural Heritage Reserve Sanctuary Caraça
June 1, 2017 Gabriel Barbosa Tonelli, Aline Tanure, Felipe Dutra Rêgo, Gustavo Mayr de Lima Carvalho, Taynãna César Simões, José Dilermando Andrade Filho
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10.1371/journal.pntd.0005538

PLOS Neglected Tropical Diseases Epidemiological analysis of Leishmania tropica strains and giemsa-stained smears from Syrian and Turkish leishmaniasis patients using multilocus microsatellite typing (MLMT)
April 12, 2017 Mehmet Karakuş, Abed Nasereddin, Hüseyin Onay, Emin Karaca, Ahmet Özkeklikçi, Charles L. Jaffe, Katrin Kuhls, Ahmet Özbilgin, Hatice Ertabaklar, Samiye Demir, Yusuf Özbel, Seray Töz
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10.1371/journal.pone.0175308

PLOS ONE Studies on sand fly fauna and ecological analysis of Phlebotomus orientalis in the highland and lowland foci of kala-azar in northwestern Ethiopia
April 6, 2017 Esayas Aklilu, Araya Gebresilassie, Solomon Yared, Mizan Kindu, Habte Tekie, Meshesha Balkew, Alon Warburg, Asrat Hailu, Teshome Gebre-Michael
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10.1371/journal.pntd.0005231

PLOS Neglected Tropical Diseases Visceral leishmaniasis in Somalia: A review of epidemiology and access to care
March 9, 2017 Temmy Sunyoto, Julien Potet, Marleen Boelaert
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10.1371/journal.pntd.0005406

PLOS Neglected Tropical Diseases Sand fly population dynamics and cutaneous leishmaniasis among soldiers in an Atlantic forest remnant in northeastern Brazil
February 27, 2017 Filipe Dantas-Torres, Kamila Gaudêncio da Silva Sales, Débora Elienai de Oliveira Miranda, Fernando José da Silva, Luciana Aguiar Figueredo, Fábio Lopes de Melo, Maria Edileuza Felinto de Brito, Maria Sandra Andrade, Sinval Pinto Brandão-Filho
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10.1371/journal.pntd.0005401

PLOS Neglected Tropical Diseases Experimental infection and transmission of Leishmania by Lutzomyia cruzi (Diptera: Psychodidae): Aspects of the ecology of parasite-vector interactions
February 24, 2017 Everton Falcão de Oliveira, Elisa Teruya Oshiro, Wagner de Souza Fernandes, Paula Guerra Murat, Márcio José de Medeiros, Alda Izabel Souza, Alessandra Gutierrez de Oliveira, Eunice Aparecida Bianchi Galati
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10.1371/journal.pntd.0005391

PLOS Neglected Tropical Diseases Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India
February 10, 2017 Pabitra Saha, Swagata Ganguly, Moytrey Chatterjee, Soumendu Bikash Das, Pratip K. Kundu, Subhasish K. Guha, Tamal K. Ghosh, Dilip K. Bera, Nandita Basu, Ardhendu K. Maji
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10.1371/journal.pntd.0005353

PLOS Neglected Tropical Diseases Risk analysis and prediction of visceral leishmaniasis dispersion in São Paulo State, Brazil
February 6, 2017 Anaiá da Paixão Sevá, Liang Mao, Fredy Galvis-Ovallos, Joanna Marie Tucker Lima, Denis Valle
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10.1371/journal.pntd.0005196

PLOS Neglected Tropical Diseases Longitudinal Study of Transmission in Households with Visceral Leishmaniasis, Asymptomatic Infections and PKDL in Highly Endemic Villages in Bihar, India
December 14, 2016 Vidya Nand Ravi Das, Ravindra Nath Pandey, Niyamat Ali Siddiqui, Lloyd A C Chapman, Vijay Kumar, Krishna Pandey, Pradeep Das, Greg Matlashewski
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10.1371/journal.pntd.0005150

PLOS Neglected Tropical Diseases Epidemiologic Correlates of Mortality among Symptomatic Visceral Leishmaniasis Cases: Findings from Situation Assessment in High Endemic Foci in India
November 21, 2016 Aritra Das, Morchan Karthick, Shweta Dwivedi, Indranath Banerjee, Sridhar Srikantiah, Indrajit Chaudhuri, Tanmay Mahapatra
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10.1371/journal.pone.0166191

PLOS ONE The Diversity of Yellow-Related Proteins in Sand Flies (Diptera: Psychodidae)
November 3, 2016 Michal Sima, Marian Novotny, Lukas Pravda, Petra Sumova, Iva Rohousova, Petr Volf
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10.1371/journal.pntd.0004896

PLOS Neglected Tropical Diseases Transmission Dynamics of Visceral Leishmaniasis in the Indian Subcontinent – A Systematic Literature Review
August 4, 2016 Siddhivinayak Hirve, Marleen Boelaert, Greg Matlashewski, Dinesh Mondal, Byron Arana, Axel Kroeger, Piero Olliaro
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10.1371/journal.pone.0160058

PLOS ONE Canine-Based Strategies for Prevention and Control of Visceral Leishmaniasis in Brazil
July 29, 2016 Anaiá P. Sevá, Fredy G. Ovallos, Marcus Amaku, Eugenia Carrillo, Javier Moreno, Eunice A. B. Galati, Estela G. Lopes, Rodrigo M. Soares, Fernando Ferreira
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10.1371/journal.pone.0155224

PLOS ONE Compartmentalized Immune Response in Leishmaniasis: Changing Patterns throughout the Disease
May 12, 2016 Alhelí Rodríguez-Cortés, Eugenia Carrillo, Susanna Martorell, Felicitat Todolí, Ana Ojeda, Alba Martínez-Flórez, Alicia Urniza, Javier Moreno, Jordi Alberola
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10.1371/journal.pntd.0004553

PLOS Neglected Tropical Diseases Recombinant Salivary Proteins of Phlebotomus orientalis are Suitable Antigens to Measure Exposure of Domestic Animals to Sand Fly Bites
March 17, 2016 Michal Sima, Blanka Ferencova, Alon Warburg, Iva Rohousova, Petr Volf

Funding

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CDC/Dr. L.L. Moore, Jr., Wikipedia

PLOS Neglected Tropical Diseases Investments in Research and Surveillance Are Needed to Go Beyond Elimination and Stop Transmission of Leishmania in the Indian Subcontinent
January 26, 2017 Piero L. Olliaro, Tushar A. K. M. Shamsuzzaman, Baburam Marasini, A. C. Dhariwal, Ahmed Be-Nazir, Dinesh Mondal, Megha Raj Banjara, Pradeep Das, Shyam Sundar, Suman Rijal, Byron Arana, Jorge Alvar, Daniel Argaw, Rosanna W. Peeling, Axel Kroeger, Greg Matlashewski